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Article: Application of H-Cu-P complexes in organic synthesis

TitleApplication of H-Cu-P complexes in organic synthesis
Authors
KeywordsAsymmetric Catalysis
Conjugate Reduction
Α,Β-Unsaturated Compounds
Copper Hydrides
Phosphorous Ligands
Stryker' S Reagents
Issue Date2008
Citation
Progress In Chemistry, 2008, v. 20 n. 12, p. 1909-1922 How to Cite?
AbstractA survey of the literature up to February 2008 on the progress of the preparation of [ HCuPPh3 ]6 and the application of copper hydride-organo phosphine complexes in organic synthesis is presented in this article. As a reductant, [HCuPPh3 ]6 can selectively reduce the C =C double bond in α,β-unsaturated ester, ketone, aldehyde, nitro and nitrile compounds and CξC triple bond in alkyne; as a catalyst, it can promote the reduction of C =C double bonds of aforementioned compounds by hydrogen or silane. The C =C double bond in these compounds or carbonyl group in α,βunsaturated ketone and aldehyde, alkyl aryl ketone can be selectively reduced by changing the phosphorous ligand. By employing suitable chiral phosphorous ligands, high enantioselective reductions of the C = C double bond, C = 0 double bond in prochiral substrates have been achieved. The special reactivity and catalytic activity have been utilized in the synthesis of structurally complex natural products and compounds of biological importance.
Persistent Identifierhttp://hdl.handle.net/10722/168355
ISSN
2015 Impact Factor: 0.894
2015 SCImago Journal Rankings: 0.275
References

 

DC FieldValueLanguage
dc.contributor.authorZhengning, Len_US
dc.contributor.authorGailing, Len_US
dc.contributor.authorChiu, Pen_US
dc.date.accessioned2012-10-08T03:17:54Z-
dc.date.available2012-10-08T03:17:54Z-
dc.date.issued2008en_US
dc.identifier.citationProgress In Chemistry, 2008, v. 20 n. 12, p. 1909-1922en_US
dc.identifier.issn1005-281Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/168355-
dc.description.abstractA survey of the literature up to February 2008 on the progress of the preparation of [ HCuPPh3 ]6 and the application of copper hydride-organo phosphine complexes in organic synthesis is presented in this article. As a reductant, [HCuPPh3 ]6 can selectively reduce the C =C double bond in α,β-unsaturated ester, ketone, aldehyde, nitro and nitrile compounds and CξC triple bond in alkyne; as a catalyst, it can promote the reduction of C =C double bonds of aforementioned compounds by hydrogen or silane. The C =C double bond in these compounds or carbonyl group in α,βunsaturated ketone and aldehyde, alkyl aryl ketone can be selectively reduced by changing the phosphorous ligand. By employing suitable chiral phosphorous ligands, high enantioselective reductions of the C = C double bond, C = 0 double bond in prochiral substrates have been achieved. The special reactivity and catalytic activity have been utilized in the synthesis of structurally complex natural products and compounds of biological importance.en_US
dc.languageengen_US
dc.relation.ispartofProgress in Chemistryen_US
dc.subjectAsymmetric Catalysisen_US
dc.subjectConjugate Reductionen_US
dc.subjectΑ,Β-Unsaturated Compoundsen_US
dc.subjectCopper Hydridesen_US
dc.subjectPhosphorous Ligandsen_US
dc.subjectStryker' S Reagentsen_US
dc.titleApplication of H-Cu-P complexes in organic synthesisen_US
dc.typeArticleen_US
dc.identifier.emailChiu, P:pchiu@hku.hken_US
dc.identifier.authorityChiu, P=rp00680en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-58949090054en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-58949090054&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume20en_US
dc.identifier.issue12en_US
dc.identifier.spage1909en_US
dc.identifier.epage1922en_US
dc.identifier.scopusauthoridZhengning, L=26024540100en_US
dc.identifier.scopusauthoridGailing, L=26024182500en_US
dc.identifier.scopusauthoridChiu, P=11140148700en_US

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