Conference Paper: Age-related iron deposition in deep gray nuclei in infants detected by 1.5T MRI:R2* versus susceptibility phase values
| Title | Age-related iron deposition in deep gray nuclei in infants detected by 1.5T MRI:R2* versus susceptibility phase values |
|---|---|
| Authors | Ning, N Zhang, L Zhang, Y Ren, ZQ Wu, EX Yang, J |
| Issue Date | 2012 |
| Publisher | International Society of Magnetic Resonance in Medicine. |
| Citation | The 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 0100 [How to Cite?] |
| Abstract | This study aims to evaluate the R2* and susceptibility phase values of deep gray nuclei in infants for study of early brain development by using susceptibility weighted imaging. 56 infants with postmenstrual age (PMA) range of 37-91 weeks were examined by using an ESWAN (enhanced T2* weighted angiography) sequence. R2* and phase values were obtained for caudate nucleus, putamen, globus pallidus, thalamus, red nucleus and substantia nigra. R2* values showed a significant and positive correlation with PMA, as well as the reference iron concentrations calculated using an empirical equation that was derived in an earlier postmortem study. No significant linear correlation was observed between phase value, PMA and iron concentrations in each gray matter structure. Therefore, R2* presents a more sensitive parameter than phase value for in vivo estimation of brain iron deposition in infants. |
| Description | Theme: Adapting MR in a Changing World Oral Presentation - Session 10 Normal Developing Human Brain - Advanced Imaging: no. 0100 |
| dc.contributor.author | Ning, N |
|---|---|
| dc.contributor.author | Zhang, L |
| dc.contributor.author | Zhang, Y |
| dc.contributor.author | Ren, ZQ |
| dc.contributor.author | Wu, EX |
| dc.contributor.author | Yang, J |
| dc.date.accessioned | 2012-09-20T08:16:08Z |
| dc.date.available | 2012-09-20T08:16:08Z |
| dc.date.issued | 2012 |
| dc.description.abstract | This study aims to evaluate the R2* and susceptibility phase values of deep gray nuclei in infants for study of early brain development by using susceptibility weighted imaging. 56 infants with postmenstrual age (PMA) range of 37-91 weeks were examined by using an ESWAN (enhanced T2* weighted angiography) sequence. R2* and phase values were obtained for caudate nucleus, putamen, globus pallidus, thalamus, red nucleus and substantia nigra. R2* values showed a significant and positive correlation with PMA, as well as the reference iron concentrations calculated using an empirical equation that was derived in an earlier postmortem study. No significant linear correlation was observed between phase value, PMA and iron concentrations in each gray matter structure. Therefore, R2* presents a more sensitive parameter than phase value for in vivo estimation of brain iron deposition in infants. |
| dc.description.nature | link_to_OA_fulltext |
| dc.description | Theme: Adapting MR in a Changing World |
| dc.description | Oral Presentation - Session 10 Normal Developing Human Brain - Advanced Imaging: no. 0100 |
| dc.description.other | The 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 0100 |
| dc.identifier.citation | The 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 0100 [How to Cite?] |
| dc.identifier.hkuros | 207313 |
| dc.identifier.uri | http://hdl.handle.net/10722/165188 |
| dc.language | eng |
| dc.publisher | International Society of Magnetic Resonance in Medicine. |
| dc.publisher.place | Australia |
| dc.relation.ispartof | Proceedings of the 20th Annual Meeting of the International Society of Magnetic Resonance in Medicine, ISMRM 2012 |
| dc.title | Age-related iron deposition in deep gray nuclei in infants detected by 1.5T MRI:R2* versus susceptibility phase values |
| dc.type | Conference_Paper |