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Article: Diastereomeric salt crystallization synthesis for chiral resolution of ibuprofen

TitleDiastereomeric salt crystallization synthesis for chiral resolution of ibuprofen
Authors
KeywordsDiastereomeric Salt Crystallization Processes
Ibuprofen Resolution
Process Synthesis
Seeding
Solid-Liquid Equilibrium Phase Diagram
Issue Date2007
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.aiche.org
Citation
Aiche Journal, 2007, v. 53 n. 2, p. 429-437 How to Cite?
Abstract
Conceptual design and experimental investigations are integrated for synthesizing diastereomeric salt crystallization processes for chiral resolution. An anti-inflammatory drug ibuprofen and a common resolving agent N-methyl-D-glucamine were chosen to illustrate this integrative approach. Bench data were generated in a systematic manner. Solvent screening was conducted first to identify the right solvent to precipitate the diastereomeric salts. Solid - liquid equilibrium data of the diastereomeric salt system were then measured. Seeding was used to facilitate the precipitation of the desired component. All of this information was used to generate flow sheet alternatives to recover the desired diastereomeric salts. © 2007 American Institute of Chemical Engineers.
Persistent Identifierhttp://hdl.handle.net/10722/168094
ISSN
2013 Impact Factor: 2.581
ISI Accession Number ID
References

 

Author Affiliations
  1. Hong Kong University of Science and Technology
DC FieldValueLanguage
dc.contributor.authorLam, WHen_US
dc.contributor.authorNg, KMen_US
dc.date.accessioned2012-10-08T03:15:00Z-
dc.date.available2012-10-08T03:15:00Z-
dc.date.issued2007en_US
dc.identifier.citationAiche Journal, 2007, v. 53 n. 2, p. 429-437en_US
dc.identifier.issn0001-1541en_US
dc.identifier.urihttp://hdl.handle.net/10722/168094-
dc.description.abstractConceptual design and experimental investigations are integrated for synthesizing diastereomeric salt crystallization processes for chiral resolution. An anti-inflammatory drug ibuprofen and a common resolving agent N-methyl-D-glucamine were chosen to illustrate this integrative approach. Bench data were generated in a systematic manner. Solvent screening was conducted first to identify the right solvent to precipitate the diastereomeric salts. Solid - liquid equilibrium data of the diastereomeric salt system were then measured. Seeding was used to facilitate the precipitation of the desired component. All of this information was used to generate flow sheet alternatives to recover the desired diastereomeric salts. © 2007 American Institute of Chemical Engineers.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.aiche.orgen_US
dc.relation.ispartofAIChE Journalen_US
dc.subjectDiastereomeric Salt Crystallization Processesen_US
dc.subjectIbuprofen Resolutionen_US
dc.subjectProcess Synthesisen_US
dc.subjectSeedingen_US
dc.subjectSolid-Liquid Equilibrium Phase Diagramen_US
dc.titleDiastereomeric salt crystallization synthesis for chiral resolution of ibuprofenen_US
dc.typeArticleen_US
dc.identifier.emailLam, WH:chsue@hku.hken_US
dc.identifier.authorityLam, WH=rp00719en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/aic.11087en_US
dc.identifier.scopuseid_2-s2.0-33846865091en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33846865091&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume53en_US
dc.identifier.issue2en_US
dc.identifier.spage429en_US
dc.identifier.epage437en_US
dc.identifier.isiWOS:000243672200015-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLam, WH=26642862800en_US
dc.identifier.scopusauthoridNg, KM=7403178419en_US

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