Article: In vitro attenuation of acrolein-induced toxicity by phloretin, a phenolic compound from apple

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Publisher Website: 10.1016/j.foodchem.2012.06.053
Scopus: eid_2-s2.0-84865731529
PMID: 22953919

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Title	In vitro attenuation of acrolein-induced toxicity by phloretin, a phenolic compound from apple
Authors	Zhu, Q2 3 Zhang, NQS1 Lau, CF1 Chao, J3 Sun, Z3 Chang, RCC1 Chen, F4 Wang, M3
Keywords	Acrolein ALEs FDP-lysine Phloretin RCS
Issue Date	2012
Publisher	Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/foodchem
Citation	Food Chemistry, 2012, v. 135 n. 3, p. 1762-1768 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.foodchem.2012.06.053
Abstract	In the current study, the protective effects of phloretin were investigated in acrolein-challenged amino acid, protein, and cell models. It was found that the formation of FDP-lysine (a typical acrolein-lysine adduct) was strongly inhibited in the presence of phloretin and the remaining electrophilic site in FDP-lysine was also blocked by phloretin. Moreover, direct trapping of acrolein by phloretin was found to be responsible for inhibiting the incorporation of carbonyl groups into BSA and oligomerisation in RNase A. Subsequently, the reduction of LDH release in human neuroblastoma SH-SY5Y cells under acrolein challenge suggested the cytoprotective effects of phloretin. Such protection might be mediated through inhibiting the increased cellular protein carbonyl level as revealed by Western blotting analysis. The present study highlighted an apple phenolic compound, phloretin as a promising candidate in prevention or treatment of acrolein-associated human diseases. © 2012 Elsevier Ltd. All rights reserved.
ISSN	0308-8146 2011 Impact Factor: 3.655 2011 SCImago Journal Rankings: 0.137
DOI	http://dx.doi.org/10.1016/j.foodchem.2012.06.053
References	References in Scopus

DC Field	Value
dc.contributor.author	Zhu, Q
dc.contributor.author	Zhang, NQS
dc.contributor.author	Lau, CF
dc.contributor.author	Chao, J
dc.contributor.author	Sun, Z
dc.contributor.author	Chang, RCC
dc.contributor.author	Chen, F
dc.contributor.author	Wang, M
dc.date.accessioned	2012-09-12T01:42:19Z
dc.date.available	2012-09-12T01:42:19Z
dc.date.issued	2012
dc.description.abstract	In the current study, the protective effects of phloretin were investigated in acrolein-challenged amino acid, protein, and cell models. It was found that the formation of FDP-lysine (a typical acrolein-lysine adduct) was strongly inhibited in the presence of phloretin and the remaining electrophilic site in FDP-lysine was also blocked by phloretin. Moreover, direct trapping of acrolein by phloretin was found to be responsible for inhibiting the incorporation of carbonyl groups into BSA and oligomerisation in RNase A. Subsequently, the reduction of LDH release in human neuroblastoma SH-SY5Y cells under acrolein challenge suggested the cytoprotective effects of phloretin. Such protection might be mediated through inhibiting the increased cellular protein carbonyl level as revealed by Western blotting analysis. The present study highlighted an apple phenolic compound, phloretin as a promising candidate in prevention or treatment of acrolein-associated human diseases. © 2012 Elsevier Ltd. All rights reserved.
dc.description.nature	Link_to_subscribed_fulltext
dc.identifier.citation	Food Chemistry, 2012, v. 135 n. 3, p. 1762-1768 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.foodchem.2012.06.053
dc.identifier.doi	http://dx.doi.org/10.1016/j.foodchem.2012.06.053
dc.identifier.epage	1768
dc.identifier.hkuros	206145
dc.identifier.issn	0308-8146 2011 Impact Factor: 3.655 2011 SCImago Journal Rankings: 0.137
dc.identifier.issue	3
dc.identifier.pmid	22953919
dc.identifier.scopus	eid_2-s2.0-84865731529
dc.identifier.spage	1762
dc.identifier.uri	http://hdl.handle.net/10722/163616
dc.identifier.volume	135
dc.language	eng
dc.publisher	Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/foodchem
dc.publisher.place	Netherlands
dc.relation.ispartof	Food Chemistry
dc.relation.references	References in Scopus
dc.subject	Acrolein
dc.subject	ALEs
dc.subject	FDP-lysine
dc.subject	Phloretin
dc.subject	RCS
dc.title	In vitro attenuation of acrolein-induced toxicity by phloretin, a phenolic compound from apple
dc.type	Article

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Author Affiliations

The University of Hong Kong Li Ka Shing Faculty of Medicine
Hangzhou Normal University
The University of Hong Kong
Peking University

Article: In vitro attenuation of acrolein-induced toxicity by phloretin, a phenolic compound from apple

The HKU Scholars Hub has contact details for these author(s).