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Article: Transferrin-mediated gold nanoparticle cellular uptake

TitleTransferrin-mediated gold nanoparticle cellular uptake
Authors
Issue Date2005
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/bc
Citation
Bioconjugate Chemistry, 2005, v. 16 n. 3, p. 494-496 How to Cite?
AbstractTargeted drug delivery is an important research area in specific therapy. Transferrin-conjugated nanoparticles are an attractive formulation as a vehicle for specific cellular uptake and targeted drug delivery. In this report, atomic force microscopy imaging was used to visualize the process of cellular uptake of transferrin-coupled gold nanoparticles on the surfaces of live cells for the first time. High-resolution images were captured, showing the endocytosis of transferrin-conjugated nanoparticles taking place during the process of internalization. This specific transferrin-mediated nanoparticle uptake was validated by confocal scanning imaging and transferrin competition experiments. © 2005 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/167924
ISSN
2015 Impact Factor: 4.5
2015 SCImago Journal Rankings: 1.754
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYang, PHen_US
dc.contributor.authorSun, Xen_US
dc.contributor.authorChiu, JFen_US
dc.contributor.authorSun, Hen_US
dc.contributor.authorHe, QYen_US
dc.date.accessioned2012-10-08T03:12:59Z-
dc.date.available2012-10-08T03:12:59Z-
dc.date.issued2005en_US
dc.identifier.citationBioconjugate Chemistry, 2005, v. 16 n. 3, p. 494-496en_US
dc.identifier.issn1043-1802en_US
dc.identifier.urihttp://hdl.handle.net/10722/167924-
dc.description.abstractTargeted drug delivery is an important research area in specific therapy. Transferrin-conjugated nanoparticles are an attractive formulation as a vehicle for specific cellular uptake and targeted drug delivery. In this report, atomic force microscopy imaging was used to visualize the process of cellular uptake of transferrin-coupled gold nanoparticles on the surfaces of live cells for the first time. High-resolution images were captured, showing the endocytosis of transferrin-conjugated nanoparticles taking place during the process of internalization. This specific transferrin-mediated nanoparticle uptake was validated by confocal scanning imaging and transferrin competition experiments. © 2005 American Chemical Society.en_US
dc.languageengen_US
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/bcen_US
dc.relation.ispartofBioconjugate Chemistryen_US
dc.subject.meshBiological Transporten_US
dc.subject.meshCell Line, Tumoren_US
dc.subject.meshGold - Chemistry - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshMicroscopy, Atomic Forceen_US
dc.subject.meshMicroscopy, Confocalen_US
dc.subject.meshNanostructures - Ultrastructureen_US
dc.subject.meshTransferrin - Chemistry - Metabolism - Ultrastructureen_US
dc.titleTransferrin-mediated gold nanoparticle cellular uptakeen_US
dc.typeArticleen_US
dc.identifier.emailSun, H:hsun@hkucc.hku.hken_US
dc.identifier.authoritySun, H=rp00777en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1021/bc049775den_US
dc.identifier.pmid15898713-
dc.identifier.scopuseid_2-s2.0-18844389263en_US
dc.identifier.hkuros98471-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-18844389263&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume16en_US
dc.identifier.issue3en_US
dc.identifier.spage494en_US
dc.identifier.epage496en_US
dc.identifier.isiWOS:000229274800003-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridYang, PH=8847694800en_US
dc.identifier.scopusauthoridSun, X=8906547400en_US
dc.identifier.scopusauthoridChiu, JF=7201501692en_US
dc.identifier.scopusauthoridSun, H=7404827446en_US
dc.identifier.scopusauthoridHe, QY=34770287900en_US

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