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Article: Avian influenza (H5N1) virus of clade 2.3.2 in domestic poultry in India

TitleAvian influenza (H5N1) virus of clade 2.3.2 in domestic poultry in India
Authors
Issue Date2012
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
PLoS One, 2012, v. 7 n. 2, article no. e31844 How to Cite?
AbstractSouth Asia has experienced regular outbreaks of H5N1 avian influenza virus since its first detection in India and Pakistan in February, 2006. Till 2009, the outbreaks in this region were due to clade 2.2 H5N1 virus. In 2010, Nepal reported the first outbreak of clade 2.3.2 virus in South Asia. In February 2011, two outbreaks of H5N1 virus were reported in the State of Tripura in India. The antigenic and genetic analyses of seven H5N1 viruses isolated during these outbreaks were carried out. Antigenic analysis confirmed 64 to 256-fold reduction in cross reactivity compared with clade 2.2 viruses. The intravenous pathogenicity index of the isolates ranged from 2.80-2.95 indicating high pathogenicity to chickens. Sequencing of all the eight gene-segments of seven H5N1 viruses isolated in these outbreaks was carried out. The predicted amino acid sequence analysis revealed high pathogenicity to chickens and susceptibility to the antivirals, amantadine and oseltamivir. Phylogenetic analyses indicated that these viruses belong to clade 2.3.2.1 and were distinct to the clade 2.3.2.1 viruses isolated in Nepal. Identification of new clade 2.3.2 H5N1 viruses in South Asia is reminiscent of the introduction of clade 2.2 viruses in this region in 2006/7. It is now important to monitor whether the clade 2.3.2.1 is replacing clade 2.2 in this region or co-circulating with it. Continued co-circulation of various subclades of the H5N1 virus which are more adapted to land based poultry in a highly populated region such as South Asia increases the risk of evolution of pandemic H5N1 strains.
Persistent Identifierhttp://hdl.handle.net/10722/166787
ISSN
2014 Impact Factor: 3.234
2014 SCImago Journal Rankings: 1.300
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNagarajan, Sen_US
dc.contributor.authorTosh, Cen_US
dc.contributor.authorSmith, DKen_US
dc.contributor.authorPeiris, JSMen_US
dc.contributor.authorMurugkar, HVen_US
dc.contributor.authorSridevi, Ren_US
dc.contributor.authorKumar, Men_US
dc.contributor.authorKatare, Men_US
dc.contributor.authorJain, Ren_US
dc.contributor.authorSyed, Zen_US
dc.contributor.authorBehera, Pen_US
dc.contributor.authorCheung, CLen_US
dc.contributor.authorKhandia, Ren_US
dc.contributor.authorTripathi, Sen_US
dc.contributor.authorGuan, Yen_US
dc.contributor.authorDubey, SCen_US
dc.date.accessioned2012-09-20T08:48:09Z-
dc.date.available2012-09-20T08:48:09Z-
dc.date.issued2012en_US
dc.identifier.citationPLoS One, 2012, v. 7 n. 2, article no. e31844en_US
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/10722/166787-
dc.description.abstractSouth Asia has experienced regular outbreaks of H5N1 avian influenza virus since its first detection in India and Pakistan in February, 2006. Till 2009, the outbreaks in this region were due to clade 2.2 H5N1 virus. In 2010, Nepal reported the first outbreak of clade 2.3.2 virus in South Asia. In February 2011, two outbreaks of H5N1 virus were reported in the State of Tripura in India. The antigenic and genetic analyses of seven H5N1 viruses isolated during these outbreaks were carried out. Antigenic analysis confirmed 64 to 256-fold reduction in cross reactivity compared with clade 2.2 viruses. The intravenous pathogenicity index of the isolates ranged from 2.80-2.95 indicating high pathogenicity to chickens. Sequencing of all the eight gene-segments of seven H5N1 viruses isolated in these outbreaks was carried out. The predicted amino acid sequence analysis revealed high pathogenicity to chickens and susceptibility to the antivirals, amantadine and oseltamivir. Phylogenetic analyses indicated that these viruses belong to clade 2.3.2.1 and were distinct to the clade 2.3.2.1 viruses isolated in Nepal. Identification of new clade 2.3.2 H5N1 viruses in South Asia is reminiscent of the introduction of clade 2.2 viruses in this region in 2006/7. It is now important to monitor whether the clade 2.3.2.1 is replacing clade 2.2 in this region or co-circulating with it. Continued co-circulation of various subclades of the H5N1 virus which are more adapted to land based poultry in a highly populated region such as South Asia increases the risk of evolution of pandemic H5N1 strains.-
dc.languageengen_US
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action-
dc.relation.ispartofPLoS Oneen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAntigens, Viral - genetics - immunology-
dc.subject.meshHemagglutinin Glycoproteins, Influenza Virus - genetics-
dc.subject.meshInfluenza A Virus, H5N1 Subtype - classification - genetics - immunology-
dc.subject.meshInfluenza in Birds - immunology - virology-
dc.subject.meshPoultry - virology-
dc.titleAvian influenza (H5N1) virus of clade 2.3.2 in domestic poultry in Indiaen_US
dc.typeArticleen_US
dc.identifier.emailSmith, DK: dsmith@hku.hken_US
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_US
dc.identifier.emailCheung, CL: cheungcl@hkucc.hku.hken_US
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_US
dc.identifier.authorityPeiris, JSM=rp00410en_US
dc.identifier.authorityGuan, Y=rp00397en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0031844-
dc.identifier.pmid22363750-
dc.identifier.pmcidPMC3282738-
dc.identifier.scopuseid_2-s2.0-84857438531-
dc.identifier.hkuros211104en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84857438531&selection=ref&src=s&origin=recordpage-
dc.identifier.volume7en_US
dc.identifier.issue2, article no. e31844-
dc.identifier.isiWOS:000302871500094-
dc.publisher.placeUnited States-
dc.identifier.scopusauthoridNagarajan, S=21739930700-
dc.identifier.scopusauthoridTosh, C=7003836762-
dc.identifier.scopusauthoridSmith, DK=55019162500-
dc.identifier.scopusauthoridPeiris, JSM=7005486823-
dc.identifier.scopusauthoridMurugkar, HV=36943216300-
dc.identifier.scopusauthoridSridevi, R=36121558900-
dc.identifier.scopusauthoridKumar, M=35368554400-
dc.identifier.scopusauthoridKatare, M=36463699600-
dc.identifier.scopusauthoridJain, R=7403423571-
dc.identifier.scopusauthoridSyed, Z=36549487100-
dc.identifier.scopusauthoridBehera, P=7004283513-
dc.identifier.scopusauthoridCheung, CL=34975244700-
dc.identifier.scopusauthoridKhandia, R=14054295400-
dc.identifier.scopusauthoridTripathi, S=47461839000-
dc.identifier.scopusauthoridGuan, Y=7202924055-
dc.identifier.scopusauthoridDubey, SC=7102521173-

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