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Conference Paper: Engineering micro-alignments of 2- and 3-D hESC-derived ventricular tissues to reproduce anisotropic properties of the native heart: an accurate arrhythmias model for cardiotoxicity screening

TitleEngineering micro-alignments of 2- and 3-D hESC-derived ventricular tissues to reproduce anisotropic properties of the native heart: an accurate arrhythmias model for cardiotoxicity screening
Authors
Issue Date2011
Citation
The 2011 Meeting of the Days of Molecular Medicine (DMM), Hong Kong, 10-12 November 2011. How to Cite?
AbstractIn the native heart, ventricular CMs are aligned in a highly organized structured manner such that the conduction of electrical signals is anisotropic for directional and coordinated contractions to effectively pump blood. In other words, electrical conduction is asymmetrical (i.e. anisotropy) with distinct transverse and longitudinal velocities. Unlike the native ventricle, clusters of hESC-CMs differentiated using either the EB formation or directed differentiation are random structures with NO obvious organization and anisotropy as we previously published. Using a microgroove technology, here we engineered organized 2- and 3-D hESC-derived ventricular strips, followed by high-resolution optical mapping recordings …
DescriptionDMM 2011 entitled: Re-engineering Regenerative Medicine
Poster Session - Heart Regeneration: no. 26
Persistent Identifierhttp://hdl.handle.net/10722/165469

 

DC FieldValueLanguage
dc.contributor.authorWang, EJen_US
dc.contributor.authorLieu, DKen_US
dc.contributor.authorKarakikes, Ien_US
dc.contributor.authorChen, Aen_US
dc.contributor.authorTurnbull, Ien_US
dc.contributor.authorKong, Men_US
dc.contributor.authorHajjar, Ren_US
dc.contributor.authorCosta, Ken_US
dc.contributor.authorKhine, Men_US
dc.contributor.authorLi, RAen_US
dc.date.accessioned2012-09-20T08:18:27Z-
dc.date.available2012-09-20T08:18:27Z-
dc.date.issued2011en_US
dc.identifier.citationThe 2011 Meeting of the Days of Molecular Medicine (DMM), Hong Kong, 10-12 November 2011.en_US
dc.identifier.urihttp://hdl.handle.net/10722/165469-
dc.descriptionDMM 2011 entitled: Re-engineering Regenerative Medicine-
dc.descriptionPoster Session - Heart Regeneration: no. 26-
dc.description.abstractIn the native heart, ventricular CMs are aligned in a highly organized structured manner such that the conduction of electrical signals is anisotropic for directional and coordinated contractions to effectively pump blood. In other words, electrical conduction is asymmetrical (i.e. anisotropy) with distinct transverse and longitudinal velocities. Unlike the native ventricle, clusters of hESC-CMs differentiated using either the EB formation or directed differentiation are random structures with NO obvious organization and anisotropy as we previously published. Using a microgroove technology, here we engineered organized 2- and 3-D hESC-derived ventricular strips, followed by high-resolution optical mapping recordings …-
dc.languageengen_US
dc.relation.ispartofDay of Molecular Medicine, DMM 2011en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleEngineering micro-alignments of 2- and 3-D hESC-derived ventricular tissues to reproduce anisotropic properties of the native heart: an accurate arrhythmias model for cardiotoxicity screeningen_US
dc.typeConference_Paperen_US
dc.identifier.emailKong, M: marcokong@hku.hken_US
dc.identifier.emailLi, RA: ronaldli@hkucc.hku.hken_US
dc.identifier.authorityKong, M=rp01563en_US
dc.identifier.authorityLi, RA=rp01352en_US
dc.description.naturepostprint-
dc.identifier.hkuros211228en_US

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