Article: Obstructive lung disease does not increase lung cancer mortality among female never-smokers in Hong Kong

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TitleObstructive lung disease does not increase lung cancer mortality among female never-smokers in Hong Kong
AuthorsLeung, CC2
Lam, TH1
Yew, WW3
Law, WS2
Tam, CM2
Chang, KC2
McGhee, S2
Tam, SY2
Chan, KF2
Issue Date2012
PublisherInternational Union against Tuberculosis and Lung Disease. The Journal's web site is located at http://www.theunion.org/about-the-journal/about-the-journal.html
CitationInternational Journal of Tuberculosis and Lung Disease, 2012, v. 16 n. 4, p. 546-552 [How to Cite?]
DOI: http://dx.doi.org/10.5588/ijtld.11.0573
AbstractSETTING: High lung cancer mortality is observed among female never-smokers in Hong Kong. OBJECTIVE: To examine the relationship between obstructive lung disease (chronic obstructive pulmonary disease and/or asthma) and lung cancer mortality by sex and smoking status. DESIGN: A cohort of elderly clients (aged >/=65 years) in a health maintenance programme were followed prospectively through linkage with the territory-wide death registry for causes of death, using identity card number as the unique identifier. RESULTS: After 516,055 person-years of follow-up, respectively 1297, 872 and 1908 deaths were caused by lung cancer, other tobacco-related malignancies and non-tobacco-related malignancies. In the overall analysis, obstructive lung disease was independently associated with mortality due to lung cancer (aHR 1.86, P < 0.001) after adjustment for potential confounders. However, no association was detected among female never-smokers (HR 0.97, P = 0.909), in sharp contrast with female ever-smokers, male never-smokers and male ever-smokers (HR 1.98, 2.34 and 2.09, respectively, P from 0.047 to <0.001). Consistent results were observed after exclusion of all deaths in the initial 3 years. CONCLUSION: Obstructive lung disease exerted differential effects on lung cancer mortality across different sex and smoking subgroups in this Asian population, with a conspicuous absence of effect among female never-smokers.
DescriptionDOI: Free content
ISSN1027-3719
2011 Impact Factor: 2.731
2011 SCImago Journal Rankings: 0.249
DOIhttp://dx.doi.org/10.5588/ijtld.11.0573
DC Field
Value
dc.contributor.authorLeung, CC
dc.contributor.authorLam, TH
dc.contributor.authorYew, WW
dc.contributor.authorLaw, WS
dc.contributor.authorTam, CM
dc.contributor.authorChang, KC
dc.contributor.authorMcGhee, S
dc.contributor.authorTam, SY
dc.contributor.authorChan, KF
dc.date.accessioned2012-09-20T08:09:39Z
dc.date.available2012-09-20T08:09:39Z
dc.date.issued2012
dc.description.abstractSETTING: High lung cancer mortality is observed among female never-smokers in Hong Kong. OBJECTIVE: To examine the relationship between obstructive lung disease (chronic obstructive pulmonary disease and/or asthma) and lung cancer mortality by sex and smoking status. DESIGN: A cohort of elderly clients (aged >/=65 years) in a health maintenance programme were followed prospectively through linkage with the territory-wide death registry for causes of death, using identity card number as the unique identifier. RESULTS: After 516,055 person-years of follow-up, respectively 1297, 872 and 1908 deaths were caused by lung cancer, other tobacco-related malignancies and non-tobacco-related malignancies. In the overall analysis, obstructive lung disease was independently associated with mortality due to lung cancer (aHR 1.86, P < 0.001) after adjustment for potential confounders. However, no association was detected among female never-smokers (HR 0.97, P = 0.909), in sharp contrast with female ever-smokers, male never-smokers and male ever-smokers (HR 1.98, 2.34 and 2.09, respectively, P from 0.047 to <0.001). Consistent results were observed after exclusion of all deaths in the initial 3 years. CONCLUSION: Obstructive lung disease exerted differential effects on lung cancer mortality across different sex and smoking subgroups in this Asian population, with a conspicuous absence of effect among female never-smokers.
dc.description.natureLink_to_subscribed_fulltext
dc.descriptionDOI: Free content
dc.identifier.citationInternational Journal of Tuberculosis and Lung Disease, 2012, v. 16 n. 4, p. 546-552 [How to Cite?]
DOI: http://dx.doi.org/10.5588/ijtld.11.0573
dc.identifier.doihttp://dx.doi.org/10.5588/ijtld.11.0573
dc.identifier.epage552
dc.identifier.hkuros206458
dc.identifier.issn1027-3719
2011 Impact Factor: 2.731
2011 SCImago Journal Rankings: 0.249
dc.identifier.issue4
dc.identifier.pmid22325953
dc.identifier.scopuseid_2-s2.0-84858634454
dc.identifier.spage546
dc.identifier.urihttp://hdl.handle.net/10722/164793
dc.identifier.volume16
dc.languageeng
dc.publisherInternational Union against Tuberculosis and Lung Disease. The Journal's web site is located at http://www.theunion.org/about-the-journal/about-the-journal.html
dc.publisher.placeFrance
dc.relation.ispartofInternational Journal of Tuberculosis and Lung Disease
dc.rightsInternational Journal of Tuberculosis and Lung Disease. Copyright © International Union against Tuberculosis and Lung Disease.
dc.subject.meshAsian Continental Ancestry Group - statistics and numerical data
dc.subject.meshAsthma - complications
dc.subject.meshLung Neoplasms - etiology - mortality
dc.subject.meshPulmonary Disease, Chronic Obstructive - complications
dc.subject.meshSmoking - adverse effects - epidemiology
dc.titleObstructive lung disease does not increase lung cancer mortality among female never-smokers in Hong Kong
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. TB and Chest Service
  3. Grantham Hospital Hong Kong