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Article: Theoretical quality assessment of myocardial elastography with in vivo validation

TitleTheoretical quality assessment of myocardial elastography with in vivo validation
Authors
Issue Date2007
Citation
Ieee Transactions On Ultrasonics, Ferroelectrics, And Frequency Control, 2007, v. 54 n. 11, p. 2233-2245 How to Cite?
AbstractMyocardial elastography (ME), a radio frequency (RF)-based speckle tracking technique with onedimensional (1-D) cross correlation and novel recorrelation methods in a 2-D search was proposed to estimate and fully image 2-D transmural deformation field and to detect abnormal cardiac function. A theoretical framework was first developed in order to evaluate the performance of 2-D myocardial elastography based on a previously developed 3D finite-element model of the canine left ventricle. A normal (control) and an ischemic (left-circumflex, LCx) model, which more completely represented myocardial deformation than a kinematic model, were considered. A 2-D convolutional image formation model was first used to generate RF signals for quality assessment of ME in the normal and ischemic cases. A 3-D image formation model was further developed to investigate the effect of the out-of-plane motion on the 2-D, in-plane motion estimation. Both orthogonal, in-plane displacement components (i.e., lateral and axial) between consecutive RF frames were iteratively estimated. All the estimated incremental 2-D displacements from enddiastole (ED) to end-systole (ES) were then accumulated to acquire the cumulative 2-D displacements, which were further used to calculate the cumulative 2-D systolic finite strains. Furthermore, the cumulative systolic radial and circumferential strains, which were angle- and frame-rate independent, were obtained from the 2-D finite-strain components and imaged in full view to detect the ischemic region. We also explored the theoretical understanding of the limitations of our technique for the accurate depiction of disease and validated it in vivo against tagged magnetic resonance imaging (tMRI) in the case of a normal human myocardium in a 2-D short-axis (SA) echocardiographic view. The theoretical framework succeeded in demonstrating that the 2-D myocardial elastography technique was a reliable tool for the complete estimation and depiction of the in-plane myocardial deformation field as well as for accurate identification of pathological mechanical function using established finite-element, left-ventricular canine models. In a preliminary study, the 2-D myocardial elastography was shown capable of imaging myocardial deformation comparable to equivalent tMRI estimates in a clinical setting. © 2007 IEEE.
Persistent Identifierhttp://hdl.handle.net/10722/167055
ISSN
2015 Impact Factor: 2.287
2015 SCImago Journal Rankings: 0.910
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLee, WNen_US
dc.contributor.authorIngrassia, CMen_US
dc.contributor.authorFungKeeFung, SDen_US
dc.contributor.authorCosta, KDen_US
dc.contributor.authorHolmes, JWen_US
dc.contributor.authorKonofagou, EEen_US
dc.date.accessioned2012-09-28T04:02:24Z-
dc.date.available2012-09-28T04:02:24Z-
dc.date.issued2007en_US
dc.identifier.citationIeee Transactions On Ultrasonics, Ferroelectrics, And Frequency Control, 2007, v. 54 n. 11, p. 2233-2245en_US
dc.identifier.issn0885-3010en_US
dc.identifier.urihttp://hdl.handle.net/10722/167055-
dc.description.abstractMyocardial elastography (ME), a radio frequency (RF)-based speckle tracking technique with onedimensional (1-D) cross correlation and novel recorrelation methods in a 2-D search was proposed to estimate and fully image 2-D transmural deformation field and to detect abnormal cardiac function. A theoretical framework was first developed in order to evaluate the performance of 2-D myocardial elastography based on a previously developed 3D finite-element model of the canine left ventricle. A normal (control) and an ischemic (left-circumflex, LCx) model, which more completely represented myocardial deformation than a kinematic model, were considered. A 2-D convolutional image formation model was first used to generate RF signals for quality assessment of ME in the normal and ischemic cases. A 3-D image formation model was further developed to investigate the effect of the out-of-plane motion on the 2-D, in-plane motion estimation. Both orthogonal, in-plane displacement components (i.e., lateral and axial) between consecutive RF frames were iteratively estimated. All the estimated incremental 2-D displacements from enddiastole (ED) to end-systole (ES) were then accumulated to acquire the cumulative 2-D displacements, which were further used to calculate the cumulative 2-D systolic finite strains. Furthermore, the cumulative systolic radial and circumferential strains, which were angle- and frame-rate independent, were obtained from the 2-D finite-strain components and imaged in full view to detect the ischemic region. We also explored the theoretical understanding of the limitations of our technique for the accurate depiction of disease and validated it in vivo against tagged magnetic resonance imaging (tMRI) in the case of a normal human myocardium in a 2-D short-axis (SA) echocardiographic view. The theoretical framework succeeded in demonstrating that the 2-D myocardial elastography technique was a reliable tool for the complete estimation and depiction of the in-plane myocardial deformation field as well as for accurate identification of pathological mechanical function using established finite-element, left-ventricular canine models. In a preliminary study, the 2-D myocardial elastography was shown capable of imaging myocardial deformation comparable to equivalent tMRI estimates in a clinical setting. © 2007 IEEE.en_US
dc.languageengen_US
dc.relation.ispartofIEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Controlen_US
dc.titleTheoretical quality assessment of myocardial elastography with in vivo validationen_US
dc.typeArticleen_US
dc.identifier.emailLee, WN: wnlee@hku.hken_US
dc.identifier.authorityLee, WN=rp01663en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1109/TUFFC.2007.528en_US
dc.identifier.pmid18051158-
dc.identifier.scopuseid_2-s2.0-34547373930en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34547373930&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume54en_US
dc.identifier.issue11en_US
dc.identifier.spage2233en_US
dc.identifier.epage2245en_US
dc.identifier.isiWOS:000250789400003-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLee, WN=22634980600en_US
dc.identifier.scopusauthoridIngrassia, CM=8616893200en_US
dc.identifier.scopusauthoridFungKeeFung, SD=14919178600en_US
dc.identifier.scopusauthoridCosta, KD=26638724700en_US
dc.identifier.scopusauthoridHolmes, JW=7403240348en_US
dc.identifier.scopusauthoridKonofagou, EE=7005877325en_US

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