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Article: The Correlation between Neovascularization and Bone Formation in the Condyle during Forward Mandibular Positioning

TitleThe Correlation between Neovascularization and Bone Formation in the Condyle during Forward Mandibular Positioning
Authors
KeywordsFunctional appliance therapy
Mandibular condylar growth
New bone formation
Vascular Endothelial Growth Factor
Vascularization
Issue Date2002
PublisherE H Angle Education and Research Foundation, Inc. The Journal's web site is located at http://www.angle.org/
Citation
Angle Orthodontist, 2002, v. 72 n. 5, p. 431-438 How to Cite?
AbstractThe aim of the present study was to investigate the temporal pattern of expression of VEGF (Vascular Endothelial Growth Factor) and new bone formation in the condyle during forward mandibular positioning. The importance of vascularization during endochondral ossification was investigated during natural growth of the condyle and compared to that after forward mandibular positioning. The goal was to further our understanding of the cellular responses during functional appliance therapy with a view to extending the experiment into maturity. One hundred and fifty 35 days old Sprage-Dawley rats, 100 fitted with a bite-jumping appliance and 50 untreated, were divided into 10 groups. One group was sacrificed on each of experimental days 3, 7, 14, 21, 30, 33, 37, 44, 51 and 60 respectively. Sagittal sections were cut and stained with VEGF antibodies and Periodic acid and Schiff's reagent (PAS). Each section was quantitatively analyzed with a computer assisted analyzing program and the temporal sequence of expression of VEGF and new bone formation during natural growth and after mandibular forward positioning was compared. There was significant increase in both vascularization and mandibular bone growth upon forward mandibular positioning and the highest amount of both were expressed in the posterior region of the condyle. The highest acceleration of vascularization preceded that of new bone formation. Thus, forward mandibular positioning was found to solicit a sequence of cellular events leading to increased vascularization and subsequently new bone formation resulting in enhanced condylar growth.
Persistent Identifierhttp://hdl.handle.net/10722/154213
ISSN
2015 Impact Factor: 1.579
2015 SCImago Journal Rankings: 1.254
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorRabie, ABMen_HK
dc.contributor.authorLeung, FYCen_HK
dc.contributor.authorChayanupatkul, Aen_HK
dc.contributor.authorHägg, Uen_HK
dc.date.accessioned2012-08-08T08:23:55Z-
dc.date.available2012-08-08T08:23:55Z-
dc.date.issued2002en_HK
dc.identifier.citationAngle Orthodontist, 2002, v. 72 n. 5, p. 431-438en_HK
dc.identifier.issn0003-3219en_HK
dc.identifier.urihttp://hdl.handle.net/10722/154213-
dc.description.abstractThe aim of the present study was to investigate the temporal pattern of expression of VEGF (Vascular Endothelial Growth Factor) and new bone formation in the condyle during forward mandibular positioning. The importance of vascularization during endochondral ossification was investigated during natural growth of the condyle and compared to that after forward mandibular positioning. The goal was to further our understanding of the cellular responses during functional appliance therapy with a view to extending the experiment into maturity. One hundred and fifty 35 days old Sprage-Dawley rats, 100 fitted with a bite-jumping appliance and 50 untreated, were divided into 10 groups. One group was sacrificed on each of experimental days 3, 7, 14, 21, 30, 33, 37, 44, 51 and 60 respectively. Sagittal sections were cut and stained with VEGF antibodies and Periodic acid and Schiff's reagent (PAS). Each section was quantitatively analyzed with a computer assisted analyzing program and the temporal sequence of expression of VEGF and new bone formation during natural growth and after mandibular forward positioning was compared. There was significant increase in both vascularization and mandibular bone growth upon forward mandibular positioning and the highest amount of both were expressed in the posterior region of the condyle. The highest acceleration of vascularization preceded that of new bone formation. Thus, forward mandibular positioning was found to solicit a sequence of cellular events leading to increased vascularization and subsequently new bone formation resulting in enhanced condylar growth.en_HK
dc.languageengen_US
dc.publisherE H Angle Education and Research Foundation, Inc. The Journal's web site is located at http://www.angle.org/en_HK
dc.relation.ispartofAngle Orthodontisten_HK
dc.subjectFunctional appliance therapyen_HK
dc.subjectMandibular condylar growthen_HK
dc.subjectNew bone formationen_HK
dc.subjectVascular Endothelial Growth Factoren_HK
dc.subjectVascularizationen_HK
dc.subject.meshAnalysis Of Varianceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshChondrocytes - Pathologyen_US
dc.subject.meshEndothelial Growth Factors - Analysisen_US
dc.subject.meshFemaleen_US
dc.subject.meshImage Processing, Computer-Assisteden_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshIntercellular Signaling Peptides And Proteins - Analysisen_US
dc.subject.meshLymphokines - Analysisen_US
dc.subject.meshMandible - Growth & Development - Pathology - Physiologyen_US
dc.subject.meshMandibular Condyle - Blood Supply - Growth & Development - Physiologyen_US
dc.subject.meshNeovascularization, Physiologic - Physiologyen_US
dc.subject.meshOrthodontic Appliance Designen_US
dc.subject.meshOrthodontic Appliances, Functionalen_US
dc.subject.meshOsteogenesis - Physiologyen_US
dc.subject.meshPeriodic Acid-Schiff Reactionen_US
dc.subject.meshProtein Isoforms - Analysisen_US
dc.subject.meshRandom Allocationen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshStatistics As Topicen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshVascular Endothelial Growth Factor Aen_US
dc.subject.meshVascular Endothelial Growth Factorsen_US
dc.titleThe Correlation between Neovascularization and Bone Formation in the Condyle during Forward Mandibular Positioningen_HK
dc.typeArticleen_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.emailHägg, U: euohagg@hkusua.hku.hken_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.identifier.authorityHägg, U=rp00020en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid12401052-
dc.identifier.scopuseid_2-s2.0-0036777013en_HK
dc.identifier.hkuros76138-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036777013&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume72en_HK
dc.identifier.issue5en_HK
dc.identifier.spage431en_HK
dc.identifier.epage438en_HK
dc.identifier.isiWOS:000178708300011-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK
dc.identifier.scopusauthoridLeung, FYC=36103875400en_HK
dc.identifier.scopusauthoridChayanupatkul, A=6506338362en_HK
dc.identifier.scopusauthoridHägg, U=7006790279en_HK

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