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Article: Adolescent escitalopram administration modifies neurochemical alterations in the hippocampus of maternally separated rats

TitleAdolescent escitalopram administration modifies neurochemical alterations in the hippocampus of maternally separated rats
Authors
Issue Date2010
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/euroneuro
Citation
European Neuropsychopharmacology, 2010, v. 20 n. 12, p. 875-883 How to Cite?
AbstractEarly life stress is a potential precursor of eventual neuropsychiatric diseases and may result in altered neurodevelopment and function of the hippocampus, which thus provides a site at which potential interventions to modify the effects of early life stress may act. In this study, Sprague-Dawley rat pups comprising male and female animals underwent maternal separation (MS) for 180min from postnatal days (PND) 2 to 14, or were left with their dams. They subsequently received daily administration of saline (0.9%), escitalopram (10mg/kg), or no treatment during adolescence (PND 43-60). All adult animals underwent brain magnetic resonance imaging (MRI) and bilateral hippocampal proton magnetic resonance spectroscopy ( 1H-MRS). Neither MS nor escitalopram treatment had a significant effect on hippocampal volume. Adult rats that experienced MS displayed significantly increased choline-containing compounds (Cho) and decreased N-acetylaspartate (NAA), glutamate (Glu) and Myo-inositol (MI) relative to the stable neurometabolite creatine (Cr) in hippocampus. Administration of escitalopram during adolescence could modify the alterations of NAA/Cr, Glu/Cr and MI/Cr. The effects of MS on hippocampal neurochemistry were most significant in the right hippocampus. These results indicate that MS in rats has long-term consequences on hippocampal neurochemistry reflective of neural density/functional integrity, especially on the right hippocampus, and adolescent administration with escitalopram can at least partially ameliorate these neurochemical alterations. Furthermore, these metabolite changes seem to be more sensitive indicators of the results from early life stress than volume changes. © 2010 Elsevier B.V.
Persistent Identifierhttp://hdl.handle.net/10722/155587
ISSN
2015 Impact Factor: 4.409
2015 SCImago Journal Rankings: 1.851
ISI Accession Number ID
Funding AgencyGrant Number
National Natural Science Foundation of China30770779
30825014
30830046
National Basic Research Program of China (973 Program)2007CB512308
2009CB918303
National Hi-Tech Research and Development Program of China (863 Program)2008AA02Z413
Funding Information:

This research was partly supported by National Natural Science Foundation of China (No. 30770779 and No. 30825014 to Zhijun Zhang; No. 30830046 to Lingjiang Li), National Basic Research Program of China (973 Program) (No. 2007CB512308 to Zhijun Zhang; No. 2009CB918303 to Lingjiang Li) and National Hi-Tech Research and Development Program of China (863 Program) (No. 2008AA02Z413 to Zhijun Zhang).

References

 

DC FieldValueLanguage
dc.contributor.authorHui, Jen_US
dc.contributor.authorZhang, Zen_US
dc.contributor.authorLiu, Sen_US
dc.contributor.authorXi, Gen_US
dc.contributor.authorZhang, Xen_US
dc.contributor.authorTeng, Gen_US
dc.contributor.authorChan, KCen_US
dc.contributor.authorWu, EXen_US
dc.contributor.authorNie, Ben_US
dc.contributor.authorShan, Ben_US
dc.contributor.authorLi, Len_US
dc.contributor.authorReynolds, GPen_US
dc.date.accessioned2012-08-08T08:34:13Z-
dc.date.available2012-08-08T08:34:13Z-
dc.date.issued2010en_US
dc.identifier.citationEuropean Neuropsychopharmacology, 2010, v. 20 n. 12, p. 875-883en_US
dc.identifier.issn0924-977Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/155587-
dc.description.abstractEarly life stress is a potential precursor of eventual neuropsychiatric diseases and may result in altered neurodevelopment and function of the hippocampus, which thus provides a site at which potential interventions to modify the effects of early life stress may act. In this study, Sprague-Dawley rat pups comprising male and female animals underwent maternal separation (MS) for 180min from postnatal days (PND) 2 to 14, or were left with their dams. They subsequently received daily administration of saline (0.9%), escitalopram (10mg/kg), or no treatment during adolescence (PND 43-60). All adult animals underwent brain magnetic resonance imaging (MRI) and bilateral hippocampal proton magnetic resonance spectroscopy ( 1H-MRS). Neither MS nor escitalopram treatment had a significant effect on hippocampal volume. Adult rats that experienced MS displayed significantly increased choline-containing compounds (Cho) and decreased N-acetylaspartate (NAA), glutamate (Glu) and Myo-inositol (MI) relative to the stable neurometabolite creatine (Cr) in hippocampus. Administration of escitalopram during adolescence could modify the alterations of NAA/Cr, Glu/Cr and MI/Cr. The effects of MS on hippocampal neurochemistry were most significant in the right hippocampus. These results indicate that MS in rats has long-term consequences on hippocampal neurochemistry reflective of neural density/functional integrity, especially on the right hippocampus, and adolescent administration with escitalopram can at least partially ameliorate these neurochemical alterations. Furthermore, these metabolite changes seem to be more sensitive indicators of the results from early life stress than volume changes. © 2010 Elsevier B.V.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/euroneuroen_US
dc.relation.ispartofEuropean Neuropsychopharmacologyen_US
dc.subject.meshAge Factorsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnimals, Newbornen_US
dc.subject.meshCitalopram - Administration & Dosageen_US
dc.subject.meshFemaleen_US
dc.subject.meshHippocampus - Chemistry - Drug Effects - Metabolismen_US
dc.subject.meshMagnetic Resonance Imaging - Methodsen_US
dc.subject.meshMaleen_US
dc.subject.meshMaternal Deprivationen_US
dc.subject.meshOrgan Sizeen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.titleAdolescent escitalopram administration modifies neurochemical alterations in the hippocampus of maternally separated ratsen_US
dc.typeArticleen_US
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_US
dc.identifier.authorityWu, EX=rp00193en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.euroneuro.2010.08.010en_US
dc.identifier.pmid20888191-
dc.identifier.scopuseid_2-s2.0-77958180396en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77958180396&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume20en_US
dc.identifier.issue12en_US
dc.identifier.spage875en_US
dc.identifier.epage883en_US
dc.identifier.isiWOS:000284569600006-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridHui, J=36573527000en_US
dc.identifier.scopusauthoridZhang, Z=15081680700en_US
dc.identifier.scopusauthoridLiu, S=36573843100en_US
dc.identifier.scopusauthoridXi, G=23669525900en_US
dc.identifier.scopusauthoridZhang, X=8232450000en_US
dc.identifier.scopusauthoridTeng, G=7004411906en_US
dc.identifier.scopusauthoridChan, KC=34968940300en_US
dc.identifier.scopusauthoridWu, EX=7202128034en_US
dc.identifier.scopusauthoridNie, B=28267940200en_US
dc.identifier.scopusauthoridShan, B=7006926463en_US
dc.identifier.scopusauthoridLi, L=35115169500en_US
dc.identifier.scopusauthoridReynolds, GP=7201487920en_US
dc.identifier.citeulike7974717-

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