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Conference Paper: Can stem cells home to the injured intervertebral disc via intravenous infusion? A murine model

TitleCan stem cells home to the injured intervertebral disc via intravenous infusion? A murine model
Authors
Issue Date2012
PublisherGeorg Thieme Verlag. The Journal's web site is located at http://www.thieme.com/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=1351&category_id=90&option=com_virtuemart&Itemid=53
Citation
The World Forum for Spine Research (WFSR 2012): The Intervertebral Disc - from Degeneration to Pain, Helsinki, Finland, 18-21 June 2012. In Global Spine Journal, 2012, v. 2 n. S1, ST15 How to Cite?
AbstractINTRODUCTION: Patients who suffer traumatic injury of the spine can also present with intervertebral disk injury, both of which are associated with low back pain (LBP). While conventional treatments mainly serve to alleviate pain, these treatments are not biological. Various biological therapies such as growth hormones/factors and cells have been studied for treatment of different conditions including that of IVD degeneration, which is also associated with LBP. In various animal models, such biological therapies have been demonstrated to slow or even reverse degeneration.1,2 The use of stem cells to treat injury is very promising due to their ability to regenerate and differentiate into other cell types—thus lies their potential to repair tissue damage. Of great interest is a population of cord-blood stem cells with expanded multipotency and mesenchymal stem cell (MSC)-like properties.3 These cells are reported to home to injured sites after intravenous (IV) injection and are demonstrated in a rat spinal cord injury model to induce beneficial effects to injured rats.4 The use of such homing stem cells is advantageous as this could potentially bypass invasive surgery. We investigated the potential of these stem cells to aid IVD repair by determining (1) if these cells could home to injured IVD after intravenous infusion and (2) induce any ...
DescriptionSession - Short Talks: ST15
Persistent Identifierhttp://hdl.handle.net/10722/165095
ISSN
2015 SCImago Journal Rankings: 0.108

 

DC FieldValueLanguage
dc.contributor.authorTam, Ven_US
dc.contributor.authorRogers, Ien_US
dc.contributor.authorChan, Den_US
dc.contributor.authorCheung, Ken_US
dc.date.accessioned2012-09-20T08:14:44Z-
dc.date.available2012-09-20T08:14:44Z-
dc.date.issued2012en_US
dc.identifier.citationThe World Forum for Spine Research (WFSR 2012): The Intervertebral Disc - from Degeneration to Pain, Helsinki, Finland, 18-21 June 2012. In Global Spine Journal, 2012, v. 2 n. S1, ST15en_US
dc.identifier.issn2192-5682-
dc.identifier.urihttp://hdl.handle.net/10722/165095-
dc.descriptionSession - Short Talks: ST15-
dc.description.abstractINTRODUCTION: Patients who suffer traumatic injury of the spine can also present with intervertebral disk injury, both of which are associated with low back pain (LBP). While conventional treatments mainly serve to alleviate pain, these treatments are not biological. Various biological therapies such as growth hormones/factors and cells have been studied for treatment of different conditions including that of IVD degeneration, which is also associated with LBP. In various animal models, such biological therapies have been demonstrated to slow or even reverse degeneration.1,2 The use of stem cells to treat injury is very promising due to their ability to regenerate and differentiate into other cell types—thus lies their potential to repair tissue damage. Of great interest is a population of cord-blood stem cells with expanded multipotency and mesenchymal stem cell (MSC)-like properties.3 These cells are reported to home to injured sites after intravenous (IV) injection and are demonstrated in a rat spinal cord injury model to induce beneficial effects to injured rats.4 The use of such homing stem cells is advantageous as this could potentially bypass invasive surgery. We investigated the potential of these stem cells to aid IVD repair by determining (1) if these cells could home to injured IVD after intravenous infusion and (2) induce any ...-
dc.languageengen_US
dc.publisherGeorg Thieme Verlag. The Journal's web site is located at http://www.thieme.com/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=1351&category_id=90&option=com_virtuemart&Itemid=53-
dc.relation.ispartofGlobal Spine Journalen_US
dc.rightsGlobal Spine Journal. Copyright © Georg Thieme Verlag.-
dc.titleCan stem cells home to the injured intervertebral disc via intravenous infusion? A murine modelen_US
dc.typeConference_Paperen_US
dc.identifier.emailTam, V: vivtam@hku.hken_US
dc.identifier.emailChan, D: chand@hku.hken_US
dc.identifier.emailCheung, K: cheungmc@hku.hken_US
dc.identifier.authorityChan, D=rp00540en_US
dc.identifier.authorityCheung, K=rp00387en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1055/s-0032-1319884-
dc.identifier.hkuros210238en_US
dc.identifier.volume2-
dc.identifier.issueS1-
dc.publisher.placeGermany-
dc.customcontrol.immutablesml 130319-

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