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Conference Paper: Biexponential diffusion tensor analysis of myocardial structural alteration in rabbit models with myocardium infarction

TitleBiexponential diffusion tensor analysis of myocardial structural alteration in rabbit models with myocardium infarction
Authors
Issue Date2012
PublisherInternational Society of Magnetic Resonance in Medicine.
Citation
The 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 3775 How to Cite?
Abstract
Water diffusion behavior in some tissues was found to not comply with Gaussian manner, leading to diffusion strength dependence of DTI index characterization. In this study, infarcted myocardial structural alteration was investigated using biexponential model, which was proved to better fit of diffusion signal decay. DTI results showed that in both infarct and adjacent regions fast radial diffusivity increased due to extracellular and microvascular compartment augmentation along radial direction, leading to enhancement of fast mean diffusivity. Meanwhile, decrease of both fast and slow FA was observed as result of fiber integrity loss and fast radial diffusivity enhancement. These findings were validated by histological observations. The current study suggested that biexponential diffusion function could be utilized as a tool to monitor and detect myocardial morphological alteration and structural degradation by probing multi-compartment diffusion behavior compared to conventional used monoexponential diffusion model.
DescriptionTheme: Adapting MR in a Changing World
Persistent Identifierhttp://hdl.handle.net/10722/165198

 

DC FieldValueLanguage
dc.contributor.authorWu, Yen_US
dc.contributor.authorZou, Cen_US
dc.contributor.authorLiu, Wen_US
dc.contributor.authorYang, Wen_US
dc.contributor.authorJiang, Ken_US
dc.contributor.authorWu, EXen_US
dc.date.accessioned2012-09-20T08:16:12Z-
dc.date.available2012-09-20T08:16:12Z-
dc.date.issued2012en_US
dc.identifier.citationThe 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 3775en_US
dc.identifier.urihttp://hdl.handle.net/10722/165198-
dc.descriptionTheme: Adapting MR in a Changing World-
dc.descriptionElectronic Poster Session - Cardiovascular - Myocardial Tissue Characterization & Spectroscopy: no. 3775 (computer no. 11)-
dc.description.abstractWater diffusion behavior in some tissues was found to not comply with Gaussian manner, leading to diffusion strength dependence of DTI index characterization. In this study, infarcted myocardial structural alteration was investigated using biexponential model, which was proved to better fit of diffusion signal decay. DTI results showed that in both infarct and adjacent regions fast radial diffusivity increased due to extracellular and microvascular compartment augmentation along radial direction, leading to enhancement of fast mean diffusivity. Meanwhile, decrease of both fast and slow FA was observed as result of fiber integrity loss and fast radial diffusivity enhancement. These findings were validated by histological observations. The current study suggested that biexponential diffusion function could be utilized as a tool to monitor and detect myocardial morphological alteration and structural degradation by probing multi-compartment diffusion behavior compared to conventional used monoexponential diffusion model.-
dc.languageengen_US
dc.publisherInternational Society of Magnetic Resonance in Medicine.-
dc.relation.ispartofProceedings of the 20th Annual Meeting of the International Society of Magnetic Resonance in Medicine, ISMRM 2012en_US
dc.titleBiexponential diffusion tensor analysis of myocardial structural alteration in rabbit models with myocardium infarctionen_US
dc.typeConference_Paperen_US
dc.identifier.emailWu, EX: ewu@eee.hku.hken_US
dc.identifier.authorityWu, EX=rp00193en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros207487en_US
dc.publisher.placeAustralia-
dc.description.otherThe 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 3775-

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