Conference Paper: In vivo Mn-enhanced MRI for visuotopic mapping in normal and reorganized brains
| Title | In vivo Mn-enhanced MRI for visuotopic mapping in normal and reorganized brains |
|---|---|
| Authors | Chan, KC Wu, EX |
| Issue Date | 2012 |
| Publisher | International Society of Magnetic Resonance in Medicine. |
| Citation | The 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 0727 [How to Cite?] |
| Abstract | This study employed localized Mn-enhanced MRI via 3 different routes of Mn2+ administrations for visuotopic brain mapping of retinal, callosal and transsynaptic connections in the normal and reorganized rat brains. In normal brains, fractionated intravitreal Mn2+ injection resulted in Mn enhancements in the contralateral superior colliculus (SC) and lateral geniculate nucleus (LGN) by 45-60% at 1-3 days after initial Mn2+ injection, and in the contralateral primary visual cortex (V1) by about 10% at 2-3 days after initial Mn2+ injection. Direct, single-dose Mn2+ injection to the LGN resulted in Mn enhancement by 8-11% in SC, and 13-21% in V1 of the ipsilateral hemisphere at 8 to 24 hours after Mn2+ administration. Intracortical, single-dose Mn2+ injection to the visual cortex resulted in Mn enhancement by 15-26% in ipsilateral SC, 53-65% in ipsilateral LGN, 17-25% in contralateral V1/V2 transition zone, and 32-34% in the splenium of corpus callosum at 8 to 24 hours after Mn2+ administration. Notably, some patchy patterns were apparent near the V1/V2 border of the contralateral hemisphere. Upon intracortical Mn injection, animals which had undergone neonatal binocular enucleation exhibited larger projection volumes by about 74% near the V1/V2 border of the contralateral hemisphere compared to normal rat brains at 3 months old. The current results demonstrated the sensitivity of MEMRI for assessing the neuroarchitecture of the visual brains in vivo without depth-limitation, and may possess great potentials for studying the basic neural components in the visual system longitudinally during development, plasticity, therapeutic interventions and genetic modifications. |
| Description | Theme: Adapting MR in a Changing World Oral Presentation - Session 72: Manganese Enhanced MRI (MEMRI): no. 0727 |
| dc.contributor.author | Chan, KC |
|---|---|
| dc.contributor.author | Wu, EX |
| dc.date.accessioned | 2012-09-20T08:16:11Z |
| dc.date.available | 2012-09-20T08:16:11Z |
| dc.date.issued | 2012 |
| dc.description.abstract | This study employed localized Mn-enhanced MRI via 3 different routes of Mn2+ administrations for visuotopic brain mapping of retinal, callosal and transsynaptic connections in the normal and reorganized rat brains. In normal brains, fractionated intravitreal Mn2+ injection resulted in Mn enhancements in the contralateral superior colliculus (SC) and lateral geniculate nucleus (LGN) by 45-60% at 1-3 days after initial Mn2+ injection, and in the contralateral primary visual cortex (V1) by about 10% at 2-3 days after initial Mn2+ injection. Direct, single-dose Mn2+ injection to the LGN resulted in Mn enhancement by 8-11% in SC, and 13-21% in V1 of the ipsilateral hemisphere at 8 to 24 hours after Mn2+ administration. Intracortical, single-dose Mn2+ injection to the visual cortex resulted in Mn enhancement by 15-26% in ipsilateral SC, 53-65% in ipsilateral LGN, 17-25% in contralateral V1/V2 transition zone, and 32-34% in the splenium of corpus callosum at 8 to 24 hours after Mn2+ administration. Notably, some patchy patterns were apparent near the V1/V2 border of the contralateral hemisphere. Upon intracortical Mn injection, animals which had undergone neonatal binocular enucleation exhibited larger projection volumes by about 74% near the V1/V2 border of the contralateral hemisphere compared to normal rat brains at 3 months old. The current results demonstrated the sensitivity of MEMRI for assessing the neuroarchitecture of the visual brains in vivo without depth-limitation, and may possess great potentials for studying the basic neural components in the visual system longitudinally during development, plasticity, therapeutic interventions and genetic modifications. |
| dc.description.nature | link_to_OA_fulltext |
| dc.description | Theme: Adapting MR in a Changing World |
| dc.description | Oral Presentation - Session 72: Manganese Enhanced MRI (MEMRI): no. 0727 |
| dc.description.other | The 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 0727 |
| dc.identifier.citation | The 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 0727 [How to Cite?] |
| dc.identifier.hkuros | 207485 |
| dc.identifier.uri | http://hdl.handle.net/10722/165196 |
| dc.language | eng |
| dc.publisher | International Society of Magnetic Resonance in Medicine. |
| dc.publisher.place | Australia |
| dc.relation.ispartof | Proceedings of the 20th Annual Meeting of the International Society of Magnetic Resonance in Medicine, ISMRM 2012 |
| dc.title | In vivo Mn-enhanced MRI for visuotopic mapping in normal and reorganized brains |
| dc.type | Conference_Paper |