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Article: Cleavage of double-strand DNA by zinc complexes of dicationic 2,2′-dipyridyl derivatives

TitleCleavage of double-strand DNA by zinc complexes of dicationic 2,2′-dipyridyl derivatives
Authors
Issue Date2007
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/dalton
Citation
Dalton Transactions, 2007 n. 12, p. 1250-1254 How to Cite?
AbstractTwo highly charged zinc complexes, [Zn(L1)3](ClO 4)8·4H2O (1) and [Zn(L2) 2Br](ClO4)5·H2O (2) (L 1 = 5,5′-di(1-(triethylammonio)methyl)-2,2′-dipyridyl and L2 = 5,5′-di(1-(tributylammonio)methyl)-2,2′-dipyridyl) were synthesized and structurally characterized by crystallography. The zinc atom in 1 shows a distorted octahedral sphere. Variable-pH NMR studies on 1 demonstrated that the saturated six-coordinated [Zn(L1) 3]8+ species can partially change into five-coordinated [Zn(L1)2(H2O)]6+ species in aqueous solution. The zinc atom in 2 shows a distorted trigonal-bipyramidal sphere. The average distance of the coordinated Br atom to the cationic N atom in 2 is ca 5.9 Å, which is comparable to that of adjacent phosphodiesters in the DNA (ca. 6 Å). Both complexes exhibited high nuclease activities towards cleavage of supercoiled plasmid DNA with the activity being the maximum under physiological pH. The effective DNA cleavage may be attributed to the strong electrostatic interaction of the metal moiety and two positive pendants with phosphodiester groups of nucleic acid. © The Royal Society of Chemistry 2007.
Persistent Identifierhttp://hdl.handle.net/10722/168097
ISSN
2015 Impact Factor: 4.177
2015 SCImago Journal Rankings: 1.404
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAn, Yen_US
dc.contributor.authorLin, YYen_US
dc.contributor.authorWang, Hen_US
dc.contributor.authorSun, HZen_US
dc.contributor.authorTong, MLen_US
dc.contributor.authorJi, LNen_US
dc.contributor.authorMao, ZWen_US
dc.date.accessioned2012-10-08T03:15:03Z-
dc.date.available2012-10-08T03:15:03Z-
dc.date.issued2007en_US
dc.identifier.citationDalton Transactions, 2007 n. 12, p. 1250-1254en_US
dc.identifier.issn1477-9226en_US
dc.identifier.urihttp://hdl.handle.net/10722/168097-
dc.description.abstractTwo highly charged zinc complexes, [Zn(L1)3](ClO 4)8·4H2O (1) and [Zn(L2) 2Br](ClO4)5·H2O (2) (L 1 = 5,5′-di(1-(triethylammonio)methyl)-2,2′-dipyridyl and L2 = 5,5′-di(1-(tributylammonio)methyl)-2,2′-dipyridyl) were synthesized and structurally characterized by crystallography. The zinc atom in 1 shows a distorted octahedral sphere. Variable-pH NMR studies on 1 demonstrated that the saturated six-coordinated [Zn(L1) 3]8+ species can partially change into five-coordinated [Zn(L1)2(H2O)]6+ species in aqueous solution. The zinc atom in 2 shows a distorted trigonal-bipyramidal sphere. The average distance of the coordinated Br atom to the cationic N atom in 2 is ca 5.9 Å, which is comparable to that of adjacent phosphodiesters in the DNA (ca. 6 Å). Both complexes exhibited high nuclease activities towards cleavage of supercoiled plasmid DNA with the activity being the maximum under physiological pH. The effective DNA cleavage may be attributed to the strong electrostatic interaction of the metal moiety and two positive pendants with phosphodiester groups of nucleic acid. © The Royal Society of Chemistry 2007.en_US
dc.languageengen_US
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/daltonen_US
dc.relation.ispartofDalton Transactionsen_US
dc.subject.mesh2,2'-Dipyridyl - Chemistryen_US
dc.subject.meshCrystallography, X-Rayen_US
dc.subject.meshDna - Chemistryen_US
dc.subject.meshHydrogen-Ion Concentrationen_US
dc.subject.meshIndicators And Reagentsen_US
dc.subject.meshMagnetic Resonance Spectroscopyen_US
dc.subject.meshNucleic Acid Conformationen_US
dc.subject.meshPlasmids - Chemistryen_US
dc.subject.meshSpectrometry, Mass, Electrospray Ionizationen_US
dc.subject.meshZinc - Chemistryen_US
dc.titleCleavage of double-strand DNA by zinc complexes of dicationic 2,2′-dipyridyl derivativesen_US
dc.typeArticleen_US
dc.identifier.emailSun, HZ:hsun@hkucc.hku.hken_US
dc.identifier.authoritySun, HZ=rp00777en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1039/b616754cen_US
dc.identifier.pmid17353958-
dc.identifier.scopuseid_2-s2.0-33947119249en_US
dc.identifier.hkuros129937-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33947119249&selection=ref&src=s&origin=recordpageen_US
dc.identifier.issue12en_US
dc.identifier.spage1250en_US
dc.identifier.epage1254en_US
dc.identifier.isiWOS:000244852600010-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridAn, Y=13807351600en_US
dc.identifier.scopusauthoridLin, YY=8938522100en_US
dc.identifier.scopusauthoridWang, H=15052706700en_US
dc.identifier.scopusauthoridSun, HZ=7404827446en_US
dc.identifier.scopusauthoridTong, ML=7202033871en_US
dc.identifier.scopusauthoridJi, LN=7201376856en_US
dc.identifier.scopusauthoridMao, ZW=7202633935en_US

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