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Conference Paper: Therapeutic potential of pluripotent stem cell-derived mescenchymal stem cells in cardiovascular regeneration

TitleTherapeutic potential of pluripotent stem cell-derived mescenchymal stem cells in cardiovascular regeneration
Authors
Issue Date2011
PublisherHong Kong College of Cardiology. The Journal's web site is located at http://www.hkcchk.com/journals.php#3
Citation
The 15th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine (ICSM 2011), Hong Kong, China, 17 September 2011. In Journal of the Hong Kong College of Cardiology, 2011, v. 19 n. 2, p. 67, abstract no. PL5 How to Cite?
AbstractRecent experimental and clinical studies suggest that transplantation of bone marrow derived mesenchymal stem cells (BM-MSCs) is an attractive therapeutic option for ischemic cardiovascular diseases. However, there are several potential limitations of using BM derived-MSCs (BM-MSCs). Firstly, BM-MSCs display a limited proliferative capacity and a large variability of cell quality derived from different donors. Secondly, during ex-vivo expansion before possible therapeutic use, these cells quickly loose differentiation potential and decrease ability to produce protective factors. Importantly, survival capacity and stem cell functions of BM-MSCs derived from aged or diseased donors are profoundly impaired, and thus limit their therapeutic efficacy. Human pluripotent stem cells (i.e.hESCs/iPSCs) may provide an alternative source of functional MSCs for tissue repairs. Here we will introduce the generation, characterization and application of human ESC and iPSC-derived MSCs for the treatment of cardiovascular diseases.
DescriptionPlenary Lectures
Persistent Identifierhttp://hdl.handle.net/10722/165449
ISSN
2015 SCImago Journal Rankings: 0.102

 

DC FieldValueLanguage
dc.contributor.authorLian, Qen_US
dc.date.accessioned2012-09-20T08:18:17Z-
dc.date.available2012-09-20T08:18:17Z-
dc.date.issued2011en_US
dc.identifier.citationThe 15th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine (ICSM 2011), Hong Kong, China, 17 September 2011. In Journal of the Hong Kong College of Cardiology, 2011, v. 19 n. 2, p. 67, abstract no. PL5en_US
dc.identifier.issn1027-7811-
dc.identifier.urihttp://hdl.handle.net/10722/165449-
dc.descriptionPlenary Lectures-
dc.description.abstractRecent experimental and clinical studies suggest that transplantation of bone marrow derived mesenchymal stem cells (BM-MSCs) is an attractive therapeutic option for ischemic cardiovascular diseases. However, there are several potential limitations of using BM derived-MSCs (BM-MSCs). Firstly, BM-MSCs display a limited proliferative capacity and a large variability of cell quality derived from different donors. Secondly, during ex-vivo expansion before possible therapeutic use, these cells quickly loose differentiation potential and decrease ability to produce protective factors. Importantly, survival capacity and stem cell functions of BM-MSCs derived from aged or diseased donors are profoundly impaired, and thus limit their therapeutic efficacy. Human pluripotent stem cells (i.e.hESCs/iPSCs) may provide an alternative source of functional MSCs for tissue repairs. Here we will introduce the generation, characterization and application of human ESC and iPSC-derived MSCs for the treatment of cardiovascular diseases.-
dc.languageengen_US
dc.publisherHong Kong College of Cardiology. The Journal's web site is located at http://www.hkcchk.com/journals.php#3-
dc.relation.ispartofJournal of the Hong Kong College of Cardiologyen_US
dc.titleTherapeutic potential of pluripotent stem cell-derived mescenchymal stem cells in cardiovascular regenerationen_US
dc.typeConference_Paperen_US
dc.identifier.emailLian, Q: qzlian@hkucc.hku.hken_US
dc.identifier.authorityLian, Q=rp00267en_US
dc.identifier.hkuros208672en_US
dc.identifier.volume19-
dc.identifier.issue2-
dc.identifier.spage67, abstract no. PL5-
dc.identifier.epage67, abstract no. PL5-
dc.publisher.placeHong Kong-

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