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Article: Obstructive lung disease does not increase lung cancer mortality among female never-smokers in Hong Kong

TitleObstructive lung disease does not increase lung cancer mortality among female never-smokers in Hong Kong
Authors
Issue Date2012
PublisherInternational Union against Tuberculosis and Lung Disease. The Journal's web site is located at http://www.theunion.org/about-the-journal/about-the-journal.html
Citation
International Journal of Tuberculosis and Lung Disease, 2012, v. 16 n. 4, p. 546-552 How to Cite?
AbstractSETTING: High lung cancer mortality is observed among female never-smokers in Hong Kong. OBJECTIVE: To examine the relationship between obstructive lung disease (chronic obstructive pulmonary disease and/or asthma) and lung cancer mortality by sex and smoking status. DESIGN: A cohort of elderly clients (aged >/=65 years) in a health maintenance programme were followed prospectively through linkage with the territory-wide death registry for causes of death, using identity card number as the unique identifier. RESULTS: After 516,055 person-years of follow-up, respectively 1297, 872 and 1908 deaths were caused by lung cancer, other tobacco-related malignancies and non-tobacco-related malignancies. In the overall analysis, obstructive lung disease was independently associated with mortality due to lung cancer (aHR 1.86, P < 0.001) after adjustment for potential confounders. However, no association was detected among female never-smokers (HR 0.97, P = 0.909), in sharp contrast with female ever-smokers, male never-smokers and male ever-smokers (HR 1.98, 2.34 and 2.09, respectively, P from 0.047 to <0.001). Consistent results were observed after exclusion of all deaths in the initial 3 years. CONCLUSION: Obstructive lung disease exerted differential effects on lung cancer mortality across different sex and smoking subgroups in this Asian population, with a conspicuous absence of effect among female never-smokers.
Persistent Identifierhttp://hdl.handle.net/10722/164793
ISSN
2015 Impact Factor: 2.148
2015 SCImago Journal Rankings: 1.381
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLeung, CCen_US
dc.contributor.authorLam, THen_US
dc.contributor.authorYew, WWen_US
dc.contributor.authorLaw, WSen_US
dc.contributor.authorTam, CMen_US
dc.contributor.authorChang, KCen_US
dc.contributor.authorMcGhee, Sen_US
dc.contributor.authorTam, SYen_US
dc.contributor.authorChan, KFen_US
dc.date.accessioned2012-09-20T08:09:39Z-
dc.date.available2012-09-20T08:09:39Z-
dc.date.issued2012en_US
dc.identifier.citationInternational Journal of Tuberculosis and Lung Disease, 2012, v. 16 n. 4, p. 546-552en_US
dc.identifier.issn1027-3719-
dc.identifier.urihttp://hdl.handle.net/10722/164793-
dc.description.abstractSETTING: High lung cancer mortality is observed among female never-smokers in Hong Kong. OBJECTIVE: To examine the relationship between obstructive lung disease (chronic obstructive pulmonary disease and/or asthma) and lung cancer mortality by sex and smoking status. DESIGN: A cohort of elderly clients (aged >/=65 years) in a health maintenance programme were followed prospectively through linkage with the territory-wide death registry for causes of death, using identity card number as the unique identifier. RESULTS: After 516,055 person-years of follow-up, respectively 1297, 872 and 1908 deaths were caused by lung cancer, other tobacco-related malignancies and non-tobacco-related malignancies. In the overall analysis, obstructive lung disease was independently associated with mortality due to lung cancer (aHR 1.86, P < 0.001) after adjustment for potential confounders. However, no association was detected among female never-smokers (HR 0.97, P = 0.909), in sharp contrast with female ever-smokers, male never-smokers and male ever-smokers (HR 1.98, 2.34 and 2.09, respectively, P from 0.047 to <0.001). Consistent results were observed after exclusion of all deaths in the initial 3 years. CONCLUSION: Obstructive lung disease exerted differential effects on lung cancer mortality across different sex and smoking subgroups in this Asian population, with a conspicuous absence of effect among female never-smokers.-
dc.languageengen_US
dc.publisherInternational Union against Tuberculosis and Lung Disease. The Journal's web site is located at http://www.theunion.org/about-the-journal/about-the-journal.html-
dc.relation.ispartofInternational Journal of Tuberculosis and Lung Diseaseen_US
dc.rightsInternational Journal of Tuberculosis and Lung Disease. Copyright © International Union against Tuberculosis and Lung Disease.-
dc.subject.meshAsian Continental Ancestry Group - statistics and numerical data-
dc.subject.meshAsthma - complications-
dc.subject.meshLung Neoplasms - etiology - mortality-
dc.subject.meshPulmonary Disease, Chronic Obstructive - complications-
dc.subject.meshSmoking - adverse effects - epidemiology-
dc.titleObstructive lung disease does not increase lung cancer mortality among female never-smokers in Hong Kongen_US
dc.typeArticleen_US
dc.identifier.emailLam, TH: hrmrlth@hkucc.hku.hken_US
dc.identifier.emailMcGhee, S: smmcghee@hkucc.hku.hken_US
dc.identifier.authorityLam, TH=rp00326en_US
dc.identifier.authorityMcGhee, S=rp00393en_US
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.5588/ijtld.11.0573-
dc.identifier.pmid22325953-
dc.identifier.scopuseid_2-s2.0-84858634454-
dc.identifier.hkuros206458en_US
dc.identifier.volume16en_US
dc.identifier.issue4en_US
dc.identifier.spage546en_US
dc.identifier.epage552en_US
dc.identifier.isiWOS:000302336300022-
dc.publisher.placeFrance-

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