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Conference Paper: Sarco/Endoplasmic Reticulum Ca-ATPase (SERCA) pump is a more effective Calcium-handling mediator than the Sodium-Calcium Exchanger (NCX) in hESC-derived ventricular cardiomyocytes

TitleSarco/Endoplasmic Reticulum Ca-ATPase (SERCA) pump is a more effective Calcium-handling mediator than the Sodium-Calcium Exchanger (NCX) in hESC-derived ventricular cardiomyocytes
Authors
Issue Date2011
Citation
The 2011 Meeting of the Days of Molecular Medicine (DMM), Hong Kong, 10-12 November 2011. How to Cite?
AbstractVentricular (V) cardiomyocytes (CMs) are non-regenerative. Self-renewable pluripotent human embryonic stem cells (hESCs) can differentiate into CMs for cellbased therapies. We have previously shown that hESC-derived CMs display immature Ca-handling properties, with smaller transient amplitudes and slower upstroke and decay kinetics. These functional immaturities can be attributed to their proteomic differences in crucial Ca-handling proteins such as the complete absence of triadin, junctin, CSQ, phospholamban. Indeed, forced CSQ expression partially …
DescriptionDMM 2011 entitled: Re-engineering Regenerative Medicine
Poster Session - Heart Regeneration: no. 29
Persistent Identifierhttp://hdl.handle.net/10722/165468

 

DC FieldValueLanguage
dc.contributor.authorLi, Sen_US
dc.contributor.authorYeung, PHMen_US
dc.contributor.authorKong, Men_US
dc.contributor.authorLi, RAen_US
dc.date.accessioned2012-09-20T08:18:26Z-
dc.date.available2012-09-20T08:18:26Z-
dc.date.issued2011en_US
dc.identifier.citationThe 2011 Meeting of the Days of Molecular Medicine (DMM), Hong Kong, 10-12 November 2011.en_US
dc.identifier.urihttp://hdl.handle.net/10722/165468-
dc.descriptionDMM 2011 entitled: Re-engineering Regenerative Medicine-
dc.descriptionPoster Session - Heart Regeneration: no. 29-
dc.description.abstractVentricular (V) cardiomyocytes (CMs) are non-regenerative. Self-renewable pluripotent human embryonic stem cells (hESCs) can differentiate into CMs for cellbased therapies. We have previously shown that hESC-derived CMs display immature Ca-handling properties, with smaller transient amplitudes and slower upstroke and decay kinetics. These functional immaturities can be attributed to their proteomic differences in crucial Ca-handling proteins such as the complete absence of triadin, junctin, CSQ, phospholamban. Indeed, forced CSQ expression partially …-
dc.languageengen_US
dc.relation.ispartofDay of Molecular Medicine, DMM 2011en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleSarco/Endoplasmic Reticulum Ca-ATPase (SERCA) pump is a more effective Calcium-handling mediator than the Sodium-Calcium Exchanger (NCX) in hESC-derived ventricular cardiomyocytesen_US
dc.typeConference_Paperen_US
dc.identifier.emailKong, M: marcokong@hku.hken_US
dc.identifier.emailLi, RA: ronaldli@hkucc.hku.hken_US
dc.identifier.authorityKong, M=rp01563en_US
dc.identifier.authorityLi, RA=rp01352en_US
dc.description.naturepostprint-
dc.identifier.hkuros211227en_US

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