Article: Genomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong

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TitleGenomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong
AuthorsChim, SSC2
Tsui, SKW2
Chan, KCA2
Au, TCC2
Hung, ECW2
Tong, YK2
Chiu, RWK2
Ng, EKO2
Chan, PKS2
Chu, CM3
Sung, JJY2
Tam, JS2
Fung, KP2
Waye, MMY2
Lee, CY2
Yuen, KY1
Lo, YMD
Issue Date2003
PublisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lancet
CitationLancet, 2003, v. 362 n. 9398, p. 1807-1808 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0140-6736(03)14901-X
AbstractSevere acute respiratory syndrome (SARS) is a global health concern. In Hong Kong, two major outbreaks, one hospital based and the other in the Amoy Gardens apartments, were identified. The frequency of diarrhoea, admission to intensive care, and mortality differed significantly between the two outbreaks. We did genomic sequencing for viral isolates from five Amoy Gardens patients. The virus sequence was identical in four of these five patients. The sequence data from one hospital case and the four identical community cases had only three nucleotide differences. Alterations in the SARS coronavirus genome are unlikely to have caused the distinctive clinical features of the Amoy Gardens patients, and these results highlight the importance of non-viral genomic factors in this outbreak.
ISSN0140-6736
2011 Impact Factor: 38.278
2011 SCImago Journal Rankings: 1.486
DOIhttp://dx.doi.org/10.1016/S0140-6736(03)14901-X
ISI Accession Number IDWOS:000186872900013
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorChim, SSC
dc.contributor.authorTsui, SKW
dc.contributor.authorChan, KCA
dc.contributor.authorAu, TCC
dc.contributor.authorHung, ECW
dc.contributor.authorTong, YK
dc.contributor.authorChiu, RWK
dc.contributor.authorNg, EKO
dc.contributor.authorChan, PKS
dc.contributor.authorChu, CM
dc.contributor.authorSung, JJY
dc.contributor.authorTam, JS
dc.contributor.authorFung, KP
dc.contributor.authorWaye, MMY
dc.contributor.authorLee, CY
dc.contributor.authorYuen, KY
dc.contributor.authorLo, YMD
dc.date.accessioned2012-08-08T08:49:30Z
dc.date.available2012-08-08T08:49:30Z
dc.date.issued2003
dc.description.abstractSevere acute respiratory syndrome (SARS) is a global health concern. In Hong Kong, two major outbreaks, one hospital based and the other in the Amoy Gardens apartments, were identified. The frequency of diarrhoea, admission to intensive care, and mortality differed significantly between the two outbreaks. We did genomic sequencing for viral isolates from five Amoy Gardens patients. The virus sequence was identical in four of these five patients. The sequence data from one hospital case and the four identical community cases had only three nucleotide differences. Alterations in the SARS coronavirus genome are unlikely to have caused the distinctive clinical features of the Amoy Gardens patients, and these results highlight the importance of non-viral genomic factors in this outbreak.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationLancet, 2003, v. 362 n. 9398, p. 1807-1808 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0140-6736(03)14901-X
dc.identifier.doihttp://dx.doi.org/10.1016/S0140-6736(03)14901-X
dc.identifier.epage1808
dc.identifier.isiWOS:000186872900013
dc.identifier.issn0140-6736
2011 Impact Factor: 38.278
2011 SCImago Journal Rankings: 1.486
dc.identifier.issue9398
dc.identifier.pmid14654320
dc.identifier.scopuseid_2-s2.0-10744223100
dc.identifier.spage1807
dc.identifier.urihttp://hdl.handle.net/10722/157383
dc.identifier.volume362
dc.languageeng
dc.publisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lancet
dc.publisher.placeUnited Kingdom
dc.relation.ispartofLancet
dc.relation.referencesReferences in Scopus
dc.subject.meshBase Sequence - Genetics
dc.subject.meshCross Infection - Virology
dc.subject.meshDisease Outbreaks - Statistics & Numerical Data
dc.subject.meshGenome, Viral
dc.subject.meshHong Kong - Epidemiology
dc.subject.meshHumans
dc.subject.meshSars Virus - Genetics
dc.subject.meshSevere Acute Respiratory Syndrome - Diagnosis - Epidemiology - Virology
dc.titleGenomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Prince of Wales Hospital Hong Kong
  3. United Christian Hospital Hong Kong