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Article: Biomedical applications of amino acid-modified chitosans: A review

TitleBiomedical applications of amino acid-modified chitosans: A review
Authors
KeywordsAmino acid
Chitosan
Drug delivery
Gene therapy
Tissue engineering
Issue Date2012
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterials
Citation
Biomaterials, 2012, v. 33 n. 30, p. 7565-7583 How to Cite?
AbstractThe presence of reactive primary amines in the backbone structure of chitosan, enables the derivatisation with different functional groups and thereby improving and expanding its properties, such as solubility and mucoadhesiveness, for biomedical applications. Such derivatives can be exploited with good results in a number of biomedical areas, including enhancement of nucleic acid transfection in gene therapy, as well as many other applications aiming to maximize drug delivery and aiding tissue engineering. The aim of this review is to provide an up to date overview of the methods used for derivatizing the chitosan with amino acids and to discuss the characteristics and potential biomedical application of the different amino acid derivatized chitosans described in the literature. © 2012 Elsevier Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/163613
ISSN
2015 Impact Factor: 8.387
2015 SCImago Journal Rankings: 3.565
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCasettari, Len_HK
dc.contributor.authorVllasaliu, Den_HK
dc.contributor.authorLam, JKWen_HK
dc.contributor.authorSoliman, Men_HK
dc.contributor.authorIllum, Len_HK
dc.date.accessioned2012-09-11T06:35:21Z-
dc.date.available2012-09-11T06:35:21Z-
dc.date.issued2012en_HK
dc.identifier.citationBiomaterials, 2012, v. 33 n. 30, p. 7565-7583en_HK
dc.identifier.issn0142-9612en_HK
dc.identifier.urihttp://hdl.handle.net/10722/163613-
dc.description.abstractThe presence of reactive primary amines in the backbone structure of chitosan, enables the derivatisation with different functional groups and thereby improving and expanding its properties, such as solubility and mucoadhesiveness, for biomedical applications. Such derivatives can be exploited with good results in a number of biomedical areas, including enhancement of nucleic acid transfection in gene therapy, as well as many other applications aiming to maximize drug delivery and aiding tissue engineering. The aim of this review is to provide an up to date overview of the methods used for derivatizing the chitosan with amino acids and to discuss the characteristics and potential biomedical application of the different amino acid derivatized chitosans described in the literature. © 2012 Elsevier Ltd.en_HK
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterialsen_HK
dc.relation.ispartofBiomaterialsen_HK
dc.subjectAmino aciden_HK
dc.subjectChitosanen_HK
dc.subjectDrug deliveryen_HK
dc.subjectGene therapyen_HK
dc.subjectTissue engineeringen_HK
dc.titleBiomedical applications of amino acid-modified chitosans: A reviewen_HK
dc.typeArticleen_HK
dc.identifier.emailLam, JKW: jkwlam@hku.hken_HK
dc.identifier.authorityLam, JKW=rp01346en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.biomaterials.2012.06.104en_HK
dc.identifier.pmid22818987-
dc.identifier.scopuseid_2-s2.0-84865001597en_HK
dc.identifier.hkuros206011-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84865001597&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume33en_HK
dc.identifier.issue30en_HK
dc.identifier.spage7565en_HK
dc.identifier.epage7583en_HK
dc.identifier.isiWOS:000308524000026-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridCasettari, L=24330679000en_HK
dc.identifier.scopusauthoridVllasaliu, D=36469304000en_HK
dc.identifier.scopusauthoridLam, JKW=8404243000en_HK
dc.identifier.scopusauthoridSoliman, M=55314341500en_HK
dc.identifier.scopusauthoridIllum, L=7005294646en_HK

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