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Article: Synthesis and biological evaluation of novel compounds related to 1-arylnaphthalene lignans and isoquinolines

TitleSynthesis and biological evaluation of novel compounds related to 1-arylnaphthalene lignans and isoquinolines
Authors
Issue Date2005
PublisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/106056929
Citation
Chemistry And Biodiversity, 2005, v. 2 n. 9, p. 1217-1231 How to Cite?
AbstractNovel compounds designed as hybrids of 1-arylnaphthalene lignans with isoquinoline alkaloids were prepared and evaluated for their cytotoxicities on human tumor cell lines, such as A549, Hela, PC-3, CNE, BEL-7404, and KB. Some of the synthetic compounds exhibited their IC 50 values on selected cell lines at 10 -6 m scale. The preliminary CoMFA molecular-modelling studies of these synthetic analogues were also performed. © 2005 Verlag Helvetica Chimica Acta AG, Zürich.
Persistent Identifierhttp://hdl.handle.net/10722/167959
ISSN
2015 Impact Factor: 1.444
2015 SCImago Journal Rankings: 0.542
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDing, Hen_US
dc.contributor.authorLu, Wen_US
dc.contributor.authorLi, Hen_US
dc.contributor.authorYang, Len_US
dc.contributor.authorZhang, Qen_US
dc.contributor.authorZhou, Cen_US
dc.contributor.authorWu, Xen_US
dc.contributor.authorBaudoin, Oen_US
dc.contributor.authorCai, Jen_US
dc.contributor.authorGuéritte, Fen_US
dc.contributor.authorZhao, Yen_US
dc.date.accessioned2012-10-08T03:13:26Z-
dc.date.available2012-10-08T03:13:26Z-
dc.date.issued2005en_US
dc.identifier.citationChemistry And Biodiversity, 2005, v. 2 n. 9, p. 1217-1231en_US
dc.identifier.issn1612-1872en_US
dc.identifier.urihttp://hdl.handle.net/10722/167959-
dc.description.abstractNovel compounds designed as hybrids of 1-arylnaphthalene lignans with isoquinoline alkaloids were prepared and evaluated for their cytotoxicities on human tumor cell lines, such as A549, Hela, PC-3, CNE, BEL-7404, and KB. Some of the synthetic compounds exhibited their IC 50 values on selected cell lines at 10 -6 m scale. The preliminary CoMFA molecular-modelling studies of these synthetic analogues were also performed. © 2005 Verlag Helvetica Chimica Acta AG, Zürich.en_US
dc.languageengen_US
dc.publisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/106056929en_US
dc.relation.ispartofChemistry and Biodiversityen_US
dc.subject.meshAntineoplastic Agents - Chemistry - Pharmacologyen_US
dc.subject.meshCell Line, Tumoren_US
dc.subject.meshHumansen_US
dc.subject.meshIsoquinolines - Chemistry - Pharmacologyen_US
dc.subject.meshLignans - Chemistry - Pharmacologyen_US
dc.subject.meshModels, Molecularen_US
dc.subject.meshMolecular Structureen_US
dc.titleSynthesis and biological evaluation of novel compounds related to 1-arylnaphthalene lignans and isoquinolinesen_US
dc.typeArticleen_US
dc.identifier.emailLu, W:luwei@hku.hken_US
dc.identifier.authorityLu, W=rp00754en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/cbdv.200590092en_US
dc.identifier.pmid17193204-
dc.identifier.scopuseid_2-s2.0-26044436557en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-26044436557&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume2en_US
dc.identifier.issue9en_US
dc.identifier.spage1217en_US
dc.identifier.epage1231en_US
dc.identifier.isiWOS:000232226900009-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridDing, H=24400944500en_US
dc.identifier.scopusauthoridLu, W=27868087600en_US
dc.identifier.scopusauthoridLi, H=40861398300en_US
dc.identifier.scopusauthoridYang, L=8356794700en_US
dc.identifier.scopusauthoridZhang, Q=7406715139en_US
dc.identifier.scopusauthoridZhou, C=7403347317en_US
dc.identifier.scopusauthoridWu, X=12144456600en_US
dc.identifier.scopusauthoridBaudoin, O=6601962392en_US
dc.identifier.scopusauthoridCai, J=26643616800en_US
dc.identifier.scopusauthoridGuéritte, F=7004196029en_US
dc.identifier.scopusauthoridZhao, Y=7406634118en_US

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