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Article: Genomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong
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TitleGenomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong
 
AuthorsChim, SSC2
Tsui, SKW2
Chan, KCA2
Au, TCC2
Hung, ECW2
Tong, YK2
Chiu, RWK2
Ng, EKO2
Chan, PKS2
Chu, CM3
Sung, JJY2
Tam, JS2
Fung, KP2
Waye, MMY2
Lee, CY2
Yuen, KY1
Lo, YMD
 
Issue Date2003
 
PublisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lancet
 
CitationLancet, 2003, v. 362 n. 9398, p. 1807-1808 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0140-6736(03)14901-X
 
AbstractSevere acute respiratory syndrome (SARS) is a global health concern. In Hong Kong, two major outbreaks, one hospital based and the other in the Amoy Gardens apartments, were identified. The frequency of diarrhoea, admission to intensive care, and mortality differed significantly between the two outbreaks. We did genomic sequencing for viral isolates from five Amoy Gardens patients. The virus sequence was identical in four of these five patients. The sequence data from one hospital case and the four identical community cases had only three nucleotide differences. Alterations in the SARS coronavirus genome are unlikely to have caused the distinctive clinical features of the Amoy Gardens patients, and these results highlight the importance of non-viral genomic factors in this outbreak.
 
ISSN0140-6736
2012 Impact Factor: 39.06
2012 SCImago Journal Rankings: 7.074
 
DOIhttp://dx.doi.org/10.1016/S0140-6736(03)14901-X
 
ISI Accession Number IDWOS:000186872900013
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChim, SSC
 
dc.contributor.authorTsui, SKW
 
dc.contributor.authorChan, KCA
 
dc.contributor.authorAu, TCC
 
dc.contributor.authorHung, ECW
 
dc.contributor.authorTong, YK
 
dc.contributor.authorChiu, RWK
 
dc.contributor.authorNg, EKO
 
dc.contributor.authorChan, PKS
 
dc.contributor.authorChu, CM
 
dc.contributor.authorSung, JJY
 
dc.contributor.authorTam, JS
 
dc.contributor.authorFung, KP
 
dc.contributor.authorWaye, MMY
 
dc.contributor.authorLee, CY
 
dc.contributor.authorYuen, KY
 
dc.contributor.authorLo, YMD
 
dc.date.accessioned2012-08-08T08:49:30Z
 
dc.date.available2012-08-08T08:49:30Z
 
dc.date.issued2003
 
dc.description.abstractSevere acute respiratory syndrome (SARS) is a global health concern. In Hong Kong, two major outbreaks, one hospital based and the other in the Amoy Gardens apartments, were identified. The frequency of diarrhoea, admission to intensive care, and mortality differed significantly between the two outbreaks. We did genomic sequencing for viral isolates from five Amoy Gardens patients. The virus sequence was identical in four of these five patients. The sequence data from one hospital case and the four identical community cases had only three nucleotide differences. Alterations in the SARS coronavirus genome are unlikely to have caused the distinctive clinical features of the Amoy Gardens patients, and these results highlight the importance of non-viral genomic factors in this outbreak.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationLancet, 2003, v. 362 n. 9398, p. 1807-1808 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0140-6736(03)14901-X
 
dc.identifier.doihttp://dx.doi.org/10.1016/S0140-6736(03)14901-X
 
dc.identifier.epage1808
 
dc.identifier.isiWOS:000186872900013
 
dc.identifier.issn0140-6736
2012 Impact Factor: 39.06
2012 SCImago Journal Rankings: 7.074
 
dc.identifier.issue9398
 
dc.identifier.pmid14654320
 
dc.identifier.scopuseid_2-s2.0-10744223100
 
dc.identifier.spage1807
 
dc.identifier.urihttp://hdl.handle.net/10722/157383
 
dc.identifier.volume362
 
dc.languageeng
 
dc.publisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lancet
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofLancet
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshBase Sequence - Genetics
 
dc.subject.meshCross Infection - Virology
 
dc.subject.meshDisease Outbreaks - Statistics & Numerical Data
 
dc.subject.meshGenome, Viral
 
dc.subject.meshHong Kong - Epidemiology
 
dc.subject.meshHumans
 
dc.subject.meshSars Virus - Genetics
 
dc.subject.meshSevere Acute Respiratory Syndrome - Diagnosis - Epidemiology - Virology
 
dc.titleGenomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. Prince of Wales Hospital Hong Kong
  3. United Christian Hospital Hong Kong