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Article: Use of indapamide in hospital and community clinics and its effect on plasma potassium in Chinese patients

TitleUse of indapamide in hospital and community clinics and its effect on plasma potassium in Chinese patients
Authors
Issue Date1998
Citation
Journal Of Clinical Pharmacy And Therapeutics, 1998, v. 23 n. 4, p. 295-302 How to Cite?
AbstractObjectives: To investigate the usage pattern of indapamide and other antihypertensive drugs in patients attending a community-based government outpatient clinic (GOPC) or a hospital-based specialist clinic (SC). The plasma potassium concentrations of patients receiving indapamide and other diuretics were also examined. Method: Prescriptions from the SC and the GOPC were reviewed and collected during January 1998. Patients' plasma potassium concentrations and the date of initiation of each medication were retrieved from the hospital computer databases at SC. An age- and sex-matched control group of patients on non-diuretic antihypertensive drugs was identified. Results: A total of 1648 and 773 prescriptions were collected from the SC during a 1-week period and GOPC during a 1-month period, respectively. Approximately half (45%) of the patients received antihypertensive treatment. Indapamide was five times more frequently prescribed in GOPC than SC (84.7 vs. 17.7%, P < 0.001). Calcium channel blocking agents were the commonest antihypertensive drugs used in both clinics. The mean plasma potassium concentration of patients taking indapamide was lower than that of the control group (P = 0.037). Multiple linear regression analysis showed that consumption of indapamide (P = 0.002) and duration of diuretic therapy (P = 0.023) were significantly related to changes in plasma potassium concentrations [multiple regression equation for potassium level = 4.09 - 0.145 (thiazide = 1) - 0.377 (indapamide = 1) - 0.00468 (duration of diuretic therapy in months)]. Conclusion: Indapamide was used extensively in the community clinic and less in the hospital-based outpatient clinic. Patients receiving indapamide had a significantly lower plasma potassium concentration as compared to other diuretics or antihypertensive groups and this was predicted by a multiple linear regression model. Monitoring plasma electrolytes before initiation of indapamide treatment and at regular intervals thereafter is essential for detecting the hypokalaemia that may occur in Chinese patients.
Persistent Identifierhttp://hdl.handle.net/10722/167581
ISSN
2015 Impact Factor: 1.833
2015 SCImago Journal Rankings: 0.638
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChang, Sen_US
dc.contributor.authorChan, WHen_US
dc.contributor.authorKong, Yen_US
dc.contributor.authorChan, GMCen_US
dc.contributor.authorRaymond, Ken_US
dc.contributor.authorLee, Aen_US
dc.contributor.authorLee, SCen_US
dc.contributor.authorCritchley, JAJHen_US
dc.contributor.authorChan, JCNen_US
dc.date.accessioned2012-10-08T03:08:45Z-
dc.date.available2012-10-08T03:08:45Z-
dc.date.issued1998en_US
dc.identifier.citationJournal Of Clinical Pharmacy And Therapeutics, 1998, v. 23 n. 4, p. 295-302en_US
dc.identifier.issn0269-4727en_US
dc.identifier.urihttp://hdl.handle.net/10722/167581-
dc.description.abstractObjectives: To investigate the usage pattern of indapamide and other antihypertensive drugs in patients attending a community-based government outpatient clinic (GOPC) or a hospital-based specialist clinic (SC). The plasma potassium concentrations of patients receiving indapamide and other diuretics were also examined. Method: Prescriptions from the SC and the GOPC were reviewed and collected during January 1998. Patients' plasma potassium concentrations and the date of initiation of each medication were retrieved from the hospital computer databases at SC. An age- and sex-matched control group of patients on non-diuretic antihypertensive drugs was identified. Results: A total of 1648 and 773 prescriptions were collected from the SC during a 1-week period and GOPC during a 1-month period, respectively. Approximately half (45%) of the patients received antihypertensive treatment. Indapamide was five times more frequently prescribed in GOPC than SC (84.7 vs. 17.7%, P < 0.001). Calcium channel blocking agents were the commonest antihypertensive drugs used in both clinics. The mean plasma potassium concentration of patients taking indapamide was lower than that of the control group (P = 0.037). Multiple linear regression analysis showed that consumption of indapamide (P = 0.002) and duration of diuretic therapy (P = 0.023) were significantly related to changes in plasma potassium concentrations [multiple regression equation for potassium level = 4.09 - 0.145 (thiazide = 1) - 0.377 (indapamide = 1) - 0.00468 (duration of diuretic therapy in months)]. Conclusion: Indapamide was used extensively in the community clinic and less in the hospital-based outpatient clinic. Patients receiving indapamide had a significantly lower plasma potassium concentration as compared to other diuretics or antihypertensive groups and this was predicted by a multiple linear regression model. Monitoring plasma electrolytes before initiation of indapamide treatment and at regular intervals thereafter is essential for detecting the hypokalaemia that may occur in Chinese patients.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Clinical Pharmacy and Therapeuticsen_US
dc.subject.meshAgeden_US
dc.subject.meshAntihypertensive Agents - Adverse Effectsen_US
dc.subject.meshAsian Continental Ancestry Groupen_US
dc.subject.meshData Interpretation, Statisticalen_US
dc.subject.meshDiuretics - Adverse Effectsen_US
dc.subject.meshDrug Prescriptions - Statistics & Numerical Dataen_US
dc.subject.meshDrug Utilizationen_US
dc.subject.meshFemaleen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHospitals, Teachingen_US
dc.subject.meshHumansen_US
dc.subject.meshHypokalemia - Chemically Induced - Ethnologyen_US
dc.subject.meshIndapamide - Adverse Effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOutpatient Clinics, Hospitalen_US
dc.subject.meshPhysician's Practice Patternsen_US
dc.subject.meshPotassium - Blooden_US
dc.titleUse of indapamide in hospital and community clinics and its effect on plasma potassium in Chinese patientsen_US
dc.typeArticleen_US
dc.identifier.emailChan, WH:waichan@hku.hken_US
dc.identifier.authorityChan, WH=rp00667en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1046/j.1365-2710.1998.00162.xen_US
dc.identifier.pmid9867313-
dc.identifier.scopuseid_2-s2.0-0031723143en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031723143&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume23en_US
dc.identifier.issue4en_US
dc.identifier.spage295en_US
dc.identifier.epage302en_US
dc.identifier.isiWOS:000077466600006-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridChang, S=7405603139en_US
dc.identifier.scopusauthoridChan, WH=13310083000en_US
dc.identifier.scopusauthoridKong, Y=55216103900en_US
dc.identifier.scopusauthoridChan, GMC=37044630400en_US
dc.identifier.scopusauthoridRaymond, K=7102369968en_US
dc.identifier.scopusauthoridLee, A=7405631431en_US
dc.identifier.scopusauthoridLee, SC=7601413117en_US
dc.identifier.scopusauthoridCritchley, JAJH=7102824658en_US
dc.identifier.scopusauthoridChan, JCN=24490666900en_US

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