File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: An ORMOSIL-containing orthodontic acrylic resin with concomitant improvements in antimicrobial and fracture toughness properties

TitleAn ORMOSIL-containing orthodontic acrylic resin with concomitant improvements in antimicrobial and fracture toughness properties
Authors
KeywordsAcrylic acid resin
Actinomyces naeslundii
Animal cell
Antibiotic resistance
Antifungal activity
Issue Date2012
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
PLoS One, 2012, v. 7 n. 8, article no. e42355 How to Cite?
AbstractGlobal increase in patients seeking orthodontic treatment creates a demand for the use of acrylic resins in removable appliances and retainers. Orthodontic removable appliance wearers have a higher risk of oral infections that are caused by the formation of bacterial and fungal biofilms on the appliance surface. Here, we present the synthetic route for an antibacterial and antifungal organically-modified silicate (ORMOSIL) that has multiple methacryloloxy functionalities attached to a siloxane backbone (quaternary ammonium methacryloxy silicate, or QAMS). By dissolving the water-insoluble, rubbery ORMOSIL in methyl methacrylate, QAMS may be copolymerized with polymethyl methacrylate, and covalently incorporated in the pressure-processed acrylic resin. The latter demonstrated a predominantly contact-killing effect on Streptococcus mutans ATCC 36558 and Actinomyces naselundii ATCC 12104 biofilms, while inhibiting adhesion of Candida albicans ATCC 90028 on the acrylic surface. Apart from its favorable antimicrobial activities, QAMS-containing acrylic resins exhibited decreased water wettability and improved toughness, without adversely affecting the flexural strength and modulus, water sorption and solubility, when compared with QAMS-free acrylic resin. The covalently bound, antimicrobial orthodontic acrylic resin with improved toughness represents advancement over other experimental antimicrobial acrylic resin formulations, in its potential to simultaneously prevent oral infections during appliance wear, and improve the fracture resistance of those appliances.
Persistent Identifierhttp://hdl.handle.net/10722/163743
ISSN
2015 Impact Factor: 3.057
2015 SCImago Journal Rankings: 1.395
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGong, SQen_US
dc.contributor.authorEpasinghe, Jen_US
dc.contributor.authorRueggeberg, FAen_US
dc.contributor.authorNiu, LNen_US
dc.contributor.authorMettenberg, Den_US
dc.contributor.authorYiu, CKYen_US
dc.contributor.authorBlizzard, JDen_US
dc.contributor.authorWu, CDen_US
dc.contributor.authorMao, Jen_US
dc.contributor.authorDrisko, CLen_US
dc.contributor.authorPashley, DHen_US
dc.contributor.authorTay, FR-
dc.date.accessioned2012-09-20T07:50:36Z-
dc.date.available2012-09-20T07:50:36Z-
dc.date.issued2012en_US
dc.identifier.citationPLoS One, 2012, v. 7 n. 8, article no. e42355en_US
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/10722/163743-
dc.description.abstractGlobal increase in patients seeking orthodontic treatment creates a demand for the use of acrylic resins in removable appliances and retainers. Orthodontic removable appliance wearers have a higher risk of oral infections that are caused by the formation of bacterial and fungal biofilms on the appliance surface. Here, we present the synthetic route for an antibacterial and antifungal organically-modified silicate (ORMOSIL) that has multiple methacryloloxy functionalities attached to a siloxane backbone (quaternary ammonium methacryloxy silicate, or QAMS). By dissolving the water-insoluble, rubbery ORMOSIL in methyl methacrylate, QAMS may be copolymerized with polymethyl methacrylate, and covalently incorporated in the pressure-processed acrylic resin. The latter demonstrated a predominantly contact-killing effect on Streptococcus mutans ATCC 36558 and Actinomyces naselundii ATCC 12104 biofilms, while inhibiting adhesion of Candida albicans ATCC 90028 on the acrylic surface. Apart from its favorable antimicrobial activities, QAMS-containing acrylic resins exhibited decreased water wettability and improved toughness, without adversely affecting the flexural strength and modulus, water sorption and solubility, when compared with QAMS-free acrylic resin. The covalently bound, antimicrobial orthodontic acrylic resin with improved toughness represents advancement over other experimental antimicrobial acrylic resin formulations, in its potential to simultaneously prevent oral infections during appliance wear, and improve the fracture resistance of those appliances.-
dc.languageengen_US
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action-
dc.relation.ispartofPLoS Oneen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAcrylic acid resin-
dc.subjectActinomyces naeslundii-
dc.subjectAnimal cell-
dc.subjectAntibiotic resistance-
dc.subjectAntifungal activity-
dc.titleAn ORMOSIL-containing orthodontic acrylic resin with concomitant improvements in antimicrobial and fracture toughness propertiesen_US
dc.typeArticleen_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0042355-
dc.identifier.pmid22870322-
dc.identifier.pmcidPMC3411672-
dc.identifier.scopuseid_2-s2.0-84864767907-
dc.identifier.hkuros210268en_US
dc.identifier.volume7en_US
dc.identifier.issue8, article no. e42355-
dc.identifier.isiWOS:000307212800085-
dc.publisher.placeUnited States-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats