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Conference Paper: Conventional electrospinning vs. emulsion electrospinning: a comparative study on the development of nanofibrous drug/biomolecule delivery vehicles

TitleConventional electrospinning vs. emulsion electrospinning: a comparative study on the development of nanofibrous drug/biomolecule delivery vehicles
Authors
KeywordsControlled-release
Drug delivery
Electrospinning
Emulsion electrospinning
Issue Date2011
PublisherTrans Tech Publications Ltd.. The Journal's web site is located at http://www.scitec.ch/1022-6680/
Citation
The 20th International Symposium on Processing and Fabrication of Advanced Materials (PFAM 2011), Hong Kong, 15-18 December 2011. In Advanced Materials Research, 2011, v. 410, p. 118-121 How to Cite?
AbstractOver the past decade, intensive research has been conducted on electrospinning of fibrous tissue engineering scaffolds and their applications in body tissue regeneration. For providing multifunctions and/or enhancing the biological performance, drugs or biomolecules can be incorporated in electrospun fibers using normally one of these techniques: (1) direct dissolution, (3) emulsion electrospinning, and (3) coaxial electrospinning. In this investigation, for constructing nanofibrous delivery vehicles, conventional electrospinning using polymer solutions with directly dissolved drugs or biomolecules and emulsion electrospinning were studied and compared. Bovine serum albumin (BSA) was used as a model protein and the drug was rifamycin, a hydrophobic antibiotic. A poly (lactic-co-glycolic acid) containing the protein or drug was electrospun into fibers. In these two routes of fabricating drug-or biomolecule-loaded nanofibers, different polymer concentrations and emulsion formulations were investigated. Various aspects of the fibrous delivery vehicles were investigated using several techniques and the in vitro release behaviour was studied.
DescriptionThis series vol. has title: Processing and Fabrication of Advanced Materials: selected, peer reviewed papers from the 20th International Symposium on Processing and Fabrication of Advanced Materials (PFAM XX)
Persistent Identifierhttp://hdl.handle.net/10722/165378
ISBN
ISSN
2015 SCImago Journal Rankings: 0.115

 

DC FieldValueLanguage
dc.contributor.authorWang, Cen_US
dc.contributor.authorTong, SNen_US
dc.contributor.authorTsz, YHen_US
dc.contributor.authorWang, Men_US
dc.date.accessioned2012-09-20T08:17:47Z-
dc.date.available2012-09-20T08:17:47Z-
dc.date.issued2011en_US
dc.identifier.citationThe 20th International Symposium on Processing and Fabrication of Advanced Materials (PFAM 2011), Hong Kong, 15-18 December 2011. In Advanced Materials Research, 2011, v. 410, p. 118-121en_US
dc.identifier.isbn978-3-03785-316-0-
dc.identifier.issn1022-6680-
dc.identifier.urihttp://hdl.handle.net/10722/165378-
dc.descriptionThis series vol. has title: Processing and Fabrication of Advanced Materials: selected, peer reviewed papers from the 20th International Symposium on Processing and Fabrication of Advanced Materials (PFAM XX)-
dc.description.abstractOver the past decade, intensive research has been conducted on electrospinning of fibrous tissue engineering scaffolds and their applications in body tissue regeneration. For providing multifunctions and/or enhancing the biological performance, drugs or biomolecules can be incorporated in electrospun fibers using normally one of these techniques: (1) direct dissolution, (3) emulsion electrospinning, and (3) coaxial electrospinning. In this investigation, for constructing nanofibrous delivery vehicles, conventional electrospinning using polymer solutions with directly dissolved drugs or biomolecules and emulsion electrospinning were studied and compared. Bovine serum albumin (BSA) was used as a model protein and the drug was rifamycin, a hydrophobic antibiotic. A poly (lactic-co-glycolic acid) containing the protein or drug was electrospun into fibers. In these two routes of fabricating drug-or biomolecule-loaded nanofibers, different polymer concentrations and emulsion formulations were investigated. Various aspects of the fibrous delivery vehicles were investigated using several techniques and the in vitro release behaviour was studied.-
dc.languageengen_US
dc.publisherTrans Tech Publications Ltd.. The Journal's web site is located at http://www.scitec.ch/1022-6680/-
dc.relation.ispartofAdvanced Materials Researchen_US
dc.subjectControlled-release-
dc.subjectDrug delivery-
dc.subjectElectrospinning-
dc.subjectEmulsion electrospinning-
dc.titleConventional electrospinning vs. emulsion electrospinning: a comparative study on the development of nanofibrous drug/biomolecule delivery vehiclesen_US
dc.typeConference_Paperen_US
dc.identifier.emailWang, C: mecwang@hku.hken_US
dc.identifier.emailWang, M: memwang@hku.hk-
dc.identifier.authorityWang, M=rp00185en_US
dc.identifier.doi10.4028/www.scientific.net/AMR.410.118-
dc.identifier.scopuseid_2-s2.0-84255189128-
dc.identifier.hkuros207466en_US
dc.identifier.hkuros207617-
dc.identifier.volume410-
dc.identifier.spage118en_US
dc.identifier.epage121en_US
dc.publisher.placeSwitzerland-
dc.description.otherThe 20th International Symposium on Processing and Fabrication of Advanced Materials (PFAM 2011), Hong Kong, 15-18 December 2011. In Advanced Materials Research, 2011, v. 410, p. 118-121-

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