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Article: Increased frequency of circulating follicular helper T cells in patients with rheumatoid arthritis

TitleIncreased frequency of circulating follicular helper T cells in patients with rheumatoid arthritis
Authors
Issue Date2012
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/cdi/
Citation
Clinical & Developmental Immunology, 2012, v. 2012, article no. 827480 How to Cite?
AbstractFollicular helper T (Tfh) cells are recognized as a distinct CD4(+) helper T-cell subset, which provides for B-cell activation and production of specific antibody responses, and play a critical role in the development of autoimmune disease. So far, only one study investigated the circulating Tfh cells increased in a subset of SLE patients. Since relatively little is known about the Tfh cells in rheumatoid arthritis (RA) patients, in this study, Tfh-cell frequency, related cytokine IL-21, and transcription factor Bcl-6 were investigated in 53 patients with RA and 31 health controls. Firstly, we found that the frequency of CD4(+)CXCR5(+)ICOS(high) Tfh cells was increased significantly in the peripheral blood of RA patients, compared with that in healthy controls. It is known that Tfh cells are critical for directing the development of an antibody response by germinal centers B cells; secondly, we observed that the Tfh-cell frequency is accompanied by the level of anti-CCP antibody in RA patients. Furthermore, expression of Bcl-6 mRNA and plasma IL-21 concentrations in RA patients was increased. Taken together, these findings have shown that the increased frequency of circulating Tfh cells is correlated with elevated levels of anti-CCP antibody, indicating the possible involvement of Tfh cells in the disease progression of RA.
Persistent Identifierhttp://hdl.handle.net/10722/164845
ISSN
2014 Impact Factor: 2.934
2013 SCImago Journal Rankings: 1.186
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMa, Jen_US
dc.contributor.authorZhu, Cen_US
dc.contributor.authorMa, Ben_US
dc.contributor.authorTian, Jen_US
dc.contributor.authorBaidoo, SEen_US
dc.contributor.authorMao, Cen_US
dc.contributor.authorWu, Wen_US
dc.contributor.authorChen, Jen_US
dc.contributor.authorTong, Jen_US
dc.contributor.authorYang, Men_US
dc.contributor.authorJiao, Zen_US
dc.contributor.authorXu, Hen_US
dc.contributor.authorLu, Len_US
dc.contributor.authorWang, Sen_US
dc.date.accessioned2012-09-20T08:10:51Z-
dc.date.available2012-09-20T08:10:51Z-
dc.date.issued2012en_US
dc.identifier.citationClinical & Developmental Immunology, 2012, v. 2012, article no. 827480en_US
dc.identifier.issn1740-2522en_US
dc.identifier.urihttp://hdl.handle.net/10722/164845-
dc.description.abstractFollicular helper T (Tfh) cells are recognized as a distinct CD4(+) helper T-cell subset, which provides for B-cell activation and production of specific antibody responses, and play a critical role in the development of autoimmune disease. So far, only one study investigated the circulating Tfh cells increased in a subset of SLE patients. Since relatively little is known about the Tfh cells in rheumatoid arthritis (RA) patients, in this study, Tfh-cell frequency, related cytokine IL-21, and transcription factor Bcl-6 were investigated in 53 patients with RA and 31 health controls. Firstly, we found that the frequency of CD4(+)CXCR5(+)ICOS(high) Tfh cells was increased significantly in the peripheral blood of RA patients, compared with that in healthy controls. It is known that Tfh cells are critical for directing the development of an antibody response by germinal centers B cells; secondly, we observed that the Tfh-cell frequency is accompanied by the level of anti-CCP antibody in RA patients. Furthermore, expression of Bcl-6 mRNA and plasma IL-21 concentrations in RA patients was increased. Taken together, these findings have shown that the increased frequency of circulating Tfh cells is correlated with elevated levels of anti-CCP antibody, indicating the possible involvement of Tfh cells in the disease progression of RA.-
dc.languageengen_US
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/cdi/-
dc.relation.ispartofClinical & Developmental Immunologyen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshArthritis, Rheumatoid - diagnosis - immunology-
dc.subject.meshDNA-Binding Proteins - genetics - immunology - metabolism-
dc.subject.meshInducible T-Cell Co-Stimulator Protein - metabolism-
dc.subject.meshInterleukins - biosynthesis - blood - genetics-
dc.subject.meshT-Lymphocytes, Helper-Inducer - immunology-
dc.titleIncreased frequency of circulating follicular helper T cells in patients with rheumatoid arthritisen_US
dc.typeArticleen_US
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1740-2530 (Electronic) 1740-2522 (Linkin&volume=2012&spage=827480&epage=&date=2012&atitle=Increased+frequency+of+circulating+follicular+helper+T+cells+in+patients+with+rheumatoid+arthritisen_US
dc.identifier.emailLu, L: liweilu@hkucc.hku.hken_US
dc.identifier.emailWang, S: sjwjs@ujs.edu.cn-
dc.identifier.authorityLu, L=rp00477en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1155/2012/827480-
dc.identifier.pmid22649468-
dc.identifier.pmcidPMC3357937-
dc.identifier.scopuseid_2-s2.0-84862298255-
dc.identifier.hkuros208184en_US
dc.identifier.volume2012, article no. 827480en_US
dc.identifier.isiWOS:000305021000001-
dc.publisher.placeUnited States-

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