File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Tumor suppressor genes on frequently deleted chromosome 3p in nasopharyngeal carcinoma
  • Basic View
  • Metadata View
  • XML View
TitleTumor suppressor genes on frequently deleted chromosome 3p in nasopharyngeal carcinoma
 
AuthorsChen, J
Fu, L
Zhang, LY
Kwong, DLW
Li, Y
Guan, XY
 
KeywordsTumor suppressor gene
Deletion of 3p
Nasopharyngeal carcinoma
 
Issue Date2012
 
PublisherSun Yat-sen University Cancer Center. The Journal's web site is located at http://www.cjcsysu.cn/
 
CitationChinese Journal of Cancer, 2012, v. 31 n. 5, p. 215-222 [How to Cite?]
DOI: http://dx.doi.org/10.5732/cjc.011.10364
 
AbstractNasopharyngeal carcinoma (NPC) is among the most common malignancies in southern China. Deletion of genomic DNA, which occurs during the complex pathogenesis process for NPC, represents a pivotal mechanism in the inactivation of tumor suppressor genes (TSGs). In many circumstances, loss of TSGs can be detected as diagnostic and prognostic markers in cancer. The short arm of chromosome 3 (3p) is a frequently deleted chromosomal region in NPC, with 3p21.1-21.2 and 3p25.2-26.1 being the most frequently deleted minimal regions. In recent years, our research group and others have focused on the identification and characterization of novel target TSGs at 3p, such as RASSF1A, BLU, RBMS3, and CHL1, in the development and progression of NPC. In this review, we summarize recent findings of TSGs at 3p and discuss some of these genes in detail. A better understanding of TSGs at 3p will significantly improve our understanding of NPC pathogenesis, diagnosis, and treatment.
 
ISSN1000-467X
2013 SCImago Journal Rankings: 0.706
 
DOIhttp://dx.doi.org/10.5732/cjc.011.10364
 
DC FieldValue
dc.contributor.authorChen, J
 
dc.contributor.authorFu, L
 
dc.contributor.authorZhang, LY
 
dc.contributor.authorKwong, DLW
 
dc.contributor.authorLi, Y
 
dc.contributor.authorGuan, XY
 
dc.date.accessioned2012-09-20T07:53:12Z
 
dc.date.available2012-09-20T07:53:12Z
 
dc.date.issued2012
 
dc.description.abstractNasopharyngeal carcinoma (NPC) is among the most common malignancies in southern China. Deletion of genomic DNA, which occurs during the complex pathogenesis process for NPC, represents a pivotal mechanism in the inactivation of tumor suppressor genes (TSGs). In many circumstances, loss of TSGs can be detected as diagnostic and prognostic markers in cancer. The short arm of chromosome 3 (3p) is a frequently deleted chromosomal region in NPC, with 3p21.1-21.2 and 3p25.2-26.1 being the most frequently deleted minimal regions. In recent years, our research group and others have focused on the identification and characterization of novel target TSGs at 3p, such as RASSF1A, BLU, RBMS3, and CHL1, in the development and progression of NPC. In this review, we summarize recent findings of TSGs at 3p and discuss some of these genes in detail. A better understanding of TSGs at 3p will significantly improve our understanding of NPC pathogenesis, diagnosis, and treatment.
 
dc.description.naturelink_to_OA_fulltext
 
dc.identifier.citationChinese Journal of Cancer, 2012, v. 31 n. 5, p. 215-222 [How to Cite?]
DOI: http://dx.doi.org/10.5732/cjc.011.10364
 
dc.identifier.doihttp://dx.doi.org/10.5732/cjc.011.10364
 
dc.identifier.epage222
 
dc.identifier.hkuros210077
 
dc.identifier.hkuros203487
 
dc.identifier.issn1000-467X
2013 SCImago Journal Rankings: 0.706
 
dc.identifier.issue5
 
dc.identifier.pmid22360856
 
dc.identifier.spage215
 
dc.identifier.urihttp://hdl.handle.net/10722/163921
 
dc.identifier.volume31
 
dc.languageeng
 
dc.publisherSun Yat-sen University Cancer Center. The Journal's web site is located at http://www.cjcsysu.cn/
 
dc.publisher.placeChina
 
dc.relation.ispartofChinese Journal of Cancer
 
dc.subjectTumor suppressor gene
 
dc.subjectDeletion of 3p
 
dc.subjectNasopharyngeal carcinoma
 
dc.titleTumor suppressor genes on frequently deleted chromosome 3p in nasopharyngeal carcinoma
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Chen, J</contributor.author>
<contributor.author>Fu, L</contributor.author>
<contributor.author>Zhang, LY</contributor.author>
<contributor.author>Kwong, DLW</contributor.author>
<contributor.author>Li, Y</contributor.author>
<contributor.author>Guan, XY</contributor.author>
<date.accessioned>2012-09-20T07:53:12Z</date.accessioned>
<date.available>2012-09-20T07:53:12Z</date.available>
<date.issued>2012</date.issued>
<identifier.citation>Chinese Journal of Cancer, 2012, v. 31 n. 5, p. 215-222</identifier.citation>
<identifier.issn>1000-467X</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/163921</identifier.uri>
<description.abstract>Nasopharyngeal carcinoma (NPC) is among the most common malignancies in southern China. Deletion of genomic DNA, which occurs during the complex pathogenesis process for NPC, represents a pivotal mechanism in the inactivation of tumor suppressor genes (TSGs). In many circumstances, loss of TSGs can be detected as diagnostic and prognostic markers in cancer. The short arm of chromosome 3 (3p) is a frequently deleted chromosomal region in NPC, with 3p21.1-21.2 and 3p25.2-26.1 being the most frequently deleted minimal regions. In recent years, our research group and others have focused on the identification and characterization of novel target TSGs at 3p, such as RASSF1A, BLU, RBMS3, and CHL1, in the development and progression of NPC. In this review, we summarize recent findings of TSGs at 3p and discuss some of these genes in detail. A better understanding of TSGs at 3p will significantly improve our understanding of NPC pathogenesis, diagnosis, and treatment.</description.abstract>
<language>eng</language>
<publisher>Sun Yat-sen University Cancer Center. The Journal&apos;s web site is located at http://www.cjcsysu.cn/</publisher>
<relation.ispartof>Chinese Journal of Cancer</relation.ispartof>
<subject>Tumor suppressor gene</subject>
<subject>Deletion of 3p</subject>
<subject>Nasopharyngeal carcinoma</subject>
<title>Tumor suppressor genes on frequently deleted chromosome 3p in nasopharyngeal carcinoma</title>
<type>Article</type>
<description.nature>link_to_OA_fulltext</description.nature>
<identifier.doi>10.5732/cjc.011.10364</identifier.doi>
<identifier.pmid>22360856</identifier.pmid>
<identifier.hkuros>210077</identifier.hkuros>
<identifier.hkuros>203487</identifier.hkuros>
<identifier.volume>31</identifier.volume>
<identifier.issue>5</identifier.issue>
<identifier.spage>215</identifier.spage>
<identifier.epage>222</identifier.epage>
<publisher.place>China</publisher.place>
<bitstream.url>http://hub.hku.hk/bitstream/10722/163921/1/re01.htm</bitstream.url>
</item>