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Article: In vitro attenuation of acrolein-induced toxicity by phloretin, a phenolic compound from apple

TitleIn vitro attenuation of acrolein-induced toxicity by phloretin, a phenolic compound from apple
Authors
KeywordsAcrolein
ALEs
FDP-lysine
Phloretin
RCS
Issue Date2012
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/foodchem
Citation
Food Chemistry, 2012, v. 135 n. 3, p. 1762-1768 How to Cite?
Abstract
In the current study, the protective effects of phloretin were investigated in acrolein-challenged amino acid, protein, and cell models. It was found that the formation of FDP-lysine (a typical acrolein-lysine adduct) was strongly inhibited in the presence of phloretin and the remaining electrophilic site in FDP-lysine was also blocked by phloretin. Moreover, direct trapping of acrolein by phloretin was found to be responsible for inhibiting the incorporation of carbonyl groups into BSA and oligomerisation in RNase A. Subsequently, the reduction of LDH release in human neuroblastoma SH-SY5Y cells under acrolein challenge suggested the cytoprotective effects of phloretin. Such protection might be mediated through inhibiting the increased cellular protein carbonyl level as revealed by Western blotting analysis. The present study highlighted an apple phenolic compound, phloretin as a promising candidate in prevention or treatment of acrolein-associated human diseases. © 2012 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/163616
ISSN
2013 Impact Factor: 3.259
2013 SCImago Journal Rankings: 1.559
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhu, Qen_HK
dc.contributor.authorZhang, NQSen_HK
dc.contributor.authorLau, CFen_HK
dc.contributor.authorChao, Jen_HK
dc.contributor.authorSun, Zen_HK
dc.contributor.authorChang, RCCen_HK
dc.contributor.authorChen, Fen_HK
dc.contributor.authorWang, Men_HK
dc.date.accessioned2012-09-12T01:42:19Z-
dc.date.available2012-09-12T01:42:19Z-
dc.date.issued2012en_HK
dc.identifier.citationFood Chemistry, 2012, v. 135 n. 3, p. 1762-1768en_HK
dc.identifier.issn0308-8146en_HK
dc.identifier.urihttp://hdl.handle.net/10722/163616-
dc.description.abstractIn the current study, the protective effects of phloretin were investigated in acrolein-challenged amino acid, protein, and cell models. It was found that the formation of FDP-lysine (a typical acrolein-lysine adduct) was strongly inhibited in the presence of phloretin and the remaining electrophilic site in FDP-lysine was also blocked by phloretin. Moreover, direct trapping of acrolein by phloretin was found to be responsible for inhibiting the incorporation of carbonyl groups into BSA and oligomerisation in RNase A. Subsequently, the reduction of LDH release in human neuroblastoma SH-SY5Y cells under acrolein challenge suggested the cytoprotective effects of phloretin. Such protection might be mediated through inhibiting the increased cellular protein carbonyl level as revealed by Western blotting analysis. The present study highlighted an apple phenolic compound, phloretin as a promising candidate in prevention or treatment of acrolein-associated human diseases. © 2012 Elsevier Ltd. All rights reserved.en_HK
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/foodchemen_HK
dc.relation.ispartofFood Chemistryen_HK
dc.subjectAcroleinen_HK
dc.subjectALEsen_HK
dc.subjectFDP-lysineen_HK
dc.subjectPhloretinen_HK
dc.subjectRCSen_HK
dc.titleIn vitro attenuation of acrolein-induced toxicity by phloretin, a phenolic compound from appleen_HK
dc.typeArticleen_HK
dc.identifier.emailWang, M: mfwang@hku.hken_HK
dc.identifier.authorityWang, M=rp00800en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.foodchem.2012.06.053en_HK
dc.identifier.pmid22953919-
dc.identifier.scopuseid_2-s2.0-84865731529en_HK
dc.identifier.hkuros206145-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84865731529&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume135en_HK
dc.identifier.issue3en_HK
dc.identifier.spage1762en_HK
dc.identifier.epage1768en_HK
dc.identifier.isiWOS:000310396700124-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridZhu, Q=54909442800en_HK
dc.identifier.scopusauthoridZhang, NQS=55350498000en_HK
dc.identifier.scopusauthoridLau, CF=25122803900en_HK
dc.identifier.scopusauthoridChao, J=24558959000en_HK
dc.identifier.scopusauthoridSun, Z=55350540200en_HK
dc.identifier.scopusauthoridChang, RCC=55252345900en_HK
dc.identifier.scopusauthoridChen, F=55307570100en_HK
dc.identifier.scopusauthoridWang, M=7406691844en_HK

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