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Article: Microphthalmos associated with Dartmouth combination chemotherapy in pregnancy: A case report

TitleMicrophthalmos associated with Dartmouth combination chemotherapy in pregnancy: A case report
Authors
Issue Date2007
PublisherJournal of Reproductive Medicine, Inc. The Journal's web site is located at http://www.reproductivemedicine.com
Citation
Journal Of Reproductive Medicine For The Obstetrician And Gynecologist, 2007, v. 52 n. 6, p. 575-576 How to Cite?
AbstractBACKGROUND: Use of Dartmouth combination chemotherapy in pregnancy is scarcely reported, with only 1 report of its use in the late second and third trimesters and no report of its use in the first trimester. CASE: This is the first reported case in which the Dartmouth combination chemotherapy regimen was inadvertently used in a pregnant woman during the first and second trimesters for treatment of metastatic melanoma. The infant was found to have isolated microphthalmos and severe hypermetropia at 1 year of age. CONCLUSION: Although a causal relationship cannot be established from a single case, this report does provide useful information to discourage the use of this chemotherapy regimen in the first trimester, which is the critical period for organogenesis. © Journal of Reproductive Medicine®, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/167088
ISSN
2015 Impact Factor: 0.84
2015 SCImago Journal Rankings: 0.388
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, RHWen_US
dc.contributor.authorWing, HTen_US
dc.contributor.authorPak, CNen_US
dc.contributor.authorMok, TSKen_US
dc.contributor.authorTam, Ben_US
dc.contributor.authorTze, KLen_US
dc.date.accessioned2012-09-28T04:03:37Z-
dc.date.available2012-09-28T04:03:37Z-
dc.date.issued2007en_US
dc.identifier.citationJournal Of Reproductive Medicine For The Obstetrician And Gynecologist, 2007, v. 52 n. 6, p. 575-576en_US
dc.identifier.issn0024-7758en_US
dc.identifier.urihttp://hdl.handle.net/10722/167088-
dc.description.abstractBACKGROUND: Use of Dartmouth combination chemotherapy in pregnancy is scarcely reported, with only 1 report of its use in the late second and third trimesters and no report of its use in the first trimester. CASE: This is the first reported case in which the Dartmouth combination chemotherapy regimen was inadvertently used in a pregnant woman during the first and second trimesters for treatment of metastatic melanoma. The infant was found to have isolated microphthalmos and severe hypermetropia at 1 year of age. CONCLUSION: Although a causal relationship cannot be established from a single case, this report does provide useful information to discourage the use of this chemotherapy regimen in the first trimester, which is the critical period for organogenesis. © Journal of Reproductive Medicine®, Inc.en_US
dc.languageengen_US
dc.publisherJournal of Reproductive Medicine, Inc. The Journal's web site is located at http://www.reproductivemedicine.comen_US
dc.relation.ispartofJournal of Reproductive Medicine for the Obstetrician and Gynecologisten_US
dc.subject.meshAdulten_US
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols - Adverse Effectsen_US
dc.subject.meshCarmustine - Adverse Effectsen_US
dc.subject.meshCisplatin - Adverse Effectsen_US
dc.subject.meshDacarbazine - Adverse Effectsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshLiver Neoplasms - Drug Therapy - Secondaryen_US
dc.subject.meshMaleen_US
dc.subject.meshMelanoma - Drug Therapy - Secondaryen_US
dc.subject.meshMicrophthalmos - Chemically Induceden_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy Complications, Neoplastic - Drug Therapyen_US
dc.subject.meshPregnancy Trimester, First - Drug Effectsen_US
dc.subject.meshPregnancy Trimester, Second - Drug Effectsen_US
dc.subject.meshSkin Neoplasms - Drug Therapy - Pathologyen_US
dc.subject.meshTamoxifen - Adverse Effectsen_US
dc.titleMicrophthalmos associated with Dartmouth combination chemotherapy in pregnancy: A case reporten_US
dc.typeArticleen_US
dc.identifier.emailLi, RHW: raymondli@hku.hken_US
dc.identifier.authorityLi, RHW=rp01649en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid17694989-
dc.identifier.scopuseid_2-s2.0-34250793904en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34250793904&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume52en_US
dc.identifier.issue6en_US
dc.identifier.spage575en_US
dc.identifier.epage576en_US
dc.identifier.isiWOS:000247354600029-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLi, RHW=7404724295en_US
dc.identifier.scopusauthoridWing, HT=8564517100en_US
dc.identifier.scopusauthoridPak, CN=12345238900en_US
dc.identifier.scopusauthoridMok, TSK=7006561460en_US
dc.identifier.scopusauthoridTam, B=35973288900en_US
dc.identifier.scopusauthoridTze, KL=6507251018en_US

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