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Article: The role of adenine and guanine nucleotides in the activity and response of adenylate cyclase systems to hormones: evidence for multi site transition states

TitleThe role of adenine and guanine nucleotides in the activity and response of adenylate cyclase systems to hormones: evidence for multi site transition states
Authors
Issue Date1974
Citation
Acta Endocrinologica, Supplement, 1974, v. 77 Sup 191, p. 11-37 How to Cite?
AbstractEvidence is presented that the glucagon sensitive adenylate cyclase system in rat hepatic plasma membranes has the characteristics of an allosteric regulatory enzyme. Based primarily on kinetic considerations, the studies indicate that the activity of the enzyme is controlled by hormone, guanine nucleotides, and by the protonated species of substrate (HATP 3-), each ligand interacting selectively with sites termed receptor or discriminator, nucleotide regulatory site, and active site, respectively. Evidence is also presented that hormonal activation of adenylate cyclase systems in eucaryotic cells has characteristics in common with the glucagon sensitive hepatic system.
Persistent Identifierhttp://hdl.handle.net/10722/167430
ISSN

 

DC FieldValueLanguage
dc.contributor.authorRodbell, Men_US
dc.contributor.authorLin, MCen_US
dc.contributor.authorSalomon, Yen_US
dc.date.accessioned2012-10-08T03:06:51Z-
dc.date.available2012-10-08T03:06:51Z-
dc.date.issued1974en_US
dc.identifier.citationActa Endocrinologica, Supplement, 1974, v. 77 Sup 191, p. 11-37en_US
dc.identifier.issn0300-9750en_US
dc.identifier.urihttp://hdl.handle.net/10722/167430-
dc.description.abstractEvidence is presented that the glucagon sensitive adenylate cyclase system in rat hepatic plasma membranes has the characteristics of an allosteric regulatory enzyme. Based primarily on kinetic considerations, the studies indicate that the activity of the enzyme is controlled by hormone, guanine nucleotides, and by the protonated species of substrate (HATP 3-), each ligand interacting selectively with sites termed receptor or discriminator, nucleotide regulatory site, and active site, respectively. Evidence is also presented that hormonal activation of adenylate cyclase systems in eucaryotic cells has characteristics in common with the glucagon sensitive hepatic system.en_US
dc.languageengen_US
dc.relation.ispartofActa Endocrinologica, Supplementen_US
dc.titleThe role of adenine and guanine nucleotides in the activity and response of adenylate cyclase systems to hormones: evidence for multi site transition statesen_US
dc.typeArticleen_US
dc.identifier.emailLin, MC:mcllin@hkucc.hku.hken_US
dc.identifier.authorityLin, MC=rp00746en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-0016217293en_US
dc.identifier.volume77en_US
dc.identifier.issueSup 191en_US
dc.identifier.spage11en_US
dc.identifier.epage37en_US
dc.identifier.scopusauthoridRodbell, M=7006658086en_US
dc.identifier.scopusauthoridLin, MC=7404816359en_US
dc.identifier.scopusauthoridSalomon, Y=7006956498en_US

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