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Conference Paper: PHBV tissue engineering scaffolds fabricated via emulsion freezing / freeze-drying: effects of processing parameters

TitlePHBV tissue engineering scaffolds fabricated via emulsion freezing / freeze-drying: effects of processing parameters
Authors
KeywordsScaffolds
Tissue engineering
Emulsion freezing
Freeze-drying
PHBV
Issue Date2011
PublisherInternational Proceedings of Chemical, Biological and Environmental Engineering. The Journal's web site is located at http://www.ipcbee.com/proceeding.htm
Citation
The 2011 International Conference on Biomedical Engineering and Technology ( ICBET 2011), Kuala Lumpur, Malaysia, 4-5 June 2011. In IPCBEE Proceedings, v. 11, p. 29-34 How to Cite?
AbstractBiodegradable polymers have been widely used for scaffolds in tissue engineering which aims to form completely natural tissues without leaving permanently synthetic element(s) in the human body. Poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) is a natural, biocompatible and biodegradable polymer suitable for tissue engineering applications. This paper reports the fabrication and characterization of three dimensional, highly porous PHBV scaffolds produced through the emulsion freezing/freeze-drying technique. PHBV emulsions having 2.5%, 5%, 7.5%, 10%, 12.5% (w/v) PHBV concentrations were used. Freezing and freeze-drying of polymer/solvent/water phase emulsions produced hard and tough scaffolds with interconnected pores having good handling quality. The porosity of scaffolds changed from 85% to 71% when the PHBV concentration in emulsions increased from 2.5% to 12.5%. Compressive mechanical properties of scaffolds were increased with increasing PHBV concentration. The scaffolds had pore sizes ranging from several microns to a few hundred microns.
DescriptionOpen Access Journal
Persistent Identifierhttp://hdl.handle.net/10722/165375
ISSN

 

DC FieldValueLanguage
dc.contributor.authorSultana, Nen_US
dc.contributor.authorWang, Men_US
dc.date.accessioned2012-09-20T08:17:47Z-
dc.date.available2012-09-20T08:17:47Z-
dc.date.issued2011en_US
dc.identifier.citationThe 2011 International Conference on Biomedical Engineering and Technology ( ICBET 2011), Kuala Lumpur, Malaysia, 4-5 June 2011. In IPCBEE Proceedings, v. 11, p. 29-34en_US
dc.identifier.issn2010-4618-
dc.identifier.urihttp://hdl.handle.net/10722/165375-
dc.descriptionOpen Access Journal-
dc.description.abstractBiodegradable polymers have been widely used for scaffolds in tissue engineering which aims to form completely natural tissues without leaving permanently synthetic element(s) in the human body. Poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) is a natural, biocompatible and biodegradable polymer suitable for tissue engineering applications. This paper reports the fabrication and characterization of three dimensional, highly porous PHBV scaffolds produced through the emulsion freezing/freeze-drying technique. PHBV emulsions having 2.5%, 5%, 7.5%, 10%, 12.5% (w/v) PHBV concentrations were used. Freezing and freeze-drying of polymer/solvent/water phase emulsions produced hard and tough scaffolds with interconnected pores having good handling quality. The porosity of scaffolds changed from 85% to 71% when the PHBV concentration in emulsions increased from 2.5% to 12.5%. Compressive mechanical properties of scaffolds were increased with increasing PHBV concentration. The scaffolds had pore sizes ranging from several microns to a few hundred microns.-
dc.languageengen_US
dc.publisherInternational Proceedings of Chemical, Biological and Environmental Engineering. The Journal's web site is located at http://www.ipcbee.com/proceeding.htm-
dc.relation.ispartofIPCBEE Proceedingsen_US
dc.subjectScaffolds-
dc.subjectTissue engineering-
dc.subjectEmulsion freezing-
dc.subjectFreeze-drying-
dc.subjectPHBV-
dc.titlePHBV tissue engineering scaffolds fabricated via emulsion freezing / freeze-drying: effects of processing parametersen_US
dc.typeConference_Paperen_US
dc.identifier.emailSultana, N: naznin@utm.myen_US
dc.identifier.emailWang, M: memwang@hku.hk-
dc.identifier.authorityWang, M=rp00185en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros207611en_US
dc.identifier.volume11en_US
dc.identifier.spage29en_US
dc.identifier.epage34en_US
dc.publisher.placeSingapore-
dc.description.otherThe 2011 International Conference on Biomedical Engineering and Technology ( ICBET 2011), Kuala Lumpur, Malaysia, 4-5 June 2011. In IPCBEE Proceedings, v. 11, p. 29-34-

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