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Article: An experimental gingivitis study to evaluate the clinical effects of a stannous fluoride dentifrice.
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TitleAn experimental gingivitis study to evaluate the clinical effects of a stannous fluoride dentifrice.
 
AuthorsLang, NP1
Anton, E1
Gabriel, Y1
Salvi, GE1
Pjetursson, BE1
Winston, JL1
He, T1
 
Issue Date2004
 
PublisherQuintessence Publishing Co Ltd. The Journal's web site is located at http://www.quintessencepublishing.co.uk/catalog/product_info.php?cPath=3&products_id=239
 
CitationOral Health & Preventive Dentistry, 2004, v. 2 n. 4, p. 369-376 [How to Cite?]
 
AbstractPURPOSE: A double blind, controlled, parallel group trial utilizing the experimental gingivitis model was performed on thirty young adults to evaluate the clinical effects of a 0.45% stannous fluoride dentifrice used as a slurry on dental biofilm formation and the development of gingivitis. MATERIAL AND METHODS: Following a thorough examination and oral prophylaxis procedures, subjects were randomly assigned to apply one of the following dentifrices twice daily over a three-week period: A) dentifrice slurry without active ingredients; B) 0.45% stannous fluoride gel; and C) Colgate Total dentifrice slurry (0.30% triclosan, 0.24% sodium fluoride, 2% copolymer). RESULTS: After three weeks, the stannous fluoride dentifrice significantly (p < 0.05) reduced gingivitis compared with the Colgate Total group by 39.7%. Gingival bleeding was also reduced relative to the Colgate Total group. This difference was statistically significant (P < 0.05). During the experimental period, the mean PII scores increased almost linearly in all three groups without yielding any statistically significant differences. CONCLUSIONS: The results of this clinical trial demonstrated that, over a three-week period, the application of a 0.45% SnF2 gel significantly inhibited the onset of gingivitis compared to Triclosan/sodium fluoride/copolymer (Colgate Total). However, neither stannous fluoride nor Triclosan/sodium fluoride/ copolymer (Colgate Total) possessed sufficient antimicrobial activity to suppress biofilm formation in the absence of regular oral hygiene practices.
 
ISSN1602-1622
2013 Impact Factor: 0.532
2013 SCImago Journal Rankings: 0.369
 
DC FieldValue
dc.contributor.authorLang, NP
 
dc.contributor.authorAnton, E
 
dc.contributor.authorGabriel, Y
 
dc.contributor.authorSalvi, GE
 
dc.contributor.authorPjetursson, BE
 
dc.contributor.authorWinston, JL
 
dc.contributor.authorHe, T
 
dc.date.accessioned2012-08-08T08:25:00Z
 
dc.date.available2012-08-08T08:25:00Z
 
dc.date.issued2004
 
dc.description.abstractPURPOSE: A double blind, controlled, parallel group trial utilizing the experimental gingivitis model was performed on thirty young adults to evaluate the clinical effects of a 0.45% stannous fluoride dentifrice used as a slurry on dental biofilm formation and the development of gingivitis. MATERIAL AND METHODS: Following a thorough examination and oral prophylaxis procedures, subjects were randomly assigned to apply one of the following dentifrices twice daily over a three-week period: A) dentifrice slurry without active ingredients; B) 0.45% stannous fluoride gel; and C) Colgate Total dentifrice slurry (0.30% triclosan, 0.24% sodium fluoride, 2% copolymer). RESULTS: After three weeks, the stannous fluoride dentifrice significantly (p < 0.05) reduced gingivitis compared with the Colgate Total group by 39.7%. Gingival bleeding was also reduced relative to the Colgate Total group. This difference was statistically significant (P < 0.05). During the experimental period, the mean PII scores increased almost linearly in all three groups without yielding any statistically significant differences. CONCLUSIONS: The results of this clinical trial demonstrated that, over a three-week period, the application of a 0.45% SnF2 gel significantly inhibited the onset of gingivitis compared to Triclosan/sodium fluoride/copolymer (Colgate Total). However, neither stannous fluoride nor Triclosan/sodium fluoride/ copolymer (Colgate Total) possessed sufficient antimicrobial activity to suppress biofilm formation in the absence of regular oral hygiene practices.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationOral Health & Preventive Dentistry, 2004, v. 2 n. 4, p. 369-376 [How to Cite?]
 
dc.identifier.epage376
 
dc.identifier.issn1602-1622
2013 Impact Factor: 0.532
2013 SCImago Journal Rankings: 0.369
 
dc.identifier.issue4
 
dc.identifier.pmid16296255
 
dc.identifier.scopuseid_2-s2.0-33644631289
 
dc.identifier.spage369
 
dc.identifier.urihttp://hdl.handle.net/10722/154384
 
dc.identifier.volume2
 
dc.languageeng
 
dc.publisherQuintessence Publishing Co Ltd. The Journal's web site is located at http://www.quintessencepublishing.co.uk/catalog/product_info.php?cPath=3&products_id=239
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofOral health & preventive dentistry
 
dc.subject.meshAdult
 
dc.subject.meshComplex Mixtures - Therapeutic Use
 
dc.subject.meshDental Plaque - Prevention & Control
 
dc.subject.meshDental Plaque Index
 
dc.subject.meshDentifrices - Therapeutic Use
 
dc.subject.meshDouble-Blind Method
 
dc.subject.meshFemale
 
dc.subject.meshFluorides - Therapeutic Use
 
dc.subject.meshGingivitis - Prevention & Control
 
dc.subject.meshHumans
 
dc.subject.meshMale
 
dc.subject.meshPeriodontal Index
 
dc.subject.meshSilicic Acid
 
dc.subject.meshTin Fluorides - Therapeutic Use
 
dc.subject.meshToothpastes
 
dc.subject.meshTriclosan - Therapeutic Use
 
dc.titleAn experimental gingivitis study to evaluate the clinical effects of a stannous fluoride dentifrice.
 
dc.typeArticle
 
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<item><contributor.author>Lang, NP</contributor.author>
<contributor.author>Anton, E</contributor.author>
<contributor.author>Gabriel, Y</contributor.author>
<contributor.author>Salvi, GE</contributor.author>
<contributor.author>Pjetursson, BE</contributor.author>
<contributor.author>Winston, JL</contributor.author>
<contributor.author>He, T</contributor.author>
<date.accessioned>2012-08-08T08:25:00Z</date.accessioned>
<date.available>2012-08-08T08:25:00Z</date.available>
<date.issued>2004</date.issued>
<identifier.citation>Oral Health &amp; Preventive Dentistry, 2004, v. 2 n. 4, p. 369-376</identifier.citation>
<identifier.issn>1602-1622</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/154384</identifier.uri>
<description.abstract>PURPOSE: A double blind, controlled, parallel group trial utilizing the experimental gingivitis model was performed on thirty young adults to evaluate the clinical effects of a 0.45% stannous fluoride dentifrice used as a slurry on dental biofilm formation and the development of gingivitis. MATERIAL AND METHODS: Following a thorough examination and oral prophylaxis procedures, subjects were randomly assigned to apply one of the following dentifrices twice daily over a three-week period: A) dentifrice slurry without active ingredients; B) 0.45% stannous fluoride gel; and C) Colgate Total dentifrice slurry (0.30% triclosan, 0.24% sodium fluoride, 2% copolymer). RESULTS: After three weeks, the stannous fluoride dentifrice significantly (p &lt; 0.05) reduced gingivitis compared with the Colgate Total group by 39.7%. Gingival bleeding was also reduced relative to the Colgate Total group. This difference was statistically significant (P &lt; 0.05). During the experimental period, the mean PII scores increased almost linearly in all three groups without yielding any statistically significant differences. CONCLUSIONS: The results of this clinical trial demonstrated that, over a three-week period, the application of a 0.45% SnF2 gel significantly inhibited the onset of gingivitis compared to Triclosan/sodium fluoride/copolymer (Colgate Total). However, neither stannous fluoride nor Triclosan/sodium fluoride/ copolymer (Colgate Total) possessed sufficient antimicrobial activity to suppress biofilm formation in the absence of regular oral hygiene practices.</description.abstract>
<language>eng</language>
<publisher>Quintessence Publishing Co Ltd. The Journal&apos;s web site is located at http://www.quintessencepublishing.co.uk/catalog/product_info.php?cPath=3&amp;products_id=239</publisher>
<relation.ispartof>Oral health &amp; preventive dentistry</relation.ispartof>
<subject.mesh>Adult</subject.mesh>
<subject.mesh>Complex Mixtures - Therapeutic Use</subject.mesh>
<subject.mesh>Dental Plaque - Prevention &amp; Control</subject.mesh>
<subject.mesh>Dental Plaque Index</subject.mesh>
<subject.mesh>Dentifrices - Therapeutic Use</subject.mesh>
<subject.mesh>Double-Blind Method</subject.mesh>
<subject.mesh>Female</subject.mesh>
<subject.mesh>Fluorides - Therapeutic Use</subject.mesh>
<subject.mesh>Gingivitis - Prevention &amp; Control</subject.mesh>
<subject.mesh>Humans</subject.mesh>
<subject.mesh>Male</subject.mesh>
<subject.mesh>Periodontal Index</subject.mesh>
<subject.mesh>Silicic Acid</subject.mesh>
<subject.mesh>Tin Fluorides - Therapeutic Use</subject.mesh>
<subject.mesh>Toothpastes</subject.mesh>
<subject.mesh>Triclosan - Therapeutic Use</subject.mesh>
<title>An experimental gingivitis study to evaluate the clinical effects of a stannous fluoride dentifrice.</title>
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<identifier.pmid>16296255</identifier.pmid>
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<identifier.volume>2</identifier.volume>
<identifier.issue>4</identifier.issue>
<identifier.spage>369</identifier.spage>
<identifier.epage>376</identifier.epage>
<publisher.place>United Kingdom</publisher.place>
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Author Affiliations
  1. Universität Bern