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Article: Revisiting the marrow metabolic changes after chemotherapy in lymphoma: a step towards personalized care

TitleRevisiting the marrow metabolic changes after chemotherapy in lymphoma: a step towards personalized care
Authors
Issue Date2011
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/ijmi/
Citation
International Journal of Molecular Imaging, 2011, v. 2011, article no. 942063 How to Cite?
AbstractPurpose. The aims were to correlate individual marrow metabolic changes after chemotherapy with bone marrow biopsy (BMBx) for its potential value of personalized care in lymphoma. Methods. 26 patients (mean age, 58 +/- 15 y; 13 female, 13 male) with follicular lymphoma or diffuse large B-cell lymphoma, referred to FDG-PET/CT imaging, who had BMBx from unilateral or bilateral iliac crest(s) before chemotherapy, were studied retrospectively. The maximal standardized uptake value (SUV) was measured from BMBx site over the same area on both initial staging and first available restaging FDG-PET/CT scan. Results. 35 BMBx sites in 26 patients were evaluated. 12 of 35 sites were BMBx positive with interval decrease in SUV in 11 of 12 sites (92%). The remaining 23 of 35 sites were BMBx negative with interval increase in SUV in 21 of 23 sites (91%). The correlation between SUV change over the BMBx site before and after chemotherapy and BMBx result was significant (P < 0.0001). Conclusions. This preliminary result demonstrates a strong correlation between marrow metabolic changes (as determined by FDG PET) after chemotherapy and bone marrow involvement proven by biopsy. This may provide a retrospective means of personalized management of marrow involvement in deciding whether to deliver more extended therapy or closer followup of lymphoma patients.
Persistent Identifierhttp://hdl.handle.net/10722/163934
ISSN
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorTang, Ben_US
dc.contributor.authorPatel, MMen_US
dc.contributor.authorWong, RHen_US
dc.contributor.authorWood, Den_US
dc.contributor.authorWong, COen_US
dc.contributor.authorWu, Den_US
dc.contributor.authorKhong, PLen_US
dc.contributor.authorWong, CYOen_US
dc.date.accessioned2012-09-20T07:53:33Z-
dc.date.available2012-09-20T07:53:33Z-
dc.date.issued2011en_US
dc.identifier.citationInternational Journal of Molecular Imaging, 2011, v. 2011, article no. 942063en_US
dc.identifier.issn2090-1712-
dc.identifier.urihttp://hdl.handle.net/10722/163934-
dc.description.abstractPurpose. The aims were to correlate individual marrow metabolic changes after chemotherapy with bone marrow biopsy (BMBx) for its potential value of personalized care in lymphoma. Methods. 26 patients (mean age, 58 +/- 15 y; 13 female, 13 male) with follicular lymphoma or diffuse large B-cell lymphoma, referred to FDG-PET/CT imaging, who had BMBx from unilateral or bilateral iliac crest(s) before chemotherapy, were studied retrospectively. The maximal standardized uptake value (SUV) was measured from BMBx site over the same area on both initial staging and first available restaging FDG-PET/CT scan. Results. 35 BMBx sites in 26 patients were evaluated. 12 of 35 sites were BMBx positive with interval decrease in SUV in 11 of 12 sites (92%). The remaining 23 of 35 sites were BMBx negative with interval increase in SUV in 21 of 23 sites (91%). The correlation between SUV change over the BMBx site before and after chemotherapy and BMBx result was significant (P < 0.0001). Conclusions. This preliminary result demonstrates a strong correlation between marrow metabolic changes (as determined by FDG PET) after chemotherapy and bone marrow involvement proven by biopsy. This may provide a retrospective means of personalized management of marrow involvement in deciding whether to deliver more extended therapy or closer followup of lymphoma patients.-
dc.languageengen_US
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/ijmi/-
dc.relation.ispartofInternational Journal of Molecular Imagingen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleRevisiting the marrow metabolic changes after chemotherapy in lymphoma: a step towards personalized careen_US
dc.typeArticleen_US
dc.identifier.emailKhong, PL: plkhong@hkucc.hku.hken_US
dc.identifier.authorityKhong, PL=rp00467en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1155/2011/942063-
dc.identifier.pmid21966591-
dc.identifier.pmcidPMC3182335-
dc.identifier.hkuros206672en_US
dc.identifier.volume2011, article no. 942063-
dc.publisher.placeUnited States-

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