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Conference Paper: Interleukin-1 beta gene polymorphism associated with radiographic knee osteoarthritis in Chinese

TitleInterleukin-1 beta gene polymorphism associated with radiographic knee osteoarthritis in Chinese
Authors
Issue Date2011
PublisherSICOT 2011.
Citation
The 25th Triennial World Congress (SICOT 2011), Prague, Czech Republic, 6-9 September 2011. In Abstract Book of 25th Triennial World Congress, SICOT 2011 How to Cite?
AbstractRecently, the involvement of genetic factors for severe osteoarthritis (OA) has been widely reported. However, a lack of biomarkers that identify patients at risk complicates development of disease-modifying OA drugs. The purpose of this study was to identify polymorphisms at particular risk of osteoarthritis of the knee Chinese people. 481 participants were recruited. All control subjects were over 60 years. Severity of knee OA was evaluated by radiography. Cases (n = 300) were defined if Kellgren & Lawrence grade was 3-4, and controls (n = 181) were those in grade 0-1. Genotyping of these individuals were carried out by Sequenom. Interleukin-1 beta (IL1B) polymorphism was found to be associated with radiographic OA (ROA). Two SNPs (rs1143627 and rs16944) in high linkage disequilibrium (LD) upstream of the IL1B gene were found to be associated with ROA (Chi-square P-values = 0.009294 and 0.01012 respectively). Odds ratio (OR) for A allele of rs1143627 was 1.866, 95% confidence interval (95%CI) 0.2411 - 2.994. OR for G allele of rs16944 was 1.841, 95% CI 1.153 - 2.939. P-values for haplotype test for the SNPs were similar to single SNP test (0.009221), reflecting the high LD between the SNPs. Our results confirm the association of two SNPs in IL1B with ROA. An allele of rs1143627 and G allele of rs16944 were found to have significantly higher allele frequency in ROA cases than controls. The results indicate there is a possible role for IL1B played in the etiology of ROA.
DescriptionFree Papers: Research - Miscellaneous I: abstract no. 29209
Persistent Identifierhttp://hdl.handle.net/10722/165502

 

DC FieldValueLanguage
dc.contributor.authorYan, CHen_US
dc.contributor.authorQiu, Yen_US
dc.contributor.authorChiu, KYen_US
dc.contributor.authorNg, FYen_US
dc.date.accessioned2012-09-20T08:19:14Z-
dc.date.available2012-09-20T08:19:14Z-
dc.date.issued2011en_US
dc.identifier.citationThe 25th Triennial World Congress (SICOT 2011), Prague, Czech Republic, 6-9 September 2011. In Abstract Book of 25th Triennial World Congress, SICOT 2011en_US
dc.identifier.urihttp://hdl.handle.net/10722/165502-
dc.descriptionFree Papers: Research - Miscellaneous I: abstract no. 29209-
dc.description.abstractRecently, the involvement of genetic factors for severe osteoarthritis (OA) has been widely reported. However, a lack of biomarkers that identify patients at risk complicates development of disease-modifying OA drugs. The purpose of this study was to identify polymorphisms at particular risk of osteoarthritis of the knee Chinese people. 481 participants were recruited. All control subjects were over 60 years. Severity of knee OA was evaluated by radiography. Cases (n = 300) were defined if Kellgren & Lawrence grade was 3-4, and controls (n = 181) were those in grade 0-1. Genotyping of these individuals were carried out by Sequenom. Interleukin-1 beta (IL1B) polymorphism was found to be associated with radiographic OA (ROA). Two SNPs (rs1143627 and rs16944) in high linkage disequilibrium (LD) upstream of the IL1B gene were found to be associated with ROA (Chi-square P-values = 0.009294 and 0.01012 respectively). Odds ratio (OR) for A allele of rs1143627 was 1.866, 95% confidence interval (95%CI) 0.2411 - 2.994. OR for G allele of rs16944 was 1.841, 95% CI 1.153 - 2.939. P-values for haplotype test for the SNPs were similar to single SNP test (0.009221), reflecting the high LD between the SNPs. Our results confirm the association of two SNPs in IL1B with ROA. An allele of rs1143627 and G allele of rs16944 were found to have significantly higher allele frequency in ROA cases than controls. The results indicate there is a possible role for IL1B played in the etiology of ROA.-
dc.languageengen_US
dc.publisherSICOT 2011.-
dc.relation.ispartofAbstract Book of 25th Triennial World Congress, SICOT 2011en_US
dc.titleInterleukin-1 beta gene polymorphism associated with radiographic knee osteoarthritis in Chineseen_US
dc.typeConference_Paperen_US
dc.identifier.emailYan, CH: yanchoi@hku.hken_US
dc.identifier.emailChiu, KY: pkychiu@hkucc.hku.hken_US
dc.identifier.emailNg, FY: fyng@hkucc.hku.hken_US
dc.identifier.authorityYan, CH=rp00303en_US
dc.identifier.authorityChiu, KY=rp00379en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros208375en_US
dc.identifier.hkuros205315-
dc.customcontrol.immutablesml 130514-

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