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Article: Biological treatment for intervertebral disc degeneration to preserve motion - reality or fantasy?

TitleBiological treatment for intervertebral disc degeneration to preserve motion - reality or fantasy?
Authors
KeywordsBiological therapeutics
Gene therapy
Growth factors
Intervertebral disc degeneration
Mesenchymal stem cell therapy
Regenerative medicine
Stem cell therapy
Issue Date2012
PublisherTouch Briefings. The Journal's web site is located at http://www.touchbriefings.com/musculoskeletal.htm
Citation
European Musculoskeletal Review, 2012, v. 7 n. 1, p. 49-53 How to Cite?
AbstractIntervertebral disc (IVD) degeneration and its associated low back pain affects a large proportion of the worldwide population and is characterised by biochemical changes in the IVD, such as loss of proteoglycans and water, which leads to structural and functional changes of the IVD. The majority of conventional treatments for IVD degeneration aim to reduce the clinical symptoms associated with this condition, yet few commonly used treatments address the underlying biological causes of IVD degeneration. Recently, there has been an increase in the study of biological therapeutics to counter IVD degeneration. The rationale behind this is that by addressing the underlying biological causes of IVD degeneration, the structure, integrity and function of the degenerated IVD could improve. Several approaches including that of the application of growth factors, gene therapy and cellular therapy have been taken and we review here the latest updates in their potential as treatments for IVD degeneration. © TOUCH BRIEFINGS 2012.
Persistent Identifierhttp://hdl.handle.net/10722/164451
ISSN
2015 SCImago Journal Rankings: 0.137
References

 

DC FieldValueLanguage
dc.contributor.authorTam, Ven_HK
dc.contributor.authorLeung, Ven_HK
dc.contributor.authorCheung, KMCen_HK
dc.date.accessioned2012-09-20T07:59:38Z-
dc.date.available2012-09-20T07:59:38Z-
dc.date.issued2012en_HK
dc.identifier.citationEuropean Musculoskeletal Review, 2012, v. 7 n. 1, p. 49-53en_HK
dc.identifier.issn1754-5072en_HK
dc.identifier.urihttp://hdl.handle.net/10722/164451-
dc.description.abstractIntervertebral disc (IVD) degeneration and its associated low back pain affects a large proportion of the worldwide population and is characterised by biochemical changes in the IVD, such as loss of proteoglycans and water, which leads to structural and functional changes of the IVD. The majority of conventional treatments for IVD degeneration aim to reduce the clinical symptoms associated with this condition, yet few commonly used treatments address the underlying biological causes of IVD degeneration. Recently, there has been an increase in the study of biological therapeutics to counter IVD degeneration. The rationale behind this is that by addressing the underlying biological causes of IVD degeneration, the structure, integrity and function of the degenerated IVD could improve. Several approaches including that of the application of growth factors, gene therapy and cellular therapy have been taken and we review here the latest updates in their potential as treatments for IVD degeneration. © TOUCH BRIEFINGS 2012.en_HK
dc.languageengen_US
dc.publisherTouch Briefings. The Journal's web site is located at http://www.touchbriefings.com/musculoskeletal.htmen_HK
dc.relation.ispartofEuropean Musculoskeletal Reviewen_HK
dc.subjectBiological therapeuticsen_HK
dc.subjectGene therapyen_HK
dc.subjectGrowth factorsen_HK
dc.subjectIntervertebral disc degenerationen_HK
dc.subjectMesenchymal stem cell therapyen_HK
dc.subjectRegenerative medicineen_HK
dc.subjectStem cell therapyen_HK
dc.titleBiological treatment for intervertebral disc degeneration to preserve motion - reality or fantasy?en_HK
dc.typeArticleen_HK
dc.identifier.emailLeung, V: vicleung@hku.hken_HK
dc.identifier.emailCheung, KMC: cheungmc@hku.hken_HK
dc.identifier.authorityLeung, V=rp01764en_HK
dc.identifier.authorityCheung, KMC=rp00387en_HK
dc.identifier.scopuseid_2-s2.0-84866761935en_HK
dc.identifier.hkuros210234en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84866761935&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7en_HK
dc.identifier.issue1en_HK
dc.identifier.spage49en_HK
dc.identifier.epage53en_HK
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridTam, V=35977084900en_HK
dc.identifier.scopusauthoridLeung, V=35337438900en_HK
dc.identifier.scopusauthoridCheung, KMC=7402406754en_HK

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