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Conference Paper: Biexponential diffusion tensor analysis of myocardial structural alteration in rabbit models with myocardium infarction
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TitleBiexponential diffusion tensor analysis of myocardial structural alteration in rabbit models with myocardium infarction
 
AuthorsWu, Y
Zou, C
Liu, W
Yang, W
Jiang, K
Wu, EX
 
Issue Date2012
 
PublisherInternational Society of Magnetic Resonance in Medicine.
 
CitationThe 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 3775 [How to Cite?]
 
AbstractWater diffusion behavior in some tissues was found to not comply with Gaussian manner, leading to diffusion strength dependence of DTI index characterization. In this study, infarcted myocardial structural alteration was investigated using biexponential model, which was proved to better fit of diffusion signal decay. DTI results showed that in both infarct and adjacent regions fast radial diffusivity increased due to extracellular and microvascular compartment augmentation along radial direction, leading to enhancement of fast mean diffusivity. Meanwhile, decrease of both fast and slow FA was observed as result of fiber integrity loss and fast radial diffusivity enhancement. These findings were validated by histological observations. The current study suggested that biexponential diffusion function could be utilized as a tool to monitor and detect myocardial morphological alteration and structural degradation by probing multi-compartment diffusion behavior compared to conventional used monoexponential diffusion model.
 
DescriptionTheme: Adapting MR in a Changing World
Electronic Poster Session - Cardiovascular - Myocardial Tissue Characterization & Spectroscopy: no. 3775 (computer no. 11)
 
DC FieldValue
dc.contributor.authorWu, Y
 
dc.contributor.authorZou, C
 
dc.contributor.authorLiu, W
 
dc.contributor.authorYang, W
 
dc.contributor.authorJiang, K
 
dc.contributor.authorWu, EX
 
dc.date.accessioned2012-09-20T08:16:12Z
 
dc.date.available2012-09-20T08:16:12Z
 
dc.date.issued2012
 
dc.description.abstractWater diffusion behavior in some tissues was found to not comply with Gaussian manner, leading to diffusion strength dependence of DTI index characterization. In this study, infarcted myocardial structural alteration was investigated using biexponential model, which was proved to better fit of diffusion signal decay. DTI results showed that in both infarct and adjacent regions fast radial diffusivity increased due to extracellular and microvascular compartment augmentation along radial direction, leading to enhancement of fast mean diffusivity. Meanwhile, decrease of both fast and slow FA was observed as result of fiber integrity loss and fast radial diffusivity enhancement. These findings were validated by histological observations. The current study suggested that biexponential diffusion function could be utilized as a tool to monitor and detect myocardial morphological alteration and structural degradation by probing multi-compartment diffusion behavior compared to conventional used monoexponential diffusion model.
 
dc.description.naturelink_to_OA_fulltext
 
dc.descriptionTheme: Adapting MR in a Changing World
 
dc.descriptionElectronic Poster Session - Cardiovascular - Myocardial Tissue Characterization & Spectroscopy: no. 3775 (computer no. 11)
 
dc.description.otherThe 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 3775
 
dc.identifier.citationThe 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 3775 [How to Cite?]
 
dc.identifier.hkuros207487
 
dc.identifier.urihttp://hdl.handle.net/10722/165198
 
dc.languageeng
 
dc.publisherInternational Society of Magnetic Resonance in Medicine.
 
dc.publisher.placeAustralia
 
dc.relation.ispartofProceedings of the 20th Annual Meeting of the International Society of Magnetic Resonance in Medicine, ISMRM 2012
 
dc.titleBiexponential diffusion tensor analysis of myocardial structural alteration in rabbit models with myocardium infarction
 
dc.typeConference_Paper
 
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<contributor.author>Jiang, K</contributor.author>
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