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Article: Genomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong

TitleGenomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong
Authors
Issue Date2003
PublisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lancet
Citation
Lancet, 2003, v. 362 n. 9398, p. 1807-1808 How to Cite?
AbstractSevere acute respiratory syndrome (SARS) is a global health concern. In Hong Kong, two major outbreaks, one hospital based and the other in the Amoy Gardens apartments, were identified. The frequency of diarrhoea, admission to intensive care, and mortality differed significantly between the two outbreaks. We did genomic sequencing for viral isolates from five Amoy Gardens patients. The virus sequence was identical in four of these five patients. The sequence data from one hospital case and the four identical community cases had only three nucleotide differences. Alterations in the SARS coronavirus genome are unlikely to have caused the distinctive clinical features of the Amoy Gardens patients, and these results highlight the importance of non-viral genomic factors in this outbreak.
Persistent Identifierhttp://hdl.handle.net/10722/157383
ISSN
2014 Impact Factor: 45.217
2014 SCImago Journal Rankings: 11.150
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChim, SSCen_HK
dc.contributor.authorTsui, SKWen_HK
dc.contributor.authorChan, KCAen_HK
dc.contributor.authorAu, TCCen_HK
dc.contributor.authorHung, ECWen_HK
dc.contributor.authorTong, YKen_HK
dc.contributor.authorChiu, RWKen_HK
dc.contributor.authorNg, EKOen_HK
dc.contributor.authorChan, PKSen_HK
dc.contributor.authorChu, CMen_HK
dc.contributor.authorSung, JJYen_HK
dc.contributor.authorTam, JSen_HK
dc.contributor.authorFung, KPen_HK
dc.contributor.authorWaye, MMYen_HK
dc.contributor.authorLee, CYen_HK
dc.contributor.authorYuen, KYen_HK
dc.contributor.authorLo, YMDen_HK
dc.date.accessioned2012-08-08T08:49:30Z-
dc.date.available2012-08-08T08:49:30Z-
dc.date.issued2003en_HK
dc.identifier.citationLancet, 2003, v. 362 n. 9398, p. 1807-1808en_HK
dc.identifier.issn0140-6736en_HK
dc.identifier.urihttp://hdl.handle.net/10722/157383-
dc.description.abstractSevere acute respiratory syndrome (SARS) is a global health concern. In Hong Kong, two major outbreaks, one hospital based and the other in the Amoy Gardens apartments, were identified. The frequency of diarrhoea, admission to intensive care, and mortality differed significantly between the two outbreaks. We did genomic sequencing for viral isolates from five Amoy Gardens patients. The virus sequence was identical in four of these five patients. The sequence data from one hospital case and the four identical community cases had only three nucleotide differences. Alterations in the SARS coronavirus genome are unlikely to have caused the distinctive clinical features of the Amoy Gardens patients, and these results highlight the importance of non-viral genomic factors in this outbreak.en_HK
dc.languageengen_US
dc.publisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lanceten_HK
dc.relation.ispartofLanceten_HK
dc.subject.meshBase Sequence - Geneticsen_US
dc.subject.meshCross Infection - Virologyen_US
dc.subject.meshDisease Outbreaks - Statistics & Numerical Dataen_US
dc.subject.meshGenome, Viralen_US
dc.subject.meshHong Kong - Epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshSars Virus - Geneticsen_US
dc.subject.meshSevere Acute Respiratory Syndrome - Diagnosis - Epidemiology - Virologyen_US
dc.titleGenomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.emailNg, EKO: ngko@hku.hken_HK
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hken_HK
dc.identifier.authorityNg, EKO=rp01364en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0140-6736(03)14901-Xen_HK
dc.identifier.pmid14654320en_HK
dc.identifier.scopuseid_2-s2.0-10744223100en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-10744223100&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume362en_HK
dc.identifier.issue9398en_HK
dc.identifier.spage1807en_HK
dc.identifier.epage1808en_HK
dc.identifier.isiWOS:000186872900013-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChim, SSC=6701728226en_HK
dc.identifier.scopusauthoridTsui, SKW=7004961364en_HK
dc.identifier.scopusauthoridChan, KCA=13403797200en_HK
dc.identifier.scopusauthoridAu, TCC=55225059600en_HK
dc.identifier.scopusauthoridHung, ECW=7004256338en_HK
dc.identifier.scopusauthoridTong, YK=7202614141en_HK
dc.identifier.scopusauthoridChiu, RWK=7103038413en_HK
dc.identifier.scopusauthoridNg, EKO=21135553700en_HK
dc.identifier.scopusauthoridChan, PKS=7403497792en_HK
dc.identifier.scopusauthoridChu, CM=7404345558en_HK
dc.identifier.scopusauthoridSung, JJY=24473715000en_HK
dc.identifier.scopusauthoridTam, JS=24788939600en_HK
dc.identifier.scopusauthoridFung, KP=7202934739en_HK
dc.identifier.scopusauthoridWaye, MMY=7006687733en_HK
dc.identifier.scopusauthoridLee, CY=7410142857en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.scopusauthoridLo, YMD=7401935391en_HK

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