Article: Tumor suppressor genes on frequently deleted chromosome 3p in nasopharyngeal carcinoma

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TitleTumor suppressor genes on frequently deleted chromosome 3p in nasopharyngeal carcinoma
AuthorsChen, J
Fu, L
Zhang, LY
Kwong, DLW
Li, Y
Guan, XY
KeywordsTumor suppressor gene
Deletion of 3p
Nasopharyngeal carcinoma
Issue Date2012
PublisherSun Yat-sen University Cancer Center. The Journal's web site is located at http://www.cjcsysu.cn/
CitationChinese Journal of Cancer, 2012, v. 31 n. 5, p. 215-222 [How to Cite?]
DOI: http://dx.doi.org/10.5732/cjc.011.10364
AbstractNasopharyngeal carcinoma (NPC) is among the most common malignancies in southern China. Deletion of genomic DNA, which occurs during the complex pathogenesis process for NPC, represents a pivotal mechanism in the inactivation of tumor suppressor genes (TSGs). In many circumstances, loss of TSGs can be detected as diagnostic and prognostic markers in cancer. The short arm of chromosome 3 (3p) is a frequently deleted chromosomal region in NPC, with 3p21.1-21.2 and 3p25.2-26.1 being the most frequently deleted minimal regions. In recent years, our research group and others have focused on the identification and characterization of novel target TSGs at 3p, such as RASSF1A, BLU, RBMS3, and CHL1, in the development and progression of NPC. In this review, we summarize recent findings of TSGs at 3p and discuss some of these genes in detail. A better understanding of TSGs at 3p will significantly improve our understanding of NPC pathogenesis, diagnosis, and treatment.
ISSN1000-467X
2011 SCImago Journal Rankings: 0.043
DOIhttp://dx.doi.org/10.5732/cjc.011.10364
DC Field
Value
dc.contributor.authorChen, J
dc.contributor.authorFu, L
dc.contributor.authorZhang, LY
dc.contributor.authorKwong, DLW
dc.contributor.authorLi, Y
dc.contributor.authorGuan, XY
dc.date.accessioned2012-09-20T07:53:12Z
dc.date.available2012-09-20T07:53:12Z
dc.date.issued2012
dc.description.abstractNasopharyngeal carcinoma (NPC) is among the most common malignancies in southern China. Deletion of genomic DNA, which occurs during the complex pathogenesis process for NPC, represents a pivotal mechanism in the inactivation of tumor suppressor genes (TSGs). In many circumstances, loss of TSGs can be detected as diagnostic and prognostic markers in cancer. The short arm of chromosome 3 (3p) is a frequently deleted chromosomal region in NPC, with 3p21.1-21.2 and 3p25.2-26.1 being the most frequently deleted minimal regions. In recent years, our research group and others have focused on the identification and characterization of novel target TSGs at 3p, such as RASSF1A, BLU, RBMS3, and CHL1, in the development and progression of NPC. In this review, we summarize recent findings of TSGs at 3p and discuss some of these genes in detail. A better understanding of TSGs at 3p will significantly improve our understanding of NPC pathogenesis, diagnosis, and treatment.
dc.description.naturelink_to_OA_fulltext
dc.identifier.citationChinese Journal of Cancer, 2012, v. 31 n. 5, p. 215-222 [How to Cite?]
DOI: http://dx.doi.org/10.5732/cjc.011.10364
dc.identifier.doihttp://dx.doi.org/10.5732/cjc.011.10364
dc.identifier.epage222
dc.identifier.hkuros210077
dc.identifier.hkuros203487
dc.identifier.issn1000-467X
2011 SCImago Journal Rankings: 0.043
dc.identifier.issue5
dc.identifier.pmid22360856
dc.identifier.spage215
dc.identifier.urihttp://hdl.handle.net/10722/163921
dc.identifier.volume31
dc.languageeng
dc.publisherSun Yat-sen University Cancer Center. The Journal's web site is located at http://www.cjcsysu.cn/
dc.publisher.placeChina
dc.relation.ispartofChinese Journal of Cancer
dc.subjectTumor suppressor gene
dc.subjectDeletion of 3p
dc.subjectNasopharyngeal carcinoma
dc.titleTumor suppressor genes on frequently deleted chromosome 3p in nasopharyngeal carcinoma
dc.typeArticle