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Article: Genomewide association scan of suicidal thoughts and behaviour in major depression

TitleGenomewide association scan of suicidal thoughts and behaviour in major depression
Authors
Issue Date2011
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
PLoS One, 2011, v. 6 n. 7, article no. e20690 How to Cite?
AbstractBACKGROUND: Suicidal behaviour can be conceptualised as a continuum from suicidal ideation, to suicidal attempts to completed suicide. In this study we identify genes contributing to suicidal behaviour in the depression study RADIANT. METHODOLOGY/PRINCIPAL FINDINGS: A quantitative suicidality score was composed of two items from the SCAN interview. In addition, the 251 depression cases with a history of serious suicide attempts were classified to form a discrete trait. The quantitative trait was correlated with younger onset of depression and number of episodes of depression, but not with gender. A genome-wide association study of 2,023 depression cases was performed to identify genes that may contribute to suicidal behaviour. Two Munich depression studies were used as replication cohorts to test the most strongly associated SNPs. No SNP was associated at genome-wide significance level. For the quantitative trait, evidence of association was detected at GFRA1, a receptor for the neurotrophin GDRA (p = 2e-06). For the discrete trait of suicide attempt, SNPs in KIAA1244 and RGS18 attained p-values of <5e-6. None of these SNPs showed evidence for replication in the additional cohorts tested. Candidate gene analysis provided some support for a polymorphism in NTRK2, which was previously associated with suicidality. CONCLUSIONS/SIGNIFICANCE: This study provides a genome-wide assessment of possible genetic contribution to suicidal behaviour in depression but indicates a genetic architecture of multiple genes with small effects. Large cohorts will be required to dissect this further.
Persistent Identifierhttp://hdl.handle.net/10722/164567
ISSN
2015 Impact Factor: 3.057
2015 SCImago Journal Rankings: 1.395
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSchosser, Aen_US
dc.contributor.authorButler, AWen_US
dc.contributor.authorIsing, Men_US
dc.contributor.authorPerroud, Nen_US
dc.contributor.authorUher, R-
dc.contributor.authorNg, MY-
dc.contributor.authorCohen-Woods, S-
dc.contributor.authorCraddock, N-
dc.contributor.authorOwen, MJ-
dc.contributor.authorKorszun, A-
dc.contributor.authorJones, L-
dc.contributor.authorJones, I-
dc.contributor.authorGill, M-
dc.contributor.authorRice, JP-
dc.contributor.authorMaier, W-
dc.contributor.authorMors, O-
dc.contributor.authorRietschel, M-
dc.contributor.authorLucae, S-
dc.contributor.authorBinder, EB-
dc.contributor.authorPreisig, M-
dc.contributor.authorPerry, J-
dc.contributor.authorTozzi, F-
dc.contributor.authorMuglia, P-
dc.contributor.authorAitchison, KJ-
dc.contributor.authorBreen, G-
dc.contributor.authorCraig, IW-
dc.contributor.authorFarmer, AE-
dc.contributor.authorMulller-Myhsok, B-
dc.contributor.authorMcGuffin, P-
dc.contributor.authorLewis, CM-
dc.date.accessioned2012-09-20T08:06:04Z-
dc.date.available2012-09-20T08:06:04Z-
dc.date.issued2011en_US
dc.identifier.citationPLoS One, 2011, v. 6 n. 7, article no. e20690en_US
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/10722/164567-
dc.description.abstractBACKGROUND: Suicidal behaviour can be conceptualised as a continuum from suicidal ideation, to suicidal attempts to completed suicide. In this study we identify genes contributing to suicidal behaviour in the depression study RADIANT. METHODOLOGY/PRINCIPAL FINDINGS: A quantitative suicidality score was composed of two items from the SCAN interview. In addition, the 251 depression cases with a history of serious suicide attempts were classified to form a discrete trait. The quantitative trait was correlated with younger onset of depression and number of episodes of depression, but not with gender. A genome-wide association study of 2,023 depression cases was performed to identify genes that may contribute to suicidal behaviour. Two Munich depression studies were used as replication cohorts to test the most strongly associated SNPs. No SNP was associated at genome-wide significance level. For the quantitative trait, evidence of association was detected at GFRA1, a receptor for the neurotrophin GDRA (p = 2e-06). For the discrete trait of suicide attempt, SNPs in KIAA1244 and RGS18 attained p-values of <5e-6. None of these SNPs showed evidence for replication in the additional cohorts tested. Candidate gene analysis provided some support for a polymorphism in NTRK2, which was previously associated with suicidality. CONCLUSIONS/SIGNIFICANCE: This study provides a genome-wide assessment of possible genetic contribution to suicidal behaviour in depression but indicates a genetic architecture of multiple genes with small effects. Large cohorts will be required to dissect this further.-
dc.languageengen_US
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action-
dc.relation.ispartofPLoS Oneen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAlleles-
dc.subject.meshDepressive Disorder, Major - genetics - psychology-
dc.subject.meshGenome-Wide Association Study - methods-
dc.subject.meshSuicidal Ideation-
dc.subject.meshSuicide, Attempted-
dc.titleGenomewide association scan of suicidal thoughts and behaviour in major depressionen_US
dc.typeArticleen_US
dc.identifier.emailButler, AW: wbutler@hku.hken_US
dc.identifier.emailLewis, CM: Cathryn.lewis@kcl.ac.uk-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0020690-
dc.identifier.pmid21750702-
dc.identifier.pmcidPMC3130038-
dc.identifier.scopuseid_2-s2.0-79959981469-
dc.identifier.hkuros210464en_US
dc.identifier.volume6-
dc.identifier.issue7, article no. e20690-
dc.identifier.isiWOS:000292512000008-
dc.publisher.placeUnited States-
dc.identifier.citeulike9595180-

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