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Article: Electronic chemical pathology consultation service and dried blood spot metabolic screening in hospital patients

TitleElectronic chemical pathology consultation service and dried blood spot metabolic screening in hospital patients
Authors
Issue Date2012
PublisherBMJ Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/
Citation
Journal of Clinical Pathology, 2012, v. 65 n. 12, p. 1141-1145 How to Cite?
AbstractAIM: Inborn errors of metabolism (IEM) are an unpopular and difficult subject and most clinicians are unfamiliar with them. Although chemical pathologists have a long-standing practice in advising test strategy and result interpretation especially from primary care, such consultations are usually informal, unstructured and those related to IEM are infrequently requested. This study aims to provide a formal electronic consultation service and to apply tandem mass spectrometry-based dried blood spot metabolic screening (DBSM) as a rapid first-line test for patients suspected of IEM. METHODS: DBSM and a chemical pathology consultation were ordered through the hospital computer terminals. DBSM detected 29 metabolic disorders. The clinical data and metabolic results for the 12-month period were reviewed. RESULTS: There were 279 consultations of which 209 were initiated by paediatricians and 70 by adult physicians. The main reasons for consultation were developmental delay, neurological abnormalities, unexplained biochemical abnormalities and monitoring of patients with IEM. There were 158 DBSM requests. One positive case of isovaleric acidaemia was detected. CONCLUSIONS: All high-risk paediatric patients should have a DBSM and a timely electronic chemical pathology consultation as a rapid and cost-effective first-line screening. Provision of a visible, accessible and helpful consultation service enables professional reimbursement.
Persistent Identifierhttp://hdl.handle.net/10722/164852
ISSN
2014 Impact Factor: 2.915
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMak, CMen_US
dc.contributor.authorSiu, WKen_US
dc.contributor.authorLaw, CYen_US
dc.contributor.authorWong, CKen_US
dc.contributor.authorLee, HKen_US
dc.contributor.authorYeung, Sen_US
dc.contributor.authorSham, COen_US
dc.contributor.authorTse, Ken_US
dc.contributor.authorLee, HHCen_US
dc.contributor.authorChen, SPLen_US
dc.contributor.authorChing, CKen_US
dc.contributor.authorAu, CKen_US
dc.contributor.authorPoon, WTen_US
dc.contributor.authorLam, CWen_US
dc.contributor.authorKwong, NSen_US
dc.contributor.authorChan, AYWen_US
dc.date.accessioned2012-09-20T08:11:00Z-
dc.date.available2012-09-20T08:11:00Z-
dc.date.issued2012en_US
dc.identifier.citationJournal of Clinical Pathology, 2012, v. 65 n. 12, p. 1141-1145en_US
dc.identifier.issn0021-9746-
dc.identifier.urihttp://hdl.handle.net/10722/164852-
dc.description.abstractAIM: Inborn errors of metabolism (IEM) are an unpopular and difficult subject and most clinicians are unfamiliar with them. Although chemical pathologists have a long-standing practice in advising test strategy and result interpretation especially from primary care, such consultations are usually informal, unstructured and those related to IEM are infrequently requested. This study aims to provide a formal electronic consultation service and to apply tandem mass spectrometry-based dried blood spot metabolic screening (DBSM) as a rapid first-line test for patients suspected of IEM. METHODS: DBSM and a chemical pathology consultation were ordered through the hospital computer terminals. DBSM detected 29 metabolic disorders. The clinical data and metabolic results for the 12-month period were reviewed. RESULTS: There were 279 consultations of which 209 were initiated by paediatricians and 70 by adult physicians. The main reasons for consultation were developmental delay, neurological abnormalities, unexplained biochemical abnormalities and monitoring of patients with IEM. There were 158 DBSM requests. One positive case of isovaleric acidaemia was detected. CONCLUSIONS: All high-risk paediatric patients should have a DBSM and a timely electronic chemical pathology consultation as a rapid and cost-effective first-line screening. Provision of a visible, accessible and helpful consultation service enables professional reimbursement.-
dc.languageengen_US
dc.publisherBMJ Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/-
dc.relation.ispartofJournal of Clinical Pathologyen_US
dc.rightsJournal of Clinical Pathology. Copyright © BMJ Publishing Group.-
dc.rightsThis article has been accepted for publication in [Journal of Clinical Pathology]. The definitive copyedited, typeset version [Journal of Clinical Pathology, 2012, v. 65 n. 12, p. 1141-1145] is available online at: www.jcp.bmj.com-
dc.titleElectronic chemical pathology consultation service and dried blood spot metabolic screening in hospital patientsen_US
dc.typeArticleen_US
dc.identifier.emailMak, CM: makm@ha.org.hken_US
dc.identifier.emailLaw, CY: ericlaw@pathology.hku.hken_US
dc.identifier.emailLam, CW: ching-wanlam@pathology.hku.hken_US
dc.identifier.authorityLaw, CY=rp01586en_US
dc.identifier.authorityLam, CW=rp00260en_US
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1136/jclinpath-2012-200837-
dc.identifier.pmid22888119-
dc.identifier.scopuseid_2-s2.0-84870067069-
dc.identifier.hkuros208493en_US
dc.identifier.hkuros222697-
dc.identifier.volume65-
dc.identifier.issue12-
dc.identifier.spage1141-
dc.identifier.epage1145-
dc.identifier.isiWOS:000311277700018-
dc.publisher.placeUnited Kingdom-

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