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Article: Electronic chemical pathology consultation service and dried blood spot metabolic screening in hospital patients
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TitleElectronic chemical pathology consultation service and dried blood spot metabolic screening in hospital patients
 
AuthorsMak, CM2 3
Siu, WK2 3
Law, CY2 1
Wong, CK3
Lee, HK3
Yeung, S3
Sham, CO3
Tse, K3
Lee, HHC2
Chen, SPL2
Ching, CK2
Au, CK2
Poon, WT2
Lam, CW1
Kwong, NS3
Chan, AYW2
 
Issue Date2012
 
PublisherBMJ Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/
 
CitationJournal of Clinical Pathology, 2012, v. 65 n. 12, p. 1141-1145 [How to Cite?]
DOI: http://dx.doi.org/10.1136/jclinpath-2012-200837
 
AbstractAIM: Inborn errors of metabolism (IEM) are an unpopular and difficult subject and most clinicians are unfamiliar with them. Although chemical pathologists have a long-standing practice in advising test strategy and result interpretation especially from primary care, such consultations are usually informal, unstructured and those related to IEM are infrequently requested. This study aims to provide a formal electronic consultation service and to apply tandem mass spectrometry-based dried blood spot metabolic screening (DBSM) as a rapid first-line test for patients suspected of IEM. METHODS: DBSM and a chemical pathology consultation were ordered through the hospital computer terminals. DBSM detected 29 metabolic disorders. The clinical data and metabolic results for the 12-month period were reviewed. RESULTS: There were 279 consultations of which 209 were initiated by paediatricians and 70 by adult physicians. The main reasons for consultation were developmental delay, neurological abnormalities, unexplained biochemical abnormalities and monitoring of patients with IEM. There were 158 DBSM requests. One positive case of isovaleric acidaemia was detected. CONCLUSIONS: All high-risk paediatric patients should have a DBSM and a timely electronic chemical pathology consultation as a rapid and cost-effective first-line screening. Provision of a visible, accessible and helpful consultation service enables professional reimbursement.
 
ISSN0021-9746
2013 Impact Factor: 2.551
 
DOIhttp://dx.doi.org/10.1136/jclinpath-2012-200837
 
DC FieldValue
dc.contributor.authorMak, CM
 
dc.contributor.authorSiu, WK
 
dc.contributor.authorLaw, CY
 
dc.contributor.authorWong, CK
 
dc.contributor.authorLee, HK
 
dc.contributor.authorYeung, S
 
dc.contributor.authorSham, CO
 
dc.contributor.authorTse, K
 
dc.contributor.authorLee, HHC
 
dc.contributor.authorChen, SPL
 
dc.contributor.authorChing, CK
 
dc.contributor.authorAu, CK
 
dc.contributor.authorPoon, WT
 
dc.contributor.authorLam, CW
 
dc.contributor.authorKwong, NS
 
dc.contributor.authorChan, AYW
 
dc.date.accessioned2012-09-20T08:11:00Z
 
dc.date.available2012-09-20T08:11:00Z
 
dc.date.issued2012
 
dc.description.abstractAIM: Inborn errors of metabolism (IEM) are an unpopular and difficult subject and most clinicians are unfamiliar with them. Although chemical pathologists have a long-standing practice in advising test strategy and result interpretation especially from primary care, such consultations are usually informal, unstructured and those related to IEM are infrequently requested. This study aims to provide a formal electronic consultation service and to apply tandem mass spectrometry-based dried blood spot metabolic screening (DBSM) as a rapid first-line test for patients suspected of IEM. METHODS: DBSM and a chemical pathology consultation were ordered through the hospital computer terminals. DBSM detected 29 metabolic disorders. The clinical data and metabolic results for the 12-month period were reviewed. RESULTS: There were 279 consultations of which 209 were initiated by paediatricians and 70 by adult physicians. The main reasons for consultation were developmental delay, neurological abnormalities, unexplained biochemical abnormalities and monitoring of patients with IEM. There were 158 DBSM requests. One positive case of isovaleric acidaemia was detected. CONCLUSIONS: All high-risk paediatric patients should have a DBSM and a timely electronic chemical pathology consultation as a rapid and cost-effective first-line screening. Provision of a visible, accessible and helpful consultation service enables professional reimbursement.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationJournal of Clinical Pathology, 2012, v. 65 n. 12, p. 1141-1145 [How to Cite?]
DOI: http://dx.doi.org/10.1136/jclinpath-2012-200837
 
dc.identifier.doihttp://dx.doi.org/10.1136/jclinpath-2012-200837
 
dc.identifier.epage1145
 
dc.identifier.hkuros208493
 
dc.identifier.hkuros222697
 
dc.identifier.issn0021-9746
2013 Impact Factor: 2.551
 
dc.identifier.issue12
 
dc.identifier.pmid22888119
 
dc.identifier.scopuseid_2-s2.0-84870067069
 
dc.identifier.spage1141
 
dc.identifier.urihttp://hdl.handle.net/10722/164852
 
dc.identifier.volume65
 
dc.languageeng
 
dc.publisherBMJ Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofJournal of Clinical Pathology
 
dc.rightsJournal of Clinical Pathology. Copyright © BMJ Publishing Group.
 
dc.rightsThis article has been accepted for publication in [Journal of Clinical Pathology]. The definitive copyedited, typeset version [Journal of Clinical Pathology, 2012, v. 65 n. 12, p. 1141-1145] is available online at: www.jcp.bmj.com
 
dc.titleElectronic chemical pathology consultation service and dried blood spot metabolic screening in hospital patients
 
dc.typeArticle
 
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<contributor.author>Siu, WK</contributor.author>
<contributor.author>Law, CY</contributor.author>
<contributor.author>Wong, CK</contributor.author>
<contributor.author>Lee, HK</contributor.author>
<contributor.author>Yeung, S</contributor.author>
<contributor.author>Sham, CO</contributor.author>
<contributor.author>Tse, K</contributor.author>
<contributor.author>Lee, HHC</contributor.author>
<contributor.author>Chen, SPL</contributor.author>
<contributor.author>Ching, CK</contributor.author>
<contributor.author>Au, CK</contributor.author>
<contributor.author>Poon, WT</contributor.author>
<contributor.author>Lam, CW</contributor.author>
<contributor.author>Kwong, NS</contributor.author>
<contributor.author>Chan, AYW</contributor.author>
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<description.abstract>AIM: Inborn errors of metabolism (IEM) are an unpopular and difficult subject and most clinicians are unfamiliar with them. Although chemical pathologists have a long-standing practice in advising test strategy and result interpretation especially from primary care, such consultations are usually informal, unstructured and those related to IEM are infrequently requested. This study aims to provide a formal electronic consultation service and to apply tandem mass spectrometry-based dried blood spot metabolic screening (DBSM) as a rapid first-line test for patients suspected of IEM. METHODS: DBSM and a chemical pathology consultation were ordered through the hospital computer terminals. DBSM detected 29 metabolic disorders. The clinical data and metabolic results for the 12-month period were reviewed. RESULTS: There were 279 consultations of which 209 were initiated by paediatricians and 70 by adult physicians. The main reasons for consultation were developmental delay, neurological abnormalities, unexplained biochemical abnormalities and monitoring of patients with IEM. There were 158 DBSM requests. One positive case of isovaleric acidaemia was detected. CONCLUSIONS: All high-risk paediatric patients should have a DBSM and a timely electronic chemical pathology consultation as a rapid and cost-effective first-line screening. Provision of a visible, accessible and helpful consultation service enables professional reimbursement.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. Princess Margaret Hospital Hong Kong
  3. Tuen Mun Hospital