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Article: Tumor suppressor genes on frequently deleted chromosome 3p in nasopharyngeal carcinoma

TitleTumor suppressor genes on frequently deleted chromosome 3p in nasopharyngeal carcinoma
Authors
KeywordsTumor suppressor gene
Deletion of 3p
Nasopharyngeal carcinoma
Issue Date2012
PublisherSun Yat-sen University Cancer Center. The Journal's web site is located at http://www.cjcsysu.cn/
Citation
Chinese Journal of Cancer, 2012, v. 31 n. 5, p. 215-222 How to Cite?
AbstractNasopharyngeal carcinoma (NPC) is among the most common malignancies in southern China. Deletion of genomic DNA, which occurs during the complex pathogenesis process for NPC, represents a pivotal mechanism in the inactivation of tumor suppressor genes (TSGs). In many circumstances, loss of TSGs can be detected as diagnostic and prognostic markers in cancer. The short arm of chromosome 3 (3p) is a frequently deleted chromosomal region in NPC, with 3p21.1-21.2 and 3p25.2-26.1 being the most frequently deleted minimal regions. In recent years, our research group and others have focused on the identification and characterization of novel target TSGs at 3p, such as RASSF1A, BLU, RBMS3, and CHL1, in the development and progression of NPC. In this review, we summarize recent findings of TSGs at 3p and discuss some of these genes in detail. A better understanding of TSGs at 3p will significantly improve our understanding of NPC pathogenesis, diagnosis, and treatment.
Persistent Identifierhttp://hdl.handle.net/10722/163921
ISSN
2014 Impact Factor: 2.155
2014 SCImago Journal Rankings: 0.871
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChen, Jen_US
dc.contributor.authorFu, Len_US
dc.contributor.authorZhang, LYen_US
dc.contributor.authorKwong, DLWen_US
dc.contributor.authorLi, Yen_US
dc.contributor.authorGuan, XYen_US
dc.date.accessioned2012-09-20T07:53:12Z-
dc.date.available2012-09-20T07:53:12Z-
dc.date.issued2012en_US
dc.identifier.citationChinese Journal of Cancer, 2012, v. 31 n. 5, p. 215-222en_US
dc.identifier.issn1000-467X-
dc.identifier.urihttp://hdl.handle.net/10722/163921-
dc.description.abstractNasopharyngeal carcinoma (NPC) is among the most common malignancies in southern China. Deletion of genomic DNA, which occurs during the complex pathogenesis process for NPC, represents a pivotal mechanism in the inactivation of tumor suppressor genes (TSGs). In many circumstances, loss of TSGs can be detected as diagnostic and prognostic markers in cancer. The short arm of chromosome 3 (3p) is a frequently deleted chromosomal region in NPC, with 3p21.1-21.2 and 3p25.2-26.1 being the most frequently deleted minimal regions. In recent years, our research group and others have focused on the identification and characterization of novel target TSGs at 3p, such as RASSF1A, BLU, RBMS3, and CHL1, in the development and progression of NPC. In this review, we summarize recent findings of TSGs at 3p and discuss some of these genes in detail. A better understanding of TSGs at 3p will significantly improve our understanding of NPC pathogenesis, diagnosis, and treatment.-
dc.languageengen_US
dc.publisherSun Yat-sen University Cancer Center. The Journal's web site is located at http://www.cjcsysu.cn/-
dc.relation.ispartofChinese Journal of Canceren_US
dc.subjectTumor suppressor gene-
dc.subjectDeletion of 3p-
dc.subjectNasopharyngeal carcinoma-
dc.titleTumor suppressor genes on frequently deleted chromosome 3p in nasopharyngeal carcinomaen_US
dc.typeArticleen_US
dc.identifier.emailFu, L: gracefu@graduate.hku.hken_US
dc.identifier.emailKwong, DLW: dlwkwong@hku.hken_US
dc.identifier.emailGuan, XY: xyguan@hkucc.hku.hken_US
dc.identifier.authorityFu, L=rp01435en_US
dc.identifier.authorityKwong, DLW=rp00414en_US
dc.identifier.authorityGuan, XY=rp00454en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.5732/cjc.011.10364-
dc.identifier.pmid22360856-
dc.identifier.pmcidPMC3777521-
dc.identifier.hkuros210077en_US
dc.identifier.hkuros203487-
dc.identifier.volume31en_US
dc.identifier.issue5en_US
dc.identifier.spage215en_US
dc.identifier.epage222en_US
dc.identifier.isiWOS:000209009000001-
dc.publisher.placeChina-

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