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Book Chapter: Mortalin-p53 interaction as a target for liver cancer therapy

TitleMortalin-p53 interaction as a target for liver cancer therapy
Authors
Issue Date2012
PublisherSpringer
Citation
Mortalin-p53 interaction as a target for liver cancer therapy. In Kaul, SC & Wadhwa, R (Eds.), Mortalin Biology: Life, Stress and Death, p. 267-278. Dordrecht ; New York: Springer, 2012 How to Cite?
AbstractMortalin is a member of Hsp70 family that exhibits a tight correlation with carcinogenesis. It has been shown to inactivate tumor suppressor protein p53. The present chapter reviews the history and presents information of mortalin, p53 and how their interaction contributes to carcinogenesis. It is demonstrated that mortalin-p53 interaction that is a cancer-driving event depends on the stress state of cells. The small molecules and short peptides that were able to block this interaction could induce apoptosis in cancer cells that harbour mutant p53 suggesting that mortalin-p53 is a good target for cancer therapy. Understanding of the molecular regulation of mortalin-p53 interaction and their role in highly malignant cells will help designing better strategies for cancer treatment.
Persistent Identifierhttp://hdl.handle.net/10722/166596
ISBN

 

DC FieldValueLanguage
dc.contributor.authorLu, WJen_US
dc.contributor.authorLee, NPYen_US
dc.contributor.authorWadhwa, Ren_US
dc.contributor.authorLuk, JMCen_US
dc.date.accessioned2012-09-20T08:41:56Z-
dc.date.available2012-09-20T08:41:56Z-
dc.date.issued2012en_US
dc.identifier.citationMortalin-p53 interaction as a target for liver cancer therapy. In Kaul, SC & Wadhwa, R (Eds.), Mortalin Biology: Life, Stress and Death, p. 267-278. Dordrecht ; New York: Springer, 2012en_US
dc.identifier.isbn9789400730267en_US
dc.identifier.urihttp://hdl.handle.net/10722/166596-
dc.description.abstractMortalin is a member of Hsp70 family that exhibits a tight correlation with carcinogenesis. It has been shown to inactivate tumor suppressor protein p53. The present chapter reviews the history and presents information of mortalin, p53 and how their interaction contributes to carcinogenesis. It is demonstrated that mortalin-p53 interaction that is a cancer-driving event depends on the stress state of cells. The small molecules and short peptides that were able to block this interaction could induce apoptosis in cancer cells that harbour mutant p53 suggesting that mortalin-p53 is a good target for cancer therapy. Understanding of the molecular regulation of mortalin-p53 interaction and their role in highly malignant cells will help designing better strategies for cancer treatment.-
dc.languageengen_US
dc.publisherSpringeren_US
dc.relation.ispartofMortalin Biology: Life, Stress and Deathen_US
dc.titleMortalin-p53 interaction as a target for liver cancer therapyen_US
dc.typeBook_Chapteren_US
dc.identifier.emailLee, NPY: nikkilee@hku.hken_US
dc.identifier.emailLuk, JMC: jmluk@hku.hken_US
dc.identifier.authorityLee, NPY=rp00263en_US
dc.identifier.authorityLuk, JMC=rp00349en_US
dc.identifier.doi10.1007/978-94-007-3027-4_17-
dc.identifier.hkuros211301en_US
dc.identifier.spage267en_US
dc.identifier.epage278en_US
dc.publisher.placeDordrecht ; New York-

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