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Article: Hepatoprotective effect and its possible mechanism of Coptidis rhizoma aqueous extract on carbon tetrachloride-induced chronic liver hepatotoxicity in rats

TitleHepatoprotective effect and its possible mechanism of Coptidis rhizoma aqueous extract on carbon tetrachloride-induced chronic liver hepatotoxicity in rats
Authors
Issue Date2011
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jethpharm
Citation
Journal of Ethnopharmacology, 2011, v. 138 n. 3, p. 683-690 How to Cite?
AbstractEthnopharmacological relevance: Coptidis rhizoma is traditionally used for heat-clearing and toxic-scavenging and it belongs to liver meridian in Chinese medicine practice. Clinically, Coptidis rhizoma can be used for hepatic and biliary disorders, yet details in the therapies of liver diseases and underlying mechanism(s) remain unclear. Our previous study demonstrated that Coptidis rhizoma aqueous extract (CRAE) against CCl 4-induced acute liver damage was related to antioxidant property. In the present study, the protection of CRAE on chronic liver damage induced by carbon tetrachloride (CCl 4) in rats and its related mechanism were explored. Materials and methods: The CCl 4-induced chronic liver damage model was established, and CRAE's protective effect was examined. Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activity, serum and liver superoxide dismutase (SOD) activity were then measured. The histological changes were observed under microscopy and then computed in numerical score. The normal or damaged cells were isolated and related signaling pathway was evaluated. Result: Serum AST and ALT activities were significantly decreased in rats treated with different doses of CRAE, indicating its protective effect against CCl 4-induced chronic liver damage. Observation on serum SOD activity revealed that CRAE might act as an anti-oxidant agent against CCl 4-induced chronic oxide stress. Histological study supported these observations. Erk1/2 inhibition may take part into CRAE's effect on preventing hepatocyte from apoptosis when exposed to oxidative stress. Conclusion: CRAE showed protective effect against CCl 4-induced chronic liver damage in rats and its potential as an agent in the treatment of chronic liver diseases by protecting hepatocyte from injury. © 2011 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/166186
ISSN
2015 Impact Factor: 3.055
2015 SCImago Journal Rankings: 1.156
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFeng, Yen_HK
dc.contributor.authorWang, Nen_HK
dc.contributor.authorYe, Xen_HK
dc.contributor.authorLi, Hen_HK
dc.contributor.authorFeng, YGen_HK
dc.contributor.authorCheung, Fen_HK
dc.contributor.authorNagamatsu, Ten_HK
dc.date.accessioned2012-09-20T08:30:00Z-
dc.date.available2012-09-20T08:30:00Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal of Ethnopharmacology, 2011, v. 138 n. 3, p. 683-690en_US
dc.identifier.issn0378-8741en_HK
dc.identifier.urihttp://hdl.handle.net/10722/166186-
dc.description.abstractEthnopharmacological relevance: Coptidis rhizoma is traditionally used for heat-clearing and toxic-scavenging and it belongs to liver meridian in Chinese medicine practice. Clinically, Coptidis rhizoma can be used for hepatic and biliary disorders, yet details in the therapies of liver diseases and underlying mechanism(s) remain unclear. Our previous study demonstrated that Coptidis rhizoma aqueous extract (CRAE) against CCl 4-induced acute liver damage was related to antioxidant property. In the present study, the protection of CRAE on chronic liver damage induced by carbon tetrachloride (CCl 4) in rats and its related mechanism were explored. Materials and methods: The CCl 4-induced chronic liver damage model was established, and CRAE's protective effect was examined. Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activity, serum and liver superoxide dismutase (SOD) activity were then measured. The histological changes were observed under microscopy and then computed in numerical score. The normal or damaged cells were isolated and related signaling pathway was evaluated. Result: Serum AST and ALT activities were significantly decreased in rats treated with different doses of CRAE, indicating its protective effect against CCl 4-induced chronic liver damage. Observation on serum SOD activity revealed that CRAE might act as an anti-oxidant agent against CCl 4-induced chronic oxide stress. Histological study supported these observations. Erk1/2 inhibition may take part into CRAE's effect on preventing hepatocyte from apoptosis when exposed to oxidative stress. Conclusion: CRAE showed protective effect against CCl 4-induced chronic liver damage in rats and its potential as an agent in the treatment of chronic liver diseases by protecting hepatocyte from injury. © 2011 Elsevier Ireland Ltd. All rights reserved.en_HK
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jethpharmen_HK
dc.relation.ispartofJournal of Ethnopharmacologyen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshRatsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMAP Kinase Signaling System - drug effectsen_HK
dc.subject.meshHepatocytes - drug effects - metabolismen_HK
dc.subject.meshDrugs, Chinese Herbal - analysis - therapeutic useen_HK
dc.subject.meshDrug-Induced Liver Injury - blood - drug therapy - pathologyen_HK
dc.subject.meshDNA Fragmentation - drug effectsen_HK
dc.subject.meshCaspase 3 - metabolismen_HK
dc.subject.meshCarbon Tetrachlorideen_HK
dc.subject.meshAspartate Aminotransferases - blooden_HK
dc.subject.meshApoptosis - drug effectsen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAlanine Transaminase - blooden_HK
dc.titleHepatoprotective effect and its possible mechanism of Coptidis rhizoma aqueous extract on carbon tetrachloride-induced chronic liver hepatotoxicity in ratsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0378-8741&volume=138&issue=3&spage=683&epage=690&date=2011&atitle=Hepatoprotective+effect+and+its+possible+mechanism+of+Coptidis+rhizoma+aqueous+extract+on+carbon+tetrachloride-induced+chronic+liver+hepatotoxicity+in+ratsen_US
dc.identifier.emailFeng, Y: yfeng@hku.hken_HK
dc.identifier.emailWang, N: ckwang@hku.hk-
dc.identifier.emailYe, X: xiujuany@hku.hk-
dc.identifier.emailCheung, F: h0180012@HKUSUC.hku.hk-
dc.identifier.emailNagamatsu, T: nagamats@ccmfs.meijo-u.ac.jp-
dc.identifier.authorityFeng, Y=rp00466en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jep.2011.09.032en_HK
dc.identifier.pmid21963555-
dc.identifier.scopuseid_2-s2.0-82455210880en_HK
dc.identifier.hkuros208639en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-82455210880&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume138en_HK
dc.identifier.issue3en_HK
dc.identifier.spage683en_HK
dc.identifier.epage690en_HK
dc.identifier.eissn1872-7573-
dc.identifier.isiWOS:000298897800006-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridNagamatsu, T=7006510058en_HK
dc.identifier.scopusauthoridCheung, F=54796436400en_HK
dc.identifier.scopusauthoridFeng, Y=36983738700en_HK
dc.identifier.scopusauthoridLi, H=54796615400en_HK
dc.identifier.scopusauthoridYe, X=35277763000en_HK
dc.identifier.scopusauthoridWang, N=35072317700en_HK
dc.identifier.scopusauthoridFeng, Y=24467969600en_HK
dc.identifier.citeulike9824250-

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