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Conference Paper: Sarco/Endoplasmic Reticulum Ca-ATPase (SERCA) pump is a more effective Calcium-handling mediator than the Sodium-Calcium Exchanger (NCX) in hESC-derived ventricular cardiomyocytes
| Title | Sarco/Endoplasmic Reticulum Ca-ATPase (SERCA) pump is a more effective Calcium-handling mediator than the Sodium-Calcium Exchanger (NCX) in hESC-derived ventricular cardiomyocytes |
|---|---|
| Authors | |
| Issue Date | 2011 |
| Citation | The 2011 Meeting of the Days of Molecular Medicine (DMM), Hong Kong, 10-12 November 2011. How to Cite? |
| Abstract | Ventricular (V) cardiomyocytes (CMs) are non-regenerative. Self-renewable pluripotent human embryonic stem cells (hESCs) can differentiate into CMs for cellbased therapies. We have previously shown that hESC-derived CMs display immature Ca-handling properties, with smaller transient amplitudes and slower upstroke and decay kinetics. These functional immaturities can be attributed to their proteomic differences in crucial Ca-handling proteins such as the complete absence of triadin, junctin, CSQ, phospholamban. Indeed, forced CSQ expression partially … |
| Description | DMM 2011 entitled: Re-engineering Regenerative Medicine Poster Session - Heart Regeneration: no. 29 |
| Persistent Identifier | http://hdl.handle.net/10722/165468 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Li, S | en_US |
| dc.contributor.author | Yeung, PHM | en_US |
| dc.contributor.author | Kong, M | en_US |
| dc.contributor.author | Li, RA | en_US |
| dc.date.accessioned | 2012-09-20T08:18:26Z | - |
| dc.date.available | 2012-09-20T08:18:26Z | - |
| dc.date.issued | 2011 | en_US |
| dc.identifier.citation | The 2011 Meeting of the Days of Molecular Medicine (DMM), Hong Kong, 10-12 November 2011. | en_US |
| dc.identifier.uri | http://hdl.handle.net/10722/165468 | - |
| dc.description | DMM 2011 entitled: Re-engineering Regenerative Medicine | - |
| dc.description | Poster Session - Heart Regeneration: no. 29 | - |
| dc.description.abstract | Ventricular (V) cardiomyocytes (CMs) are non-regenerative. Self-renewable pluripotent human embryonic stem cells (hESCs) can differentiate into CMs for cellbased therapies. We have previously shown that hESC-derived CMs display immature Ca-handling properties, with smaller transient amplitudes and slower upstroke and decay kinetics. These functional immaturities can be attributed to their proteomic differences in crucial Ca-handling proteins such as the complete absence of triadin, junctin, CSQ, phospholamban. Indeed, forced CSQ expression partially … | - |
| dc.language | eng | en_US |
| dc.relation.ispartof | Day of Molecular Medicine, DMM 2011 | en_US |
| dc.title | Sarco/Endoplasmic Reticulum Ca-ATPase (SERCA) pump is a more effective Calcium-handling mediator than the Sodium-Calcium Exchanger (NCX) in hESC-derived ventricular cardiomyocytes | en_US |
| dc.type | Conference_Paper | en_US |
| dc.identifier.email | Kong, M: marcokong@hku.hk | en_US |
| dc.identifier.email | Li, RA: ronaldli@hkucc.hku.hk | en_US |
| dc.identifier.authority | Kong, M=rp01563 | en_US |
| dc.identifier.authority | Li, RA=rp01352 | en_US |
| dc.description.nature | postprint | - |
| dc.identifier.hkuros | 211227 | en_US |