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Article: Appearance of β-adrenergic response of adenylate cyclase during the induction of differentiation in cell cultures

TitleAppearance of β-adrenergic response of adenylate cyclase during the induction of differentiation in cell cultures
Authors
Issue Date1979
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yexcr
Citation
Experimental Cell Research, 1979, v. 122 n. 2, p. 399-402 How to Cite?
AbstractChemical inducers of differentiation, such as dimethylsulfoxide, N-methylacetamide and sodium butyrate, induce various kinds of differentiated characteristics in tumor cell lines as shown by numerous studies. In this study we showed that one common property of this group of chemicals is their ability to induce β-adrenergic response of adenylate cyclase in cell cultures, including Friend erythroleukemic cells, HeLa cells and rat fetal hepatocytes. This induction appears to be an early event in the differentiation, since it precedes the appearance of other differentiated characteristics, such as hemoglobin synthesis in erythroleukemic cells. This induced hormone response may contribute to the regulation of subsequent steps of differentiation.
Persistent Identifierhttp://hdl.handle.net/10722/167446
ISSN
2015 Impact Factor: 3.378
2015 SCImago Journal Rankings: 1.900
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLin, CSen_US
dc.contributor.authorLin, MCen_US
dc.date.accessioned2012-10-08T03:07:05Z-
dc.date.available2012-10-08T03:07:05Z-
dc.date.issued1979en_US
dc.identifier.citationExperimental Cell Research, 1979, v. 122 n. 2, p. 399-402en_US
dc.identifier.issn0014-4827en_US
dc.identifier.urihttp://hdl.handle.net/10722/167446-
dc.description.abstractChemical inducers of differentiation, such as dimethylsulfoxide, N-methylacetamide and sodium butyrate, induce various kinds of differentiated characteristics in tumor cell lines as shown by numerous studies. In this study we showed that one common property of this group of chemicals is their ability to induce β-adrenergic response of adenylate cyclase in cell cultures, including Friend erythroleukemic cells, HeLa cells and rat fetal hepatocytes. This induction appears to be an early event in the differentiation, since it precedes the appearance of other differentiated characteristics, such as hemoglobin synthesis in erythroleukemic cells. This induced hormone response may contribute to the regulation of subsequent steps of differentiation.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yexcren_US
dc.relation.ispartofExperimental Cell Researchen_US
dc.subject.meshAcetamides - Pharmacologyen_US
dc.subject.meshAdenylate Cyclase - Metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshButyrates - Pharmacologyen_US
dc.subject.meshCell Differentiation - Drug Effectsen_US
dc.subject.meshCell Lineen_US
dc.subject.meshDimethyl Sulfoxide - Pharmacologyen_US
dc.subject.meshEnzyme Activation - Drug Effectsen_US
dc.subject.meshFollicle Stimulating Hormone - Biosynthesisen_US
dc.subject.meshFriend Murine Leukemia Virusen_US
dc.subject.meshHela Cellsen_US
dc.subject.meshHemoglobins - Biosynthesisen_US
dc.subject.meshHumansen_US
dc.subject.meshIsoproterenol - Pharmacologyen_US
dc.subject.meshLeukemia, Experimentalen_US
dc.subject.meshLiver - Embryologyen_US
dc.subject.meshMiceen_US
dc.subject.meshRatsen_US
dc.titleAppearance of β-adrenergic response of adenylate cyclase during the induction of differentiation in cell culturesen_US
dc.typeArticleen_US
dc.identifier.emailLin, MC:mcllin@hkucc.hku.hken_US
dc.identifier.authorityLin, MC=rp00746en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0014-4827(79)90318-5-
dc.identifier.pmid510408-
dc.identifier.scopuseid_2-s2.0-0018598654en_US
dc.identifier.volume122en_US
dc.identifier.issue2en_US
dc.identifier.spage399en_US
dc.identifier.epage402en_US
dc.identifier.isiWOS:A1979HQ77300019-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLin, CS=24540146100en_US
dc.identifier.scopusauthoridLin, MC=7404816359en_US

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