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Conference Paper: Age-related iron deposition in deep gray nuclei in infants detected by 1.5T MRI:R2* versus susceptibility phase values

TitleAge-related iron deposition in deep gray nuclei in infants detected by 1.5T MRI:R2* versus susceptibility phase values
Authors
Issue Date2012
PublisherInternational Society of Magnetic Resonance in Medicine.
Citation
The 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 0100 How to Cite?
Abstract
This study aims to evaluate the R2* and susceptibility phase values of deep gray nuclei in infants for study of early brain development by using susceptibility weighted imaging. 56 infants with postmenstrual age (PMA) range of 37-91 weeks were examined by using an ESWAN (enhanced T2* weighted angiography) sequence. R2* and phase values were obtained for caudate nucleus, putamen, globus pallidus, thalamus, red nucleus and substantia nigra. R2* values showed a significant and positive correlation with PMA, as well as the reference iron concentrations calculated using an empirical equation that was derived in an earlier postmortem study. No significant linear correlation was observed between phase value, PMA and iron concentrations in each gray matter structure. Therefore, R2* presents a more sensitive parameter than phase value for in vivo estimation of brain iron deposition in infants.
DescriptionTheme: Adapting MR in a Changing World
Persistent Identifierhttp://hdl.handle.net/10722/165188

 

DC FieldValueLanguage
dc.contributor.authorNing, Nen_US
dc.contributor.authorZhang, Len_US
dc.contributor.authorZhang, Yen_US
dc.contributor.authorRen, ZQen_US
dc.contributor.authorWu, EXen_US
dc.contributor.authorYang, Jen_US
dc.date.accessioned2012-09-20T08:16:08Z-
dc.date.available2012-09-20T08:16:08Z-
dc.date.issued2012en_US
dc.identifier.citationThe 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 0100en_US
dc.identifier.urihttp://hdl.handle.net/10722/165188-
dc.descriptionTheme: Adapting MR in a Changing World-
dc.descriptionOral Presentation - Session 10 Normal Developing Human Brain - Advanced Imaging: no. 0100-
dc.description.abstractThis study aims to evaluate the R2* and susceptibility phase values of deep gray nuclei in infants for study of early brain development by using susceptibility weighted imaging. 56 infants with postmenstrual age (PMA) range of 37-91 weeks were examined by using an ESWAN (enhanced T2* weighted angiography) sequence. R2* and phase values were obtained for caudate nucleus, putamen, globus pallidus, thalamus, red nucleus and substantia nigra. R2* values showed a significant and positive correlation with PMA, as well as the reference iron concentrations calculated using an empirical equation that was derived in an earlier postmortem study. No significant linear correlation was observed between phase value, PMA and iron concentrations in each gray matter structure. Therefore, R2* presents a more sensitive parameter than phase value for in vivo estimation of brain iron deposition in infants.-
dc.languageengen_US
dc.publisherInternational Society of Magnetic Resonance in Medicine.-
dc.relation.ispartofProceedings of the 20th Annual Meeting of the International Society of Magnetic Resonance in Medicine, ISMRM 2012en_US
dc.titleAge-related iron deposition in deep gray nuclei in infants detected by 1.5T MRI:R2* versus susceptibility phase valuesen_US
dc.typeConference_Paperen_US
dc.identifier.emailWu, EX: ewu@eee.hku.hken_US
dc.identifier.authorityWu, EX=rp00193en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros207313en_US
dc.publisher.placeAustralia-
dc.description.otherThe 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 0100-

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