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Article: Iron depletion decreases proliferation and induces apoptosis in a human colonic adenocarcinoma cell line, Caco2

TitleIron depletion decreases proliferation and induces apoptosis in a human colonic adenocarcinoma cell line, Caco2
Authors
Issue Date2009
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jinorgbio
Citation
Journal Of Inorganic Biochemistry, 2009, v. 103 n. 7, p. 1074-1081 How to Cite?
AbstractIron is essential for maintaining cellular metabolism of most organisms. Iron chelators such as desferrioxamine have been used clinically in the treatment of iron overload diseases. In the present study, we used human colon adenocarcinoma cells as a proliferating cell model to validate that desferrioxamine inhibits cell proliferation and induces apoptosis. Proteomic analysis revealed that proteins involved in cell proliferation, signal transduction, metabolism and protein synthesis were significantly regulated by the availability of iron, rendering a close correlation between cell apoptosis and the disturbance of mitochondrial, signaling and metabolic pathways. These results provide new insights into the mechanisms of cell proliferation inhibition attributed to iron depletion. © 2009 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/168384
ISSN
2015 Impact Factor: 3.205
2015 SCImago Journal Rankings: 0.983
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSun, Xen_US
dc.contributor.authorGe, Ren_US
dc.contributor.authorCai, Zen_US
dc.contributor.authorSun, Hen_US
dc.contributor.authorHe, QYen_US
dc.date.accessioned2012-10-08T03:18:15Z-
dc.date.available2012-10-08T03:18:15Z-
dc.date.issued2009en_US
dc.identifier.citationJournal Of Inorganic Biochemistry, 2009, v. 103 n. 7, p. 1074-1081en_US
dc.identifier.issn0162-0134en_US
dc.identifier.urihttp://hdl.handle.net/10722/168384-
dc.description.abstractIron is essential for maintaining cellular metabolism of most organisms. Iron chelators such as desferrioxamine have been used clinically in the treatment of iron overload diseases. In the present study, we used human colon adenocarcinoma cells as a proliferating cell model to validate that desferrioxamine inhibits cell proliferation and induces apoptosis. Proteomic analysis revealed that proteins involved in cell proliferation, signal transduction, metabolism and protein synthesis were significantly regulated by the availability of iron, rendering a close correlation between cell apoptosis and the disturbance of mitochondrial, signaling and metabolic pathways. These results provide new insights into the mechanisms of cell proliferation inhibition attributed to iron depletion. © 2009 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jinorgbioen_US
dc.relation.ispartofJournal of Inorganic Biochemistryen_US
dc.subject.meshApoptosisen_US
dc.subject.meshCaco-2 Cellsen_US
dc.subject.meshCell Proliferation - Drug Effectsen_US
dc.subject.meshDeferoxamine - Pharmacologyen_US
dc.subject.meshDown-Regulationen_US
dc.subject.meshHumansen_US
dc.subject.meshIron - Deficiency - Metabolismen_US
dc.subject.meshIron Chelating Agents - Pharmacologyen_US
dc.subject.meshMembrane Potential, Mitochondrial - Drug Effectsen_US
dc.subject.meshProteome - Drug Effectsen_US
dc.subject.meshSiderophores - Pharmacologyen_US
dc.subject.meshUp-Regulationen_US
dc.titleIron depletion decreases proliferation and induces apoptosis in a human colonic adenocarcinoma cell line, Caco2en_US
dc.typeArticleen_US
dc.identifier.emailSun, H:hsun@hkucc.hku.hken_US
dc.identifier.authoritySun, H=rp00777en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.jinorgbio.2009.05.004en_US
dc.identifier.pmid19515424-
dc.identifier.scopuseid_2-s2.0-67449161823en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67449161823&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume103en_US
dc.identifier.issue7en_US
dc.identifier.spage1074en_US
dc.identifier.epage1081en_US
dc.identifier.isiWOS:000267768200018-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridSun, X=35799316500en_US
dc.identifier.scopusauthoridGe, R=7005525090en_US
dc.identifier.scopusauthoridCai, Z=7402904946en_US
dc.identifier.scopusauthoridSun, H=7404827446en_US
dc.identifier.scopusauthoridHe, QY=34770287900en_US
dc.identifier.citeulike5344365-

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