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Conference Paper: In vivo Mn-enhanced MRI for visuotopic mapping in normal and reorganized brains
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TitleIn vivo Mn-enhanced MRI for visuotopic mapping in normal and reorganized brains
 
AuthorsChan, KC
Wu, EX
 
Issue Date2012
 
PublisherInternational Society of Magnetic Resonance in Medicine.
 
CitationThe 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 0727 [How to Cite?]
 
AbstractThis study employed localized Mn-enhanced MRI via 3 different routes of Mn2+ administrations for visuotopic brain mapping of retinal, callosal and transsynaptic connections in the normal and reorganized rat brains. In normal brains, fractionated intravitreal Mn2+ injection resulted in Mn enhancements in the contralateral superior colliculus (SC) and lateral geniculate nucleus (LGN) by 45-60% at 1-3 days after initial Mn2+ injection, and in the contralateral primary visual cortex (V1) by about 10% at 2-3 days after initial Mn2+ injection. Direct, single-dose Mn2+ injection to the LGN resulted in Mn enhancement by 8-11% in SC, and 13-21% in V1 of the ipsilateral hemisphere at 8 to 24 hours after Mn2+ administration. Intracortical, single-dose Mn2+ injection to the visual cortex resulted in Mn enhancement by 15-26% in ipsilateral SC, 53-65% in ipsilateral LGN, 17-25% in contralateral V1/V2 transition zone, and 32-34% in the splenium of corpus callosum at 8 to 24 hours after Mn2+ administration. Notably, some patchy patterns were apparent near the V1/V2 border of the contralateral hemisphere. Upon intracortical Mn injection, animals which had undergone neonatal binocular enucleation exhibited larger projection volumes by about 74% near the V1/V2 border of the contralateral hemisphere compared to normal rat brains at 3 months old. The current results demonstrated the sensitivity of MEMRI for assessing the neuroarchitecture of the visual brains in vivo without depth-limitation, and may possess great potentials for studying the basic neural components in the visual system longitudinally during development, plasticity, therapeutic interventions and genetic modifications.
 
DescriptionTheme: Adapting MR in a Changing World
Oral Presentation - Session 72: Manganese Enhanced MRI (MEMRI): no. 0727
 
DC FieldValue
dc.contributor.authorChan, KC
 
dc.contributor.authorWu, EX
 
dc.date.accessioned2012-09-20T08:16:11Z
 
dc.date.available2012-09-20T08:16:11Z
 
dc.date.issued2012
 
dc.description.abstractThis study employed localized Mn-enhanced MRI via 3 different routes of Mn2+ administrations for visuotopic brain mapping of retinal, callosal and transsynaptic connections in the normal and reorganized rat brains. In normal brains, fractionated intravitreal Mn2+ injection resulted in Mn enhancements in the contralateral superior colliculus (SC) and lateral geniculate nucleus (LGN) by 45-60% at 1-3 days after initial Mn2+ injection, and in the contralateral primary visual cortex (V1) by about 10% at 2-3 days after initial Mn2+ injection. Direct, single-dose Mn2+ injection to the LGN resulted in Mn enhancement by 8-11% in SC, and 13-21% in V1 of the ipsilateral hemisphere at 8 to 24 hours after Mn2+ administration. Intracortical, single-dose Mn2+ injection to the visual cortex resulted in Mn enhancement by 15-26% in ipsilateral SC, 53-65% in ipsilateral LGN, 17-25% in contralateral V1/V2 transition zone, and 32-34% in the splenium of corpus callosum at 8 to 24 hours after Mn2+ administration. Notably, some patchy patterns were apparent near the V1/V2 border of the contralateral hemisphere. Upon intracortical Mn injection, animals which had undergone neonatal binocular enucleation exhibited larger projection volumes by about 74% near the V1/V2 border of the contralateral hemisphere compared to normal rat brains at 3 months old. The current results demonstrated the sensitivity of MEMRI for assessing the neuroarchitecture of the visual brains in vivo without depth-limitation, and may possess great potentials for studying the basic neural components in the visual system longitudinally during development, plasticity, therapeutic interventions and genetic modifications.
 
dc.description.naturelink_to_OA_fulltext
 
dc.descriptionTheme: Adapting MR in a Changing World
 
dc.descriptionOral Presentation - Session 72: Manganese Enhanced MRI (MEMRI): no. 0727
 
dc.description.otherThe 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 0727
 
dc.identifier.citationThe 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 0727 [How to Cite?]
 
dc.identifier.hkuros207485
 
dc.identifier.urihttp://hdl.handle.net/10722/165196
 
dc.languageeng
 
dc.publisherInternational Society of Magnetic Resonance in Medicine.
 
dc.publisher.placeAustralia
 
dc.relation.ispartofProceedings of the 20th Annual Meeting of the International Society of Magnetic Resonance in Medicine, ISMRM 2012
 
dc.titleIn vivo Mn-enhanced MRI for visuotopic mapping in normal and reorganized brains
 
dc.typeConference_Paper
 
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