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Article: Synthesis of a carbohydrate-derived hydroxamic acid inhibitor of the bacterial enzyme (LpxC) involved in lipid A biosynthesis

TitleSynthesis of a carbohydrate-derived hydroxamic acid inhibitor of the bacterial enzyme (LpxC) involved in lipid A biosynthesis
Authors
Issue Date2003
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/orlef7/index.html
Citation
Organic Letters, 2003, v. 5 n. 4, p. 539-541 How to Cite?
Abstract(Matrix presented) The enzyme LpxC (UDP-3-O-[(R)-3-hydroxymyristoyl] -GlcNAc deacetylase) catalyzes the second step of lipid A biosynthesis and is essential for bacterial growth. A GlcNAc-derived hydroxamic acid inhibitor 8 of this enzyme was synthesized using two different routes. Compound 8 exhibits activity toward LpxC enzymes from a wider spectrum of bacterial species than any of the previously reported hydroxamic acid inhibitors.
Persistent Identifierhttp://hdl.handle.net/10722/167800
ISSN
2015 Impact Factor: 6.732
2015 SCImago Journal Rankings: 3.187
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, Xen_US
dc.contributor.authorUchiyama, Ten_US
dc.contributor.authorRaetz, CRHen_US
dc.contributor.authorHindsgaul, Oen_US
dc.date.accessioned2012-10-08T03:11:46Z-
dc.date.available2012-10-08T03:11:46Z-
dc.date.issued2003en_US
dc.identifier.citationOrganic Letters, 2003, v. 5 n. 4, p. 539-541en_US
dc.identifier.issn1523-7060en_US
dc.identifier.urihttp://hdl.handle.net/10722/167800-
dc.description.abstract(Matrix presented) The enzyme LpxC (UDP-3-O-[(R)-3-hydroxymyristoyl] -GlcNAc deacetylase) catalyzes the second step of lipid A biosynthesis and is essential for bacterial growth. A GlcNAc-derived hydroxamic acid inhibitor 8 of this enzyme was synthesized using two different routes. Compound 8 exhibits activity toward LpxC enzymes from a wider spectrum of bacterial species than any of the previously reported hydroxamic acid inhibitors.en_US
dc.languageengen_US
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/orlef7/index.htmlen_US
dc.relation.ispartofOrganic Lettersen_US
dc.subject.meshAmidohydrolases - Antagonists & Inhibitorsen_US
dc.subject.meshCarbohydrates - Chemistryen_US
dc.subject.meshEnzyme Inhibitors - Chemical Synthesisen_US
dc.subject.meshEscherichia Coli Proteins - Antagonists & Inhibitorsen_US
dc.subject.meshHydroxamic Acids - Chemical Synthesis - Pharmacologyen_US
dc.subject.meshLipid A - Antagonists & Inhibitors - Biosynthesisen_US
dc.titleSynthesis of a carbohydrate-derived hydroxamic acid inhibitor of the bacterial enzyme (LpxC) involved in lipid A biosynthesisen_US
dc.typeArticleen_US
dc.identifier.emailLi, X:xuechenl@hku.hken_US
dc.identifier.authorityLi, X=rp00742en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1021/ol027458len_US
dc.identifier.pmid12583763-
dc.identifier.scopuseid_2-s2.0-0038345084en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0038345084&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume5en_US
dc.identifier.issue4en_US
dc.identifier.spage539en_US
dc.identifier.epage541en_US
dc.identifier.isiWOS:000181077200040-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLi, X=24168958800en_US
dc.identifier.scopusauthoridUchiyama, T=7402391378en_US
dc.identifier.scopusauthoridRaetz, CRH=7102514726en_US
dc.identifier.scopusauthoridHindsgaul, O=7102966220en_US

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