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Article: Increased frequency of circulating follicular helper T cells in patients with rheumatoid arthritis
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TitleIncreased frequency of circulating follicular helper T cells in patients with rheumatoid arthritis
 
AuthorsMa, J1
Zhu, C1
Ma, B1
Tian, J1
Baidoo, SE1
Mao, C1
Wu, W1
Chen, J1
Tong, J1
Yang, M2
Jiao, Z1
Xu, H1
Lu, L2
Wang, S1
 
Issue Date2012
 
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/cdi/
 
CitationClinical & Developmental Immunology, 2012, v. 2012, article no. 827480 [How to Cite?]
DOI: http://dx.doi.org/10.1155/2012/827480
 
AbstractFollicular helper T (Tfh) cells are recognized as a distinct CD4(+) helper T-cell subset, which provides for B-cell activation and production of specific antibody responses, and play a critical role in the development of autoimmune disease. So far, only one study investigated the circulating Tfh cells increased in a subset of SLE patients. Since relatively little is known about the Tfh cells in rheumatoid arthritis (RA) patients, in this study, Tfh-cell frequency, related cytokine IL-21, and transcription factor Bcl-6 were investigated in 53 patients with RA and 31 health controls. Firstly, we found that the frequency of CD4(+)CXCR5(+)ICOS(high) Tfh cells was increased significantly in the peripheral blood of RA patients, compared with that in healthy controls. It is known that Tfh cells are critical for directing the development of an antibody response by germinal centers B cells; secondly, we observed that the Tfh-cell frequency is accompanied by the level of anti-CCP antibody in RA patients. Furthermore, expression of Bcl-6 mRNA and plasma IL-21 concentrations in RA patients was increased. Taken together, these findings have shown that the increased frequency of circulating Tfh cells is correlated with elevated levels of anti-CCP antibody, indicating the possible involvement of Tfh cells in the disease progression of RA.
 
ISSN1740-2522
2013 Impact Factor: 2.934
 
DOIhttp://dx.doi.org/10.1155/2012/827480
 
PubMed Central IDPMC3357937
 
ISI Accession Number IDWOS:000305021000001
 
DC FieldValue
dc.contributor.authorMa, J
 
dc.contributor.authorZhu, C
 
dc.contributor.authorMa, B
 
dc.contributor.authorTian, J
 
dc.contributor.authorBaidoo, SE
 
dc.contributor.authorMao, C
 
dc.contributor.authorWu, W
 
dc.contributor.authorChen, J
 
dc.contributor.authorTong, J
 
dc.contributor.authorYang, M
 
dc.contributor.authorJiao, Z
 
dc.contributor.authorXu, H
 
dc.contributor.authorLu, L
 
dc.contributor.authorWang, S
 
dc.date.accessioned2012-09-20T08:10:51Z
 
dc.date.available2012-09-20T08:10:51Z
 
dc.date.issued2012
 
dc.description.abstractFollicular helper T (Tfh) cells are recognized as a distinct CD4(+) helper T-cell subset, which provides for B-cell activation and production of specific antibody responses, and play a critical role in the development of autoimmune disease. So far, only one study investigated the circulating Tfh cells increased in a subset of SLE patients. Since relatively little is known about the Tfh cells in rheumatoid arthritis (RA) patients, in this study, Tfh-cell frequency, related cytokine IL-21, and transcription factor Bcl-6 were investigated in 53 patients with RA and 31 health controls. Firstly, we found that the frequency of CD4(+)CXCR5(+)ICOS(high) Tfh cells was increased significantly in the peripheral blood of RA patients, compared with that in healthy controls. It is known that Tfh cells are critical for directing the development of an antibody response by germinal centers B cells; secondly, we observed that the Tfh-cell frequency is accompanied by the level of anti-CCP antibody in RA patients. Furthermore, expression of Bcl-6 mRNA and plasma IL-21 concentrations in RA patients was increased. Taken together, these findings have shown that the increased frequency of circulating Tfh cells is correlated with elevated levels of anti-CCP antibody, indicating the possible involvement of Tfh cells in the disease progression of RA.
 
dc.description.naturepublished_or_final_version
 
dc.identifier.citationClinical & Developmental Immunology, 2012, v. 2012, article no. 827480 [How to Cite?]
DOI: http://dx.doi.org/10.1155/2012/827480
 
dc.identifier.doihttp://dx.doi.org/10.1155/2012/827480
 
dc.identifier.hkuros208184
 
dc.identifier.isiWOS:000305021000001
 
dc.identifier.issn1740-2522
2013 Impact Factor: 2.934
 
dc.identifier.openurl
 
dc.identifier.pmcidPMC3357937
 
dc.identifier.pmid22649468
 
dc.identifier.scopuseid_2-s2.0-84862298255
 
dc.identifier.urihttp://hdl.handle.net/10722/164845
 
dc.identifier.volume2012, article no. 827480
 
dc.languageeng
 
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/cdi/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofClinical & Developmental Immunology
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshArthritis, Rheumatoid - diagnosis - immunology
 
dc.subject.meshDNA-Binding Proteins - genetics - immunology - metabolism
 
dc.subject.meshInducible T-Cell Co-Stimulator Protein - metabolism
 
dc.subject.meshInterleukins - biosynthesis - blood - genetics
 
dc.subject.meshT-Lymphocytes, Helper-Inducer - immunology
 
dc.titleIncreased frequency of circulating follicular helper T cells in patients with rheumatoid arthritis
 
dc.typeArticle
 
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<contributor.author>Zhu, C</contributor.author>
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<contributor.author>Tian, J</contributor.author>
<contributor.author>Baidoo, SE</contributor.author>
<contributor.author>Mao, C</contributor.author>
<contributor.author>Wu, W</contributor.author>
<contributor.author>Chen, J</contributor.author>
<contributor.author>Tong, J</contributor.author>
<contributor.author>Yang, M</contributor.author>
<contributor.author>Jiao, Z</contributor.author>
<contributor.author>Xu, H</contributor.author>
<contributor.author>Lu, L</contributor.author>
<contributor.author>Wang, S</contributor.author>
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<description.abstract>Follicular helper T (Tfh) cells are recognized as a distinct CD4(+) helper T-cell subset, which provides for B-cell activation and production of specific antibody responses, and play a critical role in the development of autoimmune disease. So far, only one study investigated the circulating Tfh cells increased in a subset of SLE patients. Since relatively little is known about the Tfh cells in rheumatoid arthritis (RA) patients, in this study, Tfh-cell frequency, related cytokine IL-21, and transcription factor Bcl-6 were investigated in 53 patients with RA and 31 health controls. Firstly, we found that the frequency of CD4(+)CXCR5(+)ICOS(high) Tfh cells was increased significantly in the peripheral blood of RA patients, compared with that in healthy controls. It is known that Tfh cells are critical for directing the development of an antibody response by germinal centers B cells; secondly, we observed that the Tfh-cell frequency is accompanied by the level of anti-CCP antibody in RA patients. Furthermore, expression of Bcl-6 mRNA and plasma IL-21 concentrations in RA patients was increased. Taken together, these findings have shown that the increased frequency of circulating Tfh cells is correlated with elevated levels of anti-CCP antibody, indicating the possible involvement of Tfh cells in the disease progression of RA.</description.abstract>
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Author Affiliations
  1. Jiangsu University
  2. The University of Hong Kong