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Article: Capillary zone electrophoresis investigation of the interaction between heparin and granulocyte-colony stimulating factor

TitleCapillary zone electrophoresis investigation of the interaction between heparin and granulocyte-colony stimulating factor
Authors
Issue Date2004
PublisherWiley - V C H Verlag GmbH & Co KGaA.
Citation
Electrophoresis, 2004, v. 25 n. 6, p. 870-875 How to Cite?
AbstractThe interaction between standard heparin, low-molecular-weight heparin (LMWH), and granulocyte-colony stimulating factor (G-CSF) was studied by capillary zone electrophoresis. Both qualitative and quantitative characterizations of the heparin-protein binding were determined. The binding constants of the two different groups of heparins with G-CSF, calculated from the Scatchard plot by regression, were 4.805 × 105 M-1 and 4.579 × 105 M-1, respectively. The two binding constants measured are of the same order of magnitude at 105 M-1, indicating that LMWH contains most of the functional groups bound to G-CSF by standard heparin. © 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Persistent Identifierhttp://hdl.handle.net/10722/167906
ISSN
2015 Impact Factor: 2.482
2015 SCImago Journal Rankings: 0.896
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiang, Aen_US
dc.contributor.authorHe, Xen_US
dc.contributor.authorDu, Yen_US
dc.contributor.authorWang, Ken_US
dc.contributor.authorFung, Yen_US
dc.contributor.authorLin, Ben_US
dc.date.accessioned2012-10-08T03:12:47Z-
dc.date.available2012-10-08T03:12:47Z-
dc.date.issued2004en_US
dc.identifier.citationElectrophoresis, 2004, v. 25 n. 6, p. 870-875en_US
dc.identifier.issn0173-0835en_US
dc.identifier.urihttp://hdl.handle.net/10722/167906-
dc.description.abstractThe interaction between standard heparin, low-molecular-weight heparin (LMWH), and granulocyte-colony stimulating factor (G-CSF) was studied by capillary zone electrophoresis. Both qualitative and quantitative characterizations of the heparin-protein binding were determined. The binding constants of the two different groups of heparins with G-CSF, calculated from the Scatchard plot by regression, were 4.805 × 105 M-1 and 4.579 × 105 M-1, respectively. The two binding constants measured are of the same order of magnitude at 105 M-1, indicating that LMWH contains most of the functional groups bound to G-CSF by standard heparin. © 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.en_US
dc.languageengen_US
dc.publisherWiley - V C H Verlag GmbH & Co KGaA.-
dc.relation.ispartofElectrophoresisen_US
dc.subject.meshElectrophoresis, Capillary - Methodsen_US
dc.subject.meshGranulocyte Colony-Stimulating Factor - Chemistry - Metabolismen_US
dc.subject.meshHeparin - Chemistry - Metabolismen_US
dc.subject.meshHeparin, Low-Molecular-Weight - Chemistry - Metabolismen_US
dc.subject.meshOsmolar Concentrationen_US
dc.subject.meshProtein Bindingen_US
dc.titleCapillary zone electrophoresis investigation of the interaction between heparin and granulocyte-colony stimulating factoren_US
dc.typeArticleen_US
dc.identifier.emailFung, Y:ysfung@hku.hken_US
dc.identifier.authorityFung, Y=rp00697en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/elps.200305728en_US
dc.identifier.pmid15004848-
dc.identifier.scopuseid_2-s2.0-1642485197en_US
dc.identifier.hkuros93168-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1642485197&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume25en_US
dc.identifier.issue6en_US
dc.identifier.spage870en_US
dc.identifier.epage875en_US
dc.identifier.isiWOS:000220347900014-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridLiang, A=7103265241en_US
dc.identifier.scopusauthoridHe, X=7404408765en_US
dc.identifier.scopusauthoridDu, Y=7402894093en_US
dc.identifier.scopusauthoridWang, K=7501400830en_US
dc.identifier.scopusauthoridFung, Y=13309754700en_US
dc.identifier.scopusauthoridLin, B=34668182800en_US

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