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Conference Paper: Selective laser sintered nanocomposite scaffolds for bone tissue engineering

TitleSelective laser sintered nanocomposite scaffolds for bone tissue engineering
Authors
Issue Date2011
PublisherICAMT2011. The Abstracts's web site is located at http://www.meetmatt-conf.net/icmat2011pub/absSearch.asp
Citation
The 6th International Conference on Materials for Advanced Technologies (ICMAT 2011), Suntec, Singapore, 26 June-1 July 2011. In ICMAT2011 Abstracts, 2011 How to Cite?
AbstractIn scaffold-based bone tissue engineering, 3D scaffolds play a very important role in bone tissue regeneration. They provide a suitable microenvironment for seeded cells to attach, migrate, proliferate and differentiate, leading to new bone formation. As bone is a natural nanocomposite consisting of nano-sized bone apatite and collagen fibrils, synthetic, polymer-based biodegradable composites containing osteoconductive calcium phosphate (Ca-P) nanoparticles are naturally appealing as scaffold materials. For fabricating tissue engineering scaffolds, two groups of technologies, viz., non-designed manufacturing techniques and designed manufacturing techniques, can be used. The rise in recent years of designed manufacturing techniques, i.e., the application of rapid prototyping (RP) technologies in the tissue engineering field, stems from several reasons: scientific, technological or economical. These advanced technologies have distinctive advantages over some commonly used chemical engineering methods in scaffold fabrication. In this talk, an overview on the use of advanced manufacturing technologies by various research groups for constructing tissue engineering scaffolds is firstly given. For illustrating the purpose, practice and results of using advanced technologies to produce multifunctional scaffolds, our own research in employing selective laser sintering (SLS), a well-established RP technology, to make osteoconductive and osteoinductive bone tissue engineering scaffolds is introduced. Scaffold models of required features can be designed using data from computer-based medical imaging techniques (e.g., MRI). Good-quality Ca-P/PHBV nanocomposite scaffolds can be formed via SLS after process optimization. rhBMP-2 can be incorporated on surface-modified nanocomposite scaffolds. It can be released from the scaffolds in a controlled manner and cause osteogenic differentiation of hUC-MSCs in vitro. Both osteoconductivity and osteoinductivity provided by rhBMP-2 incorporated nanocomposite scaffolds stimulate bone tissue regeneration in vivo.
DescriptionSession - Symposium Y: Biomaterials and Tissue Engineering: ICMAT11-A-3662
Persistent Identifierhttp://hdl.handle.net/10722/165358

 

DC FieldValueLanguage
dc.contributor.authorWang, Men_US
dc.date.accessioned2012-09-20T08:17:44Z-
dc.date.available2012-09-20T08:17:44Z-
dc.date.issued2011en_US
dc.identifier.citationThe 6th International Conference on Materials for Advanced Technologies (ICMAT 2011), Suntec, Singapore, 26 June-1 July 2011. In ICMAT2011 Abstracts, 2011en_US
dc.identifier.urihttp://hdl.handle.net/10722/165358-
dc.descriptionSession - Symposium Y: Biomaterials and Tissue Engineering: ICMAT11-A-3662-
dc.description.abstractIn scaffold-based bone tissue engineering, 3D scaffolds play a very important role in bone tissue regeneration. They provide a suitable microenvironment for seeded cells to attach, migrate, proliferate and differentiate, leading to new bone formation. As bone is a natural nanocomposite consisting of nano-sized bone apatite and collagen fibrils, synthetic, polymer-based biodegradable composites containing osteoconductive calcium phosphate (Ca-P) nanoparticles are naturally appealing as scaffold materials. For fabricating tissue engineering scaffolds, two groups of technologies, viz., non-designed manufacturing techniques and designed manufacturing techniques, can be used. The rise in recent years of designed manufacturing techniques, i.e., the application of rapid prototyping (RP) technologies in the tissue engineering field, stems from several reasons: scientific, technological or economical. These advanced technologies have distinctive advantages over some commonly used chemical engineering methods in scaffold fabrication. In this talk, an overview on the use of advanced manufacturing technologies by various research groups for constructing tissue engineering scaffolds is firstly given. For illustrating the purpose, practice and results of using advanced technologies to produce multifunctional scaffolds, our own research in employing selective laser sintering (SLS), a well-established RP technology, to make osteoconductive and osteoinductive bone tissue engineering scaffolds is introduced. Scaffold models of required features can be designed using data from computer-based medical imaging techniques (e.g., MRI). Good-quality Ca-P/PHBV nanocomposite scaffolds can be formed via SLS after process optimization. rhBMP-2 can be incorporated on surface-modified nanocomposite scaffolds. It can be released from the scaffolds in a controlled manner and cause osteogenic differentiation of hUC-MSCs in vitro. Both osteoconductivity and osteoinductivity provided by rhBMP-2 incorporated nanocomposite scaffolds stimulate bone tissue regeneration in vivo.-
dc.languageengen_US
dc.publisherICAMT2011. The Abstracts's web site is located at http://www.meetmatt-conf.net/icmat2011pub/absSearch.asp-
dc.relation.ispartofICMAT2011 Abstractsen_US
dc.titleSelective laser sintered nanocomposite scaffolds for bone tissue engineeringen_US
dc.typeConference_Paperen_US
dc.identifier.emailWang, M: memwang@hku.hken_US
dc.identifier.authorityWang, M=rp00185en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros207560en_US
dc.publisher.placeSingapore-
dc.description.otherThe 6th International Conference on Materials for Advanced Technologies (ICMAT 2011), Suntec, Singapore, 26 June-1 July 2011. In ICMAT2011 Abstracts, 2011-

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