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Article: Successful treatment of acquired factor VIII inhibitor with cyclosporin

TitleSuccessful treatment of acquired factor VIII inhibitor with cyclosporin
Authors
Issue Date2004
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/HAE
Citation
Haemophilia, 2004, v. 10 n. 1, p. 98-100 How to Cite?
AbstractAcquired factor VIII inhibitor causes a rare but life-threatening form of bleeding disorder, owing to the formation of auto-antibodies against FVIII. Treatment modalities include the use of immunosuppressive drugs such as cyclophosphamide and corticosteroids, plasmapheresis and i.v. immunoglobulin. A patient with idiopathic acquired FVIII inhibitor presented with serious bleeding complications resistant to all the above therapeutic modalities. Treatment with cyclosporin, however, resulted in a prompt and complete response. The lack of side-effects and the relatively quick response suggest that cyclosporin may be tried as front line treatment for patients with acquired FVIII inhibitors.
Persistent Identifierhttp://hdl.handle.net/10722/162762
ISSN
2015 Impact Factor: 2.673
2015 SCImago Journal Rankings: 1.138
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_US
dc.contributor.authorLam, CCKen_US
dc.contributor.authorKwong, YLen_US
dc.date.accessioned2012-09-05T05:23:10Z-
dc.date.available2012-09-05T05:23:10Z-
dc.date.issued2004en_US
dc.identifier.citationHaemophilia, 2004, v. 10 n. 1, p. 98-100en_US
dc.identifier.issn1351-8216en_US
dc.identifier.urihttp://hdl.handle.net/10722/162762-
dc.description.abstractAcquired factor VIII inhibitor causes a rare but life-threatening form of bleeding disorder, owing to the formation of auto-antibodies against FVIII. Treatment modalities include the use of immunosuppressive drugs such as cyclophosphamide and corticosteroids, plasmapheresis and i.v. immunoglobulin. A patient with idiopathic acquired FVIII inhibitor presented with serious bleeding complications resistant to all the above therapeutic modalities. Treatment with cyclosporin, however, resulted in a prompt and complete response. The lack of side-effects and the relatively quick response suggest that cyclosporin may be tried as front line treatment for patients with acquired FVIII inhibitors.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/HAEen_US
dc.relation.ispartofHaemophiliaen_US
dc.rightsHaemophilia. Copyright © Blackwell Publishing Ltd.-
dc.subject.meshAgeden_US
dc.subject.meshCyclosporine - Therapeutic Useen_US
dc.subject.meshDrug Resistanceen_US
dc.subject.meshHemophilia A - Drug Therapyen_US
dc.subject.meshHemorrhage - Drug Therapyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunosuppressive Agents - Therapeutic Useen_US
dc.subject.meshMaleen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleSuccessful treatment of acquired factor VIII inhibitor with cyclosporinen_US
dc.typeArticleen_US
dc.identifier.emailKwong, YL:ylkwong@hku.hken_US
dc.identifier.authorityKwong, YL=rp00358en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1046/j.1365-2516.2003.00837.x-
dc.identifier.pmid14962228-
dc.identifier.scopuseid_2-s2.0-1042280966en_US
dc.identifier.hkuros87928-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1042280966&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume10en_US
dc.identifier.issue1en_US
dc.identifier.spage98en_US
dc.identifier.epage100en_US
dc.identifier.isiWOS:000187892000015-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridAu, WY=7202383089en_US
dc.identifier.scopusauthoridLam, CCK=16947291300en_US
dc.identifier.scopusauthoridKwong, YL=7102818954en_US

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