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Article: An insight of S-nitrosylation of human GIF

TitleAn insight of S-nitrosylation of human GIF
Authors
KeywordsAcid-Base Catalysis
Growth Inhibitory Factor
Metallothionein
S-Nitrosylation
Issue Date2005
PublisherZhongguo Kexueyuan, Shanghai Youji Huaxue Yanjiusuo. The Journal's web site is located at http://www.sioc-journal.cn/zghx/index_en.asp
Citation
Chinese Journal Of Chemistry, 2005, v. 23 n. 11, p. 1545-1551 How to Cite?
AbstractNeural growth inhibitory factor (GIF), a member of metallothionein family (metallothionein-3, MT3), was well known by its distinct neural growth inhibitory activity, which is not shown by other MT isoforms. However, till now, people still did not know clearly how GIF exerts its biological functions. Since it has been reported that GIF might serve as NO scavenger and was related to the release of zinc, our study was focused on the interaction of GIF and NO. By studying the reactions of human GIF and human MT1g with SNOC - a type of NO donor, it was found that GIF was more reactive than MT-1g toward SNOC. In order to further figure out if the high reactivity of GIF in this reaction resulted from the acid-base catalysis, several mutants were constructed: E23K, E41G/E43A, E23K/E41G/E43A. By studying their basic properties and the reactions toward SNOC, it was found that the S-nitrosylation of GIF was not only related to the acid-base catalysis, but also to the accessibility of metal-thiolate clusters. © 2005 SIOC, CAS, & Wiley-VCH Verlag GmbH & Co. KGaA.
Persistent Identifierhttp://hdl.handle.net/10722/167979
ISSN
2015 Impact Factor: 1.872
2015 SCImago Journal Rankings: 0.441
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTeng, XCen_US
dc.contributor.authorZheng, Qen_US
dc.contributor.authorCai, Ben_US
dc.contributor.authorNi, FYen_US
dc.contributor.authorXie, Yen_US
dc.contributor.authorSun, HZen_US
dc.contributor.authorZhang, MJen_US
dc.contributor.authorHuang, ZXen_US
dc.date.accessioned2012-10-08T03:13:40Z-
dc.date.available2012-10-08T03:13:40Z-
dc.date.issued2005en_US
dc.identifier.citationChinese Journal Of Chemistry, 2005, v. 23 n. 11, p. 1545-1551en_US
dc.identifier.issn1001-604Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/167979-
dc.description.abstractNeural growth inhibitory factor (GIF), a member of metallothionein family (metallothionein-3, MT3), was well known by its distinct neural growth inhibitory activity, which is not shown by other MT isoforms. However, till now, people still did not know clearly how GIF exerts its biological functions. Since it has been reported that GIF might serve as NO scavenger and was related to the release of zinc, our study was focused on the interaction of GIF and NO. By studying the reactions of human GIF and human MT1g with SNOC - a type of NO donor, it was found that GIF was more reactive than MT-1g toward SNOC. In order to further figure out if the high reactivity of GIF in this reaction resulted from the acid-base catalysis, several mutants were constructed: E23K, E41G/E43A, E23K/E41G/E43A. By studying their basic properties and the reactions toward SNOC, it was found that the S-nitrosylation of GIF was not only related to the acid-base catalysis, but also to the accessibility of metal-thiolate clusters. © 2005 SIOC, CAS, & Wiley-VCH Verlag GmbH & Co. KGaA.en_US
dc.languageengen_US
dc.publisherZhongguo Kexueyuan, Shanghai Youji Huaxue Yanjiusuo. The Journal's web site is located at http://www.sioc-journal.cn/zghx/index_en.aspen_US
dc.relation.ispartofChinese Journal of Chemistryen_US
dc.subjectAcid-Base Catalysisen_US
dc.subjectGrowth Inhibitory Factoren_US
dc.subjectMetallothioneinen_US
dc.subjectS-Nitrosylationen_US
dc.titleAn insight of S-nitrosylation of human GIFen_US
dc.typeArticleen_US
dc.identifier.emailSun, HZ:hsun@hkucc.hku.hken_US
dc.identifier.authoritySun, HZ=rp00777en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/cjoc.200591545en_US
dc.identifier.scopuseid_2-s2.0-28844465399en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-28844465399&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume23en_US
dc.identifier.issue11en_US
dc.identifier.spage1545en_US
dc.identifier.epage1551en_US
dc.identifier.isiWOS:000232999200016-
dc.publisher.placeChinaen_US
dc.identifier.scopusauthoridTeng, XC=9842935500en_US
dc.identifier.scopusauthoridZheng, Q=36887872800en_US
dc.identifier.scopusauthoridCai, B=36484162900en_US
dc.identifier.scopusauthoridNi, FY=9841840800en_US
dc.identifier.scopusauthoridXie, Y=36121797300en_US
dc.identifier.scopusauthoridSun, HZ=7404827446en_US
dc.identifier.scopusauthoridZhang, MJ=7601555100en_US
dc.identifier.scopusauthoridHuang, ZX=7406221847en_US

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