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Article: In vitro attenuation of acrolein-induced toxicity by phloretin, a phenolic compound from apple
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TitleIn vitro attenuation of acrolein-induced toxicity by phloretin, a phenolic compound from apple
 
AuthorsZhu, Q2 3
Zhang, NQS1
Lau, CF1
Chao, J3
Sun, Z3
Chang, RCC1
Chen, F4
Wang, M3
 
KeywordsAcrolein
ALEs
FDP-lysine
Phloretin
RCS
 
Issue Date2012
 
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/foodchem
 
CitationFood Chemistry, 2012, v. 135 n. 3, p. 1762-1768 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.foodchem.2012.06.053
 
AbstractIn the current study, the protective effects of phloretin were investigated in acrolein-challenged amino acid, protein, and cell models. It was found that the formation of FDP-lysine (a typical acrolein-lysine adduct) was strongly inhibited in the presence of phloretin and the remaining electrophilic site in FDP-lysine was also blocked by phloretin. Moreover, direct trapping of acrolein by phloretin was found to be responsible for inhibiting the incorporation of carbonyl groups into BSA and oligomerisation in RNase A. Subsequently, the reduction of LDH release in human neuroblastoma SH-SY5Y cells under acrolein challenge suggested the cytoprotective effects of phloretin. Such protection might be mediated through inhibiting the increased cellular protein carbonyl level as revealed by Western blotting analysis. The present study highlighted an apple phenolic compound, phloretin as a promising candidate in prevention or treatment of acrolein-associated human diseases. © 2012 Elsevier Ltd. All rights reserved.
 
ISSN0308-8146
2013 Impact Factor: 3.259
2013 SCImago Journal Rankings: 1.559
 
DOIhttp://dx.doi.org/10.1016/j.foodchem.2012.06.053
 
ISI Accession Number IDWOS:000310396700124
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorZhu, Q
 
dc.contributor.authorZhang, NQS
 
dc.contributor.authorLau, CF
 
dc.contributor.authorChao, J
 
dc.contributor.authorSun, Z
 
dc.contributor.authorChang, RCC
 
dc.contributor.authorChen, F
 
dc.contributor.authorWang, M
 
dc.date.accessioned2012-09-12T01:42:19Z
 
dc.date.available2012-09-12T01:42:19Z
 
dc.date.issued2012
 
dc.description.abstractIn the current study, the protective effects of phloretin were investigated in acrolein-challenged amino acid, protein, and cell models. It was found that the formation of FDP-lysine (a typical acrolein-lysine adduct) was strongly inhibited in the presence of phloretin and the remaining electrophilic site in FDP-lysine was also blocked by phloretin. Moreover, direct trapping of acrolein by phloretin was found to be responsible for inhibiting the incorporation of carbonyl groups into BSA and oligomerisation in RNase A. Subsequently, the reduction of LDH release in human neuroblastoma SH-SY5Y cells under acrolein challenge suggested the cytoprotective effects of phloretin. Such protection might be mediated through inhibiting the increased cellular protein carbonyl level as revealed by Western blotting analysis. The present study highlighted an apple phenolic compound, phloretin as a promising candidate in prevention or treatment of acrolein-associated human diseases. © 2012 Elsevier Ltd. All rights reserved.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationFood Chemistry, 2012, v. 135 n. 3, p. 1762-1768 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.foodchem.2012.06.053
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.foodchem.2012.06.053
 
dc.identifier.epage1768
 
dc.identifier.hkuros206145
 
dc.identifier.isiWOS:000310396700124
 
dc.identifier.issn0308-8146
2013 Impact Factor: 3.259
2013 SCImago Journal Rankings: 1.559
 
dc.identifier.issue3
 
dc.identifier.pmid22953919
 
dc.identifier.scopuseid_2-s2.0-84865731529
 
dc.identifier.spage1762
 
dc.identifier.urihttp://hdl.handle.net/10722/163616
 
dc.identifier.volume135
 
dc.languageeng
 
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/foodchem
 
dc.publisher.placeNetherlands
 
dc.relation.ispartofFood Chemistry
 
dc.relation.referencesReferences in Scopus
 
dc.subjectAcrolein
 
dc.subjectALEs
 
dc.subjectFDP-lysine
 
dc.subjectPhloretin
 
dc.subjectRCS
 
dc.titleIn vitro attenuation of acrolein-induced toxicity by phloretin, a phenolic compound from apple
 
dc.typeArticle
 
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<contributor.author>Sun, Z</contributor.author>
<contributor.author>Chang, RCC</contributor.author>
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<contributor.author>Wang, M</contributor.author>
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. Hangzhou Normal University
  3. The University of Hong Kong
  4. Peking University