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Article: Syntheses of ruthenium(II) quinonediimine complexes of cyclam and characterization of their DNA-binding activities and cytotoxicity

TitleSyntheses of ruthenium(II) quinonediimine complexes of cyclam and characterization of their DNA-binding activities and cytotoxicity
Authors
Issue Date2002
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/ic
Citation
Inorganic Chemistry, 2002, v. 41 n. 12, p. 3161-3171 How to Cite?
AbstractThe synthesis and characterization of ruthenium(II) complexes, [Ru(cyclam)(bqdi)]·ZnCl4 (1·ZnCl 4; cyclam = 1,4,8,11-tetraazacyclotetradecane, bqdi = o-benzoquinonediimine), [Ru(cyclam)(nqdi)l·(ClO 4) 2 (2·(ClO 4) 2 nqdi = 2,3- naphthoquinonediimine), and [Ru(cyclam)(phi)]·(ClO 4) 2 (3·(ClO 4) 2); phi = 9,10- phenanthroquinonediimine), are described. The DNA binding properties and biological activity of the Ru(II) complexes were studied by various biophysical and cytological techniques. As expected, only 3 showed significant binding with DNA. The thermodynamic profile of the binding of 3 and DNA was constructed by analyzing the experimental data of absorption titration and UV melting studies with the McGhee equation, van't Hoff's equation, and the Gibbs-Helmholtz equation. Compound 3 binds double-stranded DNA with a binding constant of 5.0 × 10 4 M -1 at 20 °C, and the binding mode of the complex to DNA was proved to be intercalative. Cytotoxicity and induced type of cell death of 1-3 were also investigated. Basically, metal complexes with ligands of molecular shape closely related to the structure of DNA are more likely to bind DNA and possess higher toxicity.
Persistent Identifierhttp://hdl.handle.net/10722/167759
ISSN
2015 Impact Factor: 4.82
2015 SCImago Journal Rankings: 1.873
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, HLen_US
dc.contributor.authorLiu, HQen_US
dc.contributor.authorTzeng, BCen_US
dc.contributor.authorYou, YSen_US
dc.contributor.authorPeng, SMen_US
dc.contributor.authorYang, Men_US
dc.contributor.authorChe, CMen_US
dc.date.accessioned2012-10-08T03:11:06Z-
dc.date.available2012-10-08T03:11:06Z-
dc.date.issued2002en_US
dc.identifier.citationInorganic Chemistry, 2002, v. 41 n. 12, p. 3161-3171en_US
dc.identifier.issn0020-1669en_US
dc.identifier.urihttp://hdl.handle.net/10722/167759-
dc.description.abstractThe synthesis and characterization of ruthenium(II) complexes, [Ru(cyclam)(bqdi)]·ZnCl4 (1·ZnCl 4; cyclam = 1,4,8,11-tetraazacyclotetradecane, bqdi = o-benzoquinonediimine), [Ru(cyclam)(nqdi)l·(ClO 4) 2 (2·(ClO 4) 2 nqdi = 2,3- naphthoquinonediimine), and [Ru(cyclam)(phi)]·(ClO 4) 2 (3·(ClO 4) 2); phi = 9,10- phenanthroquinonediimine), are described. The DNA binding properties and biological activity of the Ru(II) complexes were studied by various biophysical and cytological techniques. As expected, only 3 showed significant binding with DNA. The thermodynamic profile of the binding of 3 and DNA was constructed by analyzing the experimental data of absorption titration and UV melting studies with the McGhee equation, van't Hoff's equation, and the Gibbs-Helmholtz equation. Compound 3 binds double-stranded DNA with a binding constant of 5.0 × 10 4 M -1 at 20 °C, and the binding mode of the complex to DNA was proved to be intercalative. Cytotoxicity and induced type of cell death of 1-3 were also investigated. Basically, metal complexes with ligands of molecular shape closely related to the structure of DNA are more likely to bind DNA and possess higher toxicity.en_US
dc.languageengen_US
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/icen_US
dc.relation.ispartofInorganic Chemistryen_US
dc.titleSyntheses of ruthenium(II) quinonediimine complexes of cyclam and characterization of their DNA-binding activities and cytotoxicityen_US
dc.typeArticleen_US
dc.identifier.emailChe, CM:cmche@hku.hken_US
dc.identifier.authorityChe, CM=rp00670en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1021/ic0112802en_US
dc.identifier.pmid12054995-
dc.identifier.scopuseid_2-s2.0-0037124236en_US
dc.identifier.hkuros76370-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037124236&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume41en_US
dc.identifier.issue12en_US
dc.identifier.spage3161en_US
dc.identifier.epage3171en_US
dc.identifier.isiWOS:000176219400014-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChan, HL=7403402315en_US
dc.identifier.scopusauthoridLiu, HQ=26662466100en_US
dc.identifier.scopusauthoridTzeng, BC=36878810300en_US
dc.identifier.scopusauthoridYou, YS=36870138400en_US
dc.identifier.scopusauthoridPeng, SM=35464852200en_US
dc.identifier.scopusauthoridYang, M=35204210300en_US
dc.identifier.scopusauthoridChe, CM=7102442791en_US

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