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Article: Multivalent Antibiotics via Metal Complexes: Potent Divalent Vancomycins against Vancomycin-Resistant Enterococci

TitleMultivalent Antibiotics via Metal Complexes: Potent Divalent Vancomycins against Vancomycin-Resistant Enterococci
Authors
Issue Date2003
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/jmc
Citation
Journal Of Medicinal Chemistry, 2003, v. 46 n. 23, p. 4904-4909 How to Cite?
AbstractDimers of vancomycin (Van), linked by a rigid metal complex, [Pt(en)(H 2O) 2] 2+, exhibit potent activities (MIC ∼0.8 μg/mL, ∼720 times more potent than that of Van itself) against vancomycin-resistant enterococci (VRE). The result suggests that combining metal complexation and receptor/ligand interaction offers a useful method to construct multivalent inhibitors.
Persistent Identifierhttp://hdl.handle.net/10722/157372
ISSN
2015 Impact Factor: 5.589
2015 SCImago Journal Rankings: 2.529
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXing, Ben_US
dc.contributor.authorYu, CWen_US
dc.contributor.authorHo, PLen_US
dc.contributor.authorChow, KHen_US
dc.contributor.authorCheung, Ten_US
dc.contributor.authorGu, Hen_US
dc.contributor.authorCai, Zen_US
dc.contributor.authorXu, Ben_US
dc.date.accessioned2012-08-08T08:49:24Z-
dc.date.available2012-08-08T08:49:24Z-
dc.date.issued2003en_US
dc.identifier.citationJournal Of Medicinal Chemistry, 2003, v. 46 n. 23, p. 4904-4909en_US
dc.identifier.issn0022-2623en_US
dc.identifier.urihttp://hdl.handle.net/10722/157372-
dc.description.abstractDimers of vancomycin (Van), linked by a rigid metal complex, [Pt(en)(H 2O) 2] 2+, exhibit potent activities (MIC ∼0.8 μg/mL, ∼720 times more potent than that of Van itself) against vancomycin-resistant enterococci (VRE). The result suggests that combining metal complexation and receptor/ligand interaction offers a useful method to construct multivalent inhibitors.en_US
dc.languageengen_US
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/jmcen_US
dc.relation.ispartofJournal of Medicinal Chemistryen_US
dc.subject.meshAnti-Bacterial Agents - Chemical Synthesis - Pharmacologyen_US
dc.subject.meshDimerizationen_US
dc.subject.meshEnterococcus - Drug Effectsen_US
dc.subject.meshMagnetic Resonance Spectroscopyen_US
dc.subject.meshMicrobial Sensitivity Testsen_US
dc.subject.meshModels, Molecularen_US
dc.subject.meshMolecular Conformationen_US
dc.subject.meshOrganoplatinum Compounds - Chemical Synthesis - Pharmacologyen_US
dc.subject.meshSpectrometry, Mass, Electrospray Ionizationen_US
dc.subject.meshStructure-Activity Relationshipen_US
dc.subject.meshThermodynamicsen_US
dc.subject.meshVancomycin - Analogs & Derivatives - Chemical Synthesis - Pharmacologyen_US
dc.subject.meshVancomycin Resistanceen_US
dc.titleMultivalent Antibiotics via Metal Complexes: Potent Divalent Vancomycins against Vancomycin-Resistant Enterococcien_US
dc.typeArticleen_US
dc.identifier.emailHo, PL:plho@hkucc.hku.hken_US
dc.identifier.emailChow, KH:khchowb@hku.hken_US
dc.identifier.authorityHo, PL=rp00406en_US
dc.identifier.authorityChow, KH=rp00370en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid14584941-
dc.identifier.scopuseid_2-s2.0-0242331083en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0242331083&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume46en_US
dc.identifier.issue23en_US
dc.identifier.spage4904en_US
dc.identifier.epage4909en_US
dc.identifier.isiWOS:000186347400013-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridXing, B=7005212019en_US
dc.identifier.scopusauthoridYu, CW=55245202100en_US
dc.identifier.scopusauthoridHo, PL=7402211363en_US
dc.identifier.scopusauthoridChow, KH=7202180736en_US
dc.identifier.scopusauthoridCheung, T=7103334170en_US
dc.identifier.scopusauthoridGu, H=7402683197en_US
dc.identifier.scopusauthoridCai, Z=7402904946en_US
dc.identifier.scopusauthoridXu, B=24752310700en_US

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