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Article: Diastereomeric salt crystallization synthesis for chiral resolution of ibuprofen
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TitleDiastereomeric salt crystallization synthesis for chiral resolution of ibuprofen
 
AuthorsLam, WH1
Ng, KM1
 
KeywordsDiastereomeric Salt Crystallization Processes
Ibuprofen Resolution
Process Synthesis
Seeding
Solid-Liquid Equilibrium Phase Diagram
 
Issue Date2007
 
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.aiche.org
 
CitationAiche Journal, 2007, v. 53 n. 2, p. 429-437 [How to Cite?]
DOI: http://dx.doi.org/10.1002/aic.11087
 
AbstractConceptual design and experimental investigations are integrated for synthesizing diastereomeric salt crystallization processes for chiral resolution. An anti-inflammatory drug ibuprofen and a common resolving agent N-methyl-D-glucamine were chosen to illustrate this integrative approach. Bench data were generated in a systematic manner. Solvent screening was conducted first to identify the right solvent to precipitate the diastereomeric salts. Solid - liquid equilibrium data of the diastereomeric salt system were then measured. Seeding was used to facilitate the precipitation of the desired component. All of this information was used to generate flow sheet alternatives to recover the desired diastereomeric salts. © 2007 American Institute of Chemical Engineers.
 
ISSN0001-1541
2013 Impact Factor: 2.581
 
DOIhttp://dx.doi.org/10.1002/aic.11087
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLam, WH
 
dc.contributor.authorNg, KM
 
dc.date.accessioned2012-10-08T03:15:00Z
 
dc.date.available2012-10-08T03:15:00Z
 
dc.date.issued2007
 
dc.description.abstractConceptual design and experimental investigations are integrated for synthesizing diastereomeric salt crystallization processes for chiral resolution. An anti-inflammatory drug ibuprofen and a common resolving agent N-methyl-D-glucamine were chosen to illustrate this integrative approach. Bench data were generated in a systematic manner. Solvent screening was conducted first to identify the right solvent to precipitate the diastereomeric salts. Solid - liquid equilibrium data of the diastereomeric salt system were then measured. Seeding was used to facilitate the precipitation of the desired component. All of this information was used to generate flow sheet alternatives to recover the desired diastereomeric salts. © 2007 American Institute of Chemical Engineers.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationAiche Journal, 2007, v. 53 n. 2, p. 429-437 [How to Cite?]
DOI: http://dx.doi.org/10.1002/aic.11087
 
dc.identifier.doihttp://dx.doi.org/10.1002/aic.11087
 
dc.identifier.epage437
 
dc.identifier.issn0001-1541
2013 Impact Factor: 2.581
 
dc.identifier.issue2
 
dc.identifier.scopuseid_2-s2.0-33846865091
 
dc.identifier.spage429
 
dc.identifier.urihttp://hdl.handle.net/10722/168094
 
dc.identifier.volume53
 
dc.languageeng
 
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.aiche.org
 
dc.publisher.placeUnited States
 
dc.relation.ispartofAIChE Journal
 
dc.relation.referencesReferences in Scopus
 
dc.subjectDiastereomeric Salt Crystallization Processes
 
dc.subjectIbuprofen Resolution
 
dc.subjectProcess Synthesis
 
dc.subjectSeeding
 
dc.subjectSolid-Liquid Equilibrium Phase Diagram
 
dc.titleDiastereomeric salt crystallization synthesis for chiral resolution of ibuprofen
 
dc.typeArticle
 
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Author Affiliations
  1. Hong Kong University of Science and Technology