File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: In vivo cancellous bone remodeling on a Strontium-containing hydroxyapatite (Sr-HA) bioactive cement

TitleIn vivo cancellous bone remodeling on a Strontium-containing hydroxyapatite (Sr-HA) bioactive cement
Authors
KeywordsBioactive bone cement
Bone formation
Bone remodeling
Osteoconductive
Strontium-containing hydroxyapatite
Issue Date2004
Citation
Journal Of Biomedical Materials Research - Part A, 2004, v. 68 n. 3, p. 513-521 How to Cite?
AbstractThe purpose of this study was to investigate the in vivo bone response to the strontium-containing hydroxyapatite (Sr-HA) bioactive bone cement injected into the cancellous bone. Sr-HA cement was injected into the iliac crest of rabbits for 1, 3, and 6 months. Active bone formation and remodeling were observed after 1 month. Newly formed bone was observed to grow onto the bone cement after 3 months. Thick osteoid layer with osteoblasts formed along the bone and guided over the bone cement surface reflected the stimulating effect of Sr-HA. From scanning electron microscopy (SEM) and energy-dispersive X-ray (EDX) analysis, high calcium and phosphorus levels were detected at the interface with a thick layer of 70 μm in width, and fusion of Sr-HA with the bone was observed. Blood vessels were found developing in remodeling sites. The affinity of bone on Sr-HA cement was increased from 73.55 ± 3.50% after 3 months up to 85.15 ± 2.74% after 6 months (p < 0.01). In contrast to Sr-HA cement, poly(methyl methacrylate) (PMMA) bone cement was neither osteoconductive nor bioresorbable. Results show that the Sr-HA cement is biocompatible and osteoconductive, which is suitable for use in treating osteoporotic vertebral fractures. © 2003 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/154292
ISSN
2004 Impact Factor: 3.652
2006 SCImago Journal Rankings: 0.474
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, CTen_HK
dc.contributor.authorLu, WWen_HK
dc.contributor.authorChan, WKen_HK
dc.contributor.authorCheung, KMCen_HK
dc.contributor.authorLuk, KDKen_HK
dc.contributor.authorLu, DSen_HK
dc.contributor.authorRabie, ABMen_HK
dc.contributor.authorDeng, LFen_HK
dc.contributor.authorLeong, JCYen_HK
dc.date.accessioned2012-08-08T08:24:26Z-
dc.date.available2012-08-08T08:24:26Z-
dc.date.issued2004en_HK
dc.identifier.citationJournal Of Biomedical Materials Research - Part A, 2004, v. 68 n. 3, p. 513-521en_HK
dc.identifier.issn0021-9304en_HK
dc.identifier.urihttp://hdl.handle.net/10722/154292-
dc.description.abstractThe purpose of this study was to investigate the in vivo bone response to the strontium-containing hydroxyapatite (Sr-HA) bioactive bone cement injected into the cancellous bone. Sr-HA cement was injected into the iliac crest of rabbits for 1, 3, and 6 months. Active bone formation and remodeling were observed after 1 month. Newly formed bone was observed to grow onto the bone cement after 3 months. Thick osteoid layer with osteoblasts formed along the bone and guided over the bone cement surface reflected the stimulating effect of Sr-HA. From scanning electron microscopy (SEM) and energy-dispersive X-ray (EDX) analysis, high calcium and phosphorus levels were detected at the interface with a thick layer of 70 μm in width, and fusion of Sr-HA with the bone was observed. Blood vessels were found developing in remodeling sites. The affinity of bone on Sr-HA cement was increased from 73.55 ± 3.50% after 3 months up to 85.15 ± 2.74% after 6 months (p < 0.01). In contrast to Sr-HA cement, poly(methyl methacrylate) (PMMA) bone cement was neither osteoconductive nor bioresorbable. Results show that the Sr-HA cement is biocompatible and osteoconductive, which is suitable for use in treating osteoporotic vertebral fractures. © 2003 Wiley Periodicals, Inc.en_HK
dc.languageengen_US
dc.relation.ispartofJournal of Biomedical Materials Research - Part Aen_HK
dc.rightsJournal of Biomedical Materials Research Part A. Copyright © John Wiley & Sons, Inc.-
dc.subjectBioactive bone cementen_HK
dc.subjectBone formationen_HK
dc.subjectBone remodelingen_HK
dc.subjectOsteoconductiveen_HK
dc.subjectStrontium-containing hydroxyapatiteen_HK
dc.subject.meshAnimalsen_US
dc.subject.meshBiodegradation, Environmentalen_US
dc.subject.meshBone Cements - Chemistry - Pharmacology - Standardsen_US
dc.subject.meshBone Remodeling - Drug Effectsen_US
dc.subject.meshDurapatiteen_US
dc.subject.meshIliumen_US
dc.subject.meshMaterials Testingen_US
dc.subject.meshNeovascularization, Physiologic - Drug Effectsen_US
dc.subject.meshOsteoblasts - Cytology - Drug Effectsen_US
dc.subject.meshPolymethyl Methacrylateen_US
dc.subject.meshRabbitsen_US
dc.subject.meshStrontiumen_US
dc.titleIn vivo cancellous bone remodeling on a Strontium-containing hydroxyapatite (Sr-HA) bioactive cementen_HK
dc.typeArticleen_HK
dc.identifier.emailLu, WW: wwlu@hku.hken_HK
dc.identifier.emailChan, WK: waichan@hku.hken_HK
dc.identifier.emailCheung, KMC: cheungmc@hku.hken_HK
dc.identifier.emailLuk, KDK: hcm21000@hku.hken_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.authorityLu, WW=rp00411en_HK
dc.identifier.authorityChan, WK=rp00667en_HK
dc.identifier.authorityCheung, KMC=rp00387en_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/jbm.a.20089-
dc.identifier.pmid14762931-
dc.identifier.scopuseid_2-s2.0-1342301648en_HK
dc.identifier.hkuros87297-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1342301648&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume68en_HK
dc.identifier.issue3en_HK
dc.identifier.spage513en_HK
dc.identifier.epage521en_HK
dc.identifier.isiWOS:000189011800013-
dc.identifier.scopusauthoridWong, CT=7404954512en_HK
dc.identifier.scopusauthoridLu, WW=7404215221en_HK
dc.identifier.scopusauthoridChan, WK=13310083000en_HK
dc.identifier.scopusauthoridCheung, KMC=7402406754en_HK
dc.identifier.scopusauthoridLuk, KDK=7201921573en_HK
dc.identifier.scopusauthoridLu, DS=7403079533en_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK
dc.identifier.scopusauthoridDeng, LF=7202007494en_HK
dc.identifier.scopusauthoridLeong, JCY=35560782200en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats