Article: Increased frequency of circulating follicular helper T cells in patients with rheumatoid arthritis

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TitleIncreased frequency of circulating follicular helper T cells in patients with rheumatoid arthritis
AuthorsMa, J1
Zhu, C1
Ma, B1
Tian, J1
Baidoo, SE1
Mao, C1
Wu, W1
Chen, J1
Tong, J1
Yang, M2
Jiao, Z1
Xu, H1
Lu, L2
Wang, S1
Issue Date2012
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/cdi/
CitationClinical & Developmental Immunology, 2012, v. 2012, article no. 827480 [How to Cite?]
DOI: http://dx.doi.org/10.1155/2012/827480
AbstractFollicular helper T (Tfh) cells are recognized as a distinct CD4(+) helper T-cell subset, which provides for B-cell activation and production of specific antibody responses, and play a critical role in the development of autoimmune disease. So far, only one study investigated the circulating Tfh cells increased in a subset of SLE patients. Since relatively little is known about the Tfh cells in rheumatoid arthritis (RA) patients, in this study, Tfh-cell frequency, related cytokine IL-21, and transcription factor Bcl-6 were investigated in 53 patients with RA and 31 health controls. Firstly, we found that the frequency of CD4(+)CXCR5(+)ICOS(high) Tfh cells was increased significantly in the peripheral blood of RA patients, compared with that in healthy controls. It is known that Tfh cells are critical for directing the development of an antibody response by germinal centers B cells; secondly, we observed that the Tfh-cell frequency is accompanied by the level of anti-CCP antibody in RA patients. Furthermore, expression of Bcl-6 mRNA and plasma IL-21 concentrations in RA patients was increased. Taken together, these findings have shown that the increased frequency of circulating Tfh cells is correlated with elevated levels of anti-CCP antibody, indicating the possible involvement of Tfh cells in the disease progression of RA.
ISSN1740-2522
2011 Impact Factor: 1.838
2011 SCImago Journal Rankings: 0.180
DOIhttp://dx.doi.org/10.1155/2012/827480
PubMed Central IDPMC3357937
DC Field
Value
dc.contributor.authorMa, J
dc.contributor.authorZhu, C
dc.contributor.authorMa, B
dc.contributor.authorTian, J
dc.contributor.authorBaidoo, SE
dc.contributor.authorMao, C
dc.contributor.authorWu, W
dc.contributor.authorChen, J
dc.contributor.authorTong, J
dc.contributor.authorYang, M
dc.contributor.authorJiao, Z
dc.contributor.authorXu, H
dc.contributor.authorLu, L
dc.contributor.authorWang, S
dc.date.accessioned2012-09-20T08:10:51Z
dc.date.available2012-09-20T08:10:51Z
dc.date.issued2012
dc.description.abstractFollicular helper T (Tfh) cells are recognized as a distinct CD4(+) helper T-cell subset, which provides for B-cell activation and production of specific antibody responses, and play a critical role in the development of autoimmune disease. So far, only one study investigated the circulating Tfh cells increased in a subset of SLE patients. Since relatively little is known about the Tfh cells in rheumatoid arthritis (RA) patients, in this study, Tfh-cell frequency, related cytokine IL-21, and transcription factor Bcl-6 were investigated in 53 patients with RA and 31 health controls. Firstly, we found that the frequency of CD4(+)CXCR5(+)ICOS(high) Tfh cells was increased significantly in the peripheral blood of RA patients, compared with that in healthy controls. It is known that Tfh cells are critical for directing the development of an antibody response by germinal centers B cells; secondly, we observed that the Tfh-cell frequency is accompanied by the level of anti-CCP antibody in RA patients. Furthermore, expression of Bcl-6 mRNA and plasma IL-21 concentrations in RA patients was increased. Taken together, these findings have shown that the increased frequency of circulating Tfh cells is correlated with elevated levels of anti-CCP antibody, indicating the possible involvement of Tfh cells in the disease progression of RA.
dc.description.naturepublished_or_final_version
dc.identifier.citationClinical & Developmental Immunology, 2012, v. 2012, article no. 827480 [How to Cite?]
DOI: http://dx.doi.org/10.1155/2012/827480
dc.identifier.doihttp://dx.doi.org/10.1155/2012/827480
dc.identifier.hkuros208184
dc.identifier.issn1740-2522
2011 Impact Factor: 1.838
2011 SCImago Journal Rankings: 0.180
dc.identifier.openurl
dc.identifier.pmcidPMC3357937
dc.identifier.pmid22649468
dc.identifier.scopuseid_2-s2.0-84862298255
dc.identifier.urihttp://hdl.handle.net/10722/164845
dc.identifier.volume2012, article no. 827480
dc.languageeng
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/cdi/
dc.publisher.placeUnited States
dc.relation.ispartofClinical & Developmental Immunology
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
dc.subject.meshArthritis, Rheumatoid - diagnosis - immunology
dc.subject.meshDNA-Binding Proteins - genetics - immunology - metabolism
dc.subject.meshInducible T-Cell Co-Stimulator Protein - metabolism
dc.subject.meshInterleukins - biosynthesis - blood - genetics
dc.subject.meshT-Lymphocytes, Helper-Inducer - immunology
dc.titleIncreased frequency of circulating follicular helper T cells in patients with rheumatoid arthritis
dc.typeArticle
Author Affiliations
  1. Jiangsu University
  2. The University of Hong Kong