File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Sudden cardiac death after myocardial infarction in type 2 diabetic patients with no residual myocardial ischemia

TitleSudden cardiac death after myocardial infarction in type 2 diabetic patients with no residual myocardial ischemia
Authors
Issue Date2012
PublisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/
Citation
Diabetes Care, 2012, v. 35 n. 12, p. 2564-2569 How to Cite?
Abstract
OBJECTIVE Diabetes mellitus (DM) is a well-established risk factor for coronary artery disease. Nonetheless, it remains unclear whether DM contributes to sudden cardiac death in patients who survive myocardial infarction (MI). The objective of this study was to compare the incidence of sudden cardiac death post-MI in diabetic and nondiabetic patients with no residual myocardial ischemia. RESEARCH DESIGN AND METHODS A total of 610 consecutive post-MI patients referred to a cardiac rehabilitation program with negative exercise stress test were studied. RESULTS Of these, 236 patients had DM at baseline. Over a mean follow-up of 5 years, 67 patients with DM (28.4%) and 76 of 374 patients without DM (20.2%) had died with a hazard ratio (HR) of 1.74 (95% CI: 1.28-2.56; P < 0.001). Patients with DM also had a higher incidence of cardiac death (1.84 [1.16-3.21]; P = 0.01), principally due to a higher incidence of sudden cardiac death (2.14 [1.22-4.23]; P < 0.001). Multiple Cox regression analysis revealed that only DM (adjusted HR: 1.9 [95% CI: 1.04-3.40]; P = 0.04), left ventricular ejection fraction (LVEF) II (4.2 [1.87-9.45]; P < 0.01) were independent predictors for sudden cardiac death. Among patients with DM, the 5-year sudden cardiac death rate did not differ significantly among those with LVEF 50% (8.8 vs. 7.8 vs. 6.8%, respectively; P = 0.83). CONCLUSIONS Post-MI patients with DM, even in the absence of residual myocardial ischemia clinically, were at higher risk of sudden cardiac death than their non-DM counterparts.
Persistent Identifierhttp://hdl.handle.net/10722/164334
ISSN
2013 Impact Factor: 8.570
PubMed Central ID
ISI Accession Number ID

 

Author Affiliations
  1. The University of Hong Kong
  2. Tung Wah Hospital
DC FieldValueLanguage
dc.contributor.authorYeung, CYen_US
dc.contributor.authorLam, KSLen_US
dc.contributor.authorLi, SWen_US
dc.contributor.authorLam, KFen_US
dc.contributor.authorTse, HFen_US
dc.contributor.authorSiu, CWen_US
dc.date.accessioned2012-09-20T07:58:01Z-
dc.date.available2012-09-20T07:58:01Z-
dc.date.issued2012en_US
dc.identifier.citationDiabetes Care, 2012, v. 35 n. 12, p. 2564-2569en_US
dc.identifier.issn0149-5992-
dc.identifier.urihttp://hdl.handle.net/10722/164334-
dc.description.abstractOBJECTIVE Diabetes mellitus (DM) is a well-established risk factor for coronary artery disease. Nonetheless, it remains unclear whether DM contributes to sudden cardiac death in patients who survive myocardial infarction (MI). The objective of this study was to compare the incidence of sudden cardiac death post-MI in diabetic and nondiabetic patients with no residual myocardial ischemia. RESEARCH DESIGN AND METHODS A total of 610 consecutive post-MI patients referred to a cardiac rehabilitation program with negative exercise stress test were studied. RESULTS Of these, 236 patients had DM at baseline. Over a mean follow-up of 5 years, 67 patients with DM (28.4%) and 76 of 374 patients without DM (20.2%) had died with a hazard ratio (HR) of 1.74 (95% CI: 1.28-2.56; P < 0.001). Patients with DM also had a higher incidence of cardiac death (1.84 [1.16-3.21]; P = 0.01), principally due to a higher incidence of sudden cardiac death (2.14 [1.22-4.23]; P < 0.001). Multiple Cox regression analysis revealed that only DM (adjusted HR: 1.9 [95% CI: 1.04-3.40]; P = 0.04), left ventricular ejection fraction (LVEF) </=30% (3.6 [1.46-8.75]; P < 0.01), and New York Heart Association functional class >II (4.2 [1.87-9.45]; P < 0.01) were independent predictors for sudden cardiac death. Among patients with DM, the 5-year sudden cardiac death rate did not differ significantly among those with LVEF </=30%, LVEF 31-50%, or LVEF >50% (8.8 vs. 7.8 vs. 6.8%, respectively; P = 0.83). CONCLUSIONS Post-MI patients with DM, even in the absence of residual myocardial ischemia clinically, were at higher risk of sudden cardiac death than their non-DM counterparts.-
dc.languageengen_US
dc.publisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/-
dc.relation.ispartofDiabetes Careen_US
dc.titleSudden cardiac death after myocardial infarction in type 2 diabetic patients with no residual myocardial ischemiaen_US
dc.typeArticleen_US
dc.identifier.emailLam, KSL: ksllam@hku.hken_US
dc.identifier.emailLam, KF: hrntlkf@hkucc.hku.hken_US
dc.identifier.emailTse, HF: hftse@hkucc.hku.hken_US
dc.identifier.emailSiu, CW: cwdsiu@hkucc.hku.hken_US
dc.identifier.authorityLam, KSL=rp00343en_US
dc.identifier.authorityLam, KF=rp00718en_US
dc.identifier.authorityTse, HF=rp00428en_US
dc.identifier.authoritySiu, CW=rp00534en_US
dc.identifier.doi10.2337/dc12-0118-
dc.identifier.pmid22875229-
dc.identifier.pmcidPMC3507604-
dc.identifier.scopuseid_2-s2.0-84869792154-
dc.identifier.hkuros209326en_US
dc.identifier.volume35en_US
dc.identifier.issue12-
dc.identifier.spage2564-
dc.identifier.epage2569-
dc.identifier.eissn1935-5548-
dc.identifier.isiWOS:000311426000042-
dc.publisher.placeUnited States-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats