Article: Electronic chemical pathology consultation service and dried blood spot metabolic screening in hospital patients

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TitleElectronic chemical pathology consultation service and dried blood spot metabolic screening in hospital patients
AuthorsMak, CM2 3
Siu, WK2 3
Law, CY1 3
Wong, CK2
Lee, HK2
Yeung, S2
Sham, CO2
Tse, K2
Lee, HHC3
Chen, SPL3
Ching, CK3
Au, CK3
Poon, WT3
Lam, CW1
Kwong, NS2
Chan, AYW3
Issue Date2012
PublisherBMJ Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/
CitationJournal of Clinical Pathology, 2012, v. 65 n. 12, p. 1141-1145 [How to Cite?]
DOI: http://dx.doi.org/10.1136/jclinpath-2012-200837
AbstractAIM: Inborn errors of metabolism (IEM) are an unpopular and difficult subject and most clinicians are unfamiliar with them. Although chemical pathologists have a long-standing practice in advising test strategy and result interpretation especially from primary care, such consultations are usually informal, unstructured and those related to IEM are infrequently requested. This study aims to provide a formal electronic consultation service and to apply tandem mass spectrometry-based dried blood spot metabolic screening (DBSM) as a rapid first-line test for patients suspected of IEM. METHODS: DBSM and a chemical pathology consultation were ordered through the hospital computer terminals. DBSM detected 29 metabolic disorders. The clinical data and metabolic results for the 12-month period were reviewed. RESULTS: There were 279 consultations of which 209 were initiated by paediatricians and 70 by adult physicians. The main reasons for consultation were developmental delay, neurological abnormalities, unexplained biochemical abnormalities and monitoring of patients with IEM. There were 158 DBSM requests. One positive case of isovaleric acidaemia was detected. CONCLUSIONS: All high-risk paediatric patients should have a DBSM and a timely electronic chemical pathology consultation as a rapid and cost-effective first-line screening. Provision of a visible, accessible and helpful consultation service enables professional reimbursement.
ISSN0021-9746
2011 Impact Factor: 2.306
2011 SCImago Journal Rankings: 0.236
DOIhttp://dx.doi.org/10.1136/jclinpath-2012-200837
DC Field
Value
dc.contributor.authorMak, CM
dc.contributor.authorSiu, WK
dc.contributor.authorLaw, CY
dc.contributor.authorWong, CK
dc.contributor.authorLee, HK
dc.contributor.authorYeung, S
dc.contributor.authorSham, CO
dc.contributor.authorTse, K
dc.contributor.authorLee, HHC
dc.contributor.authorChen, SPL
dc.contributor.authorChing, CK
dc.contributor.authorAu, CK
dc.contributor.authorPoon, WT
dc.contributor.authorLam, CW
dc.contributor.authorKwong, NS
dc.contributor.authorChan, AYW
dc.date.accessioned2012-09-20T08:11:00Z
dc.date.available2012-09-20T08:11:00Z
dc.date.issued2012
dc.description.abstractAIM: Inborn errors of metabolism (IEM) are an unpopular and difficult subject and most clinicians are unfamiliar with them. Although chemical pathologists have a long-standing practice in advising test strategy and result interpretation especially from primary care, such consultations are usually informal, unstructured and those related to IEM are infrequently requested. This study aims to provide a formal electronic consultation service and to apply tandem mass spectrometry-based dried blood spot metabolic screening (DBSM) as a rapid first-line test for patients suspected of IEM. METHODS: DBSM and a chemical pathology consultation were ordered through the hospital computer terminals. DBSM detected 29 metabolic disorders. The clinical data and metabolic results for the 12-month period were reviewed. RESULTS: There were 279 consultations of which 209 were initiated by paediatricians and 70 by adult physicians. The main reasons for consultation were developmental delay, neurological abnormalities, unexplained biochemical abnormalities and monitoring of patients with IEM. There were 158 DBSM requests. One positive case of isovaleric acidaemia was detected. CONCLUSIONS: All high-risk paediatric patients should have a DBSM and a timely electronic chemical pathology consultation as a rapid and cost-effective first-line screening. Provision of a visible, accessible and helpful consultation service enables professional reimbursement.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationJournal of Clinical Pathology, 2012, v. 65 n. 12, p. 1141-1145 [How to Cite?]
DOI: http://dx.doi.org/10.1136/jclinpath-2012-200837
dc.identifier.doihttp://dx.doi.org/10.1136/jclinpath-2012-200837
dc.identifier.epage1145
dc.identifier.hkuros208493
dc.identifier.issn0021-9746
2011 Impact Factor: 2.306
2011 SCImago Journal Rankings: 0.236
dc.identifier.issue12
dc.identifier.pmid22888119
dc.identifier.scopuseid_2-s2.0-84870067069
dc.identifier.spage1141
dc.identifier.urihttp://hdl.handle.net/10722/164852
dc.identifier.volume65
dc.languageeng
dc.publisherBMJ Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/
dc.publisher.placeUnited Kingdom
dc.relation.ispartofJournal of Clinical Pathology
dc.rightsJournal of Clinical Pathology. Copyright © BMJ Publishing Group.
dc.rightsThis article has been accepted for publication in [Journal of Clinical Pathology]. The definitive copyedited, typeset version [Journal of Clinical Pathology, 2012, v. 65 n. 12, p. 1141-1145] is available online at: www.jcp.bmj.com
dc.titleElectronic chemical pathology consultation service and dried blood spot metabolic screening in hospital patients
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. Tuen Mun Hospital
  3. Princess Margaret Hospital Hong Kong