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Article: Increased expression of matrix metalloproteinase 1 (MMP1) in 11 patients with patellar tendinosis

TitleIncreased expression of matrix metalloproteinase 1 (MMP1) in 11 patients with patellar tendinosis
Authors
Issue Date2002
Citation
Acta Orthopaedica Scandinavica, 2002, v. 73 n. 6, p. 658-662 How to Cite?
AbstractWe studied the expression of procollagen type I, matrix metalloproteinase 1 (MMP1) and tissue inhibitor of metalloproteinase 1 (TIMP-1) by immunohistochemistry in human patellar tendinosis tissues and healthy patellar tendons. In situ gelatin zymography was used to detect collagenolytic activities. The productions of MMP1, TIMP1 and gelatinolytic activities were compared in cell cultures from tendinosis samples and controls. Tendinosis tissues and cultures showed an increase in the expression level of MMP1 and a decrease in that of TIMP1, a condition favoring collagen degradation. Gelatinolytic activities in tendinosis tissues and cultures were elevated. Collagenolysis is a striking feature in patellar tendinosis.
Persistent Identifierhttp://hdl.handle.net/10722/156643
ISSN
2004 Impact Factor: 1.018
2008 SCImago Journal Rankings: 1.909
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFu, SCen_US
dc.contributor.authorChan, BPen_US
dc.contributor.authorWang, Wen_US
dc.contributor.authorPau, HMen_US
dc.contributor.authorChan, KMen_US
dc.contributor.authorRolf, CGen_US
dc.date.accessioned2012-08-08T08:43:21Z-
dc.date.available2012-08-08T08:43:21Z-
dc.date.issued2002en_US
dc.identifier.citationActa Orthopaedica Scandinavica, 2002, v. 73 n. 6, p. 658-662en_US
dc.identifier.issn0001-6470en_US
dc.identifier.urihttp://hdl.handle.net/10722/156643-
dc.description.abstractWe studied the expression of procollagen type I, matrix metalloproteinase 1 (MMP1) and tissue inhibitor of metalloproteinase 1 (TIMP-1) by immunohistochemistry in human patellar tendinosis tissues and healthy patellar tendons. In situ gelatin zymography was used to detect collagenolytic activities. The productions of MMP1, TIMP1 and gelatinolytic activities were compared in cell cultures from tendinosis samples and controls. Tendinosis tissues and cultures showed an increase in the expression level of MMP1 and a decrease in that of TIMP1, a condition favoring collagen degradation. Gelatinolytic activities in tendinosis tissues and cultures were elevated. Collagenolysis is a striking feature in patellar tendinosis.en_US
dc.languageengen_US
dc.relation.ispartofActa Orthopaedica Scandinavicaen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshCollagen Type I - Analysisen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMatrix Metalloproteinase 1 - Analysisen_US
dc.subject.meshPatella - Pathology - Physiopathologyen_US
dc.subject.meshProtease Inhibitors - Analysisen_US
dc.subject.meshTendinopathy - Pathology - Physiopathologyen_US
dc.subject.meshTendons - Pathology - Physiopathologyen_US
dc.subject.meshTissue Inhibitor Of Metalloproteinase-1 - Analysisen_US
dc.titleIncreased expression of matrix metalloproteinase 1 (MMP1) in 11 patients with patellar tendinosisen_US
dc.typeArticleen_US
dc.identifier.emailChan, BP:bpchan@hkucc.hku.hken_US
dc.identifier.authorityChan, BP=rp00087en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1080/000164702321039624en_US
dc.identifier.pmid12553513-
dc.identifier.scopuseid_2-s2.0-0036908750en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036908750&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume73en_US
dc.identifier.issue6en_US
dc.identifier.spage658en_US
dc.identifier.epage662en_US
dc.identifier.isiWOS:000180091200010-
dc.identifier.scopusauthoridFu, SC=7402732268en_US
dc.identifier.scopusauthoridChan, BP=7201530390en_US
dc.identifier.scopusauthoridWang, W=38262127700en_US
dc.identifier.scopusauthoridPau, HM=7102371880en_US
dc.identifier.scopusauthoridChan, KM=7406034671en_US
dc.identifier.scopusauthoridRolf, CG=8558587900en_US

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