Article: Ultrastructural identification of cells involved in the healing of intramembranous bone grafts in both the presence and absence of demineralised intramembranous bone matrix.

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TitleUltrastructural identification of cells involved in the healing of intramembranous bone grafts in both the presence and absence of demineralised intramembranous bone matrix.
AuthorsChay, SH1
Rabie, AB1
Itthagarun, A1
Issue Date2000
CitationAustralian Orthodontic Journal, 2000, v. 16 n. 2, p. 88-97 [How to Cite?]
AbstractAlveolar bone defects are conditions that impede the progress of orthodontic treatment. This study compared the mechanics of the healing of autogenous intramembranous (IM) bone grafts and grafts comprising a mixture of IM and demineralised bone matrix of autogenous intramembranous origin (DBMIM), in an attempt to determine the reliability of each material. Thirty-two New Zealand white rabbits had a single defect created in their skull. Sixteen were grafted with IM bone alone (Group I: autogenous IM), and the other 16 had a combined graft of composite IM sandwiched between two layers of DBMIM (Group II: composite IM-DBMIM). A third group (Group III) of eight rabbits each had two defects created in their skull; one defect was left empty (A: passive control) and the other filled with rabbit-skin collagen (B: active control). In Groups I and II, inflammatory cells were found to be present on Days 1 and 2 of tissue retrieval. The appearance of the mesenchymal cells and preosteoblasts, osteoblasts and osteocytes was earlier (Day 3) in Group II than in Group I (Day 5). In both groups, preosteoblasts, osteoblasts and osteocytes were observed with no cartilage at the intermediate stage. In conclusion, autogenous IM bone grafts and IM bone grafts in the presence of DBMIM healed through an osteogenic ossification route.
ISSN0587-3908
2011 Impact Factor: 0.25
2011 SCImago Journal Rankings: 0.035
DC Field
Value
dc.contributor.authorChay, SH
dc.contributor.authorRabie, AB
dc.contributor.authorItthagarun, A
dc.date.accessioned2012-08-08T08:23:18Z
dc.date.available2012-08-08T08:23:18Z
dc.date.issued2000
dc.description.abstractAlveolar bone defects are conditions that impede the progress of orthodontic treatment. This study compared the mechanics of the healing of autogenous intramembranous (IM) bone grafts and grafts comprising a mixture of IM and demineralised bone matrix of autogenous intramembranous origin (DBMIM), in an attempt to determine the reliability of each material. Thirty-two New Zealand white rabbits had a single defect created in their skull. Sixteen were grafted with IM bone alone (Group I: autogenous IM), and the other 16 had a combined graft of composite IM sandwiched between two layers of DBMIM (Group II: composite IM-DBMIM). A third group (Group III) of eight rabbits each had two defects created in their skull; one defect was left empty (A: passive control) and the other filled with rabbit-skin collagen (B: active control). In Groups I and II, inflammatory cells were found to be present on Days 1 and 2 of tissue retrieval. The appearance of the mesenchymal cells and preosteoblasts, osteoblasts and osteocytes was earlier (Day 3) in Group II than in Group I (Day 5). In both groups, preosteoblasts, osteoblasts and osteocytes were observed with no cartilage at the intermediate stage. In conclusion, autogenous IM bone grafts and IM bone grafts in the presence of DBMIM healed through an osteogenic ossification route.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationAustralian Orthodontic Journal, 2000, v. 16 n. 2, p. 88-97 [How to Cite?]
dc.identifier.epage97
dc.identifier.issn0587-3908
2011 Impact Factor: 0.25
2011 SCImago Journal Rankings: 0.035
dc.identifier.issue2
dc.identifier.pmid11201969
dc.identifier.scopuseid_2-s2.0-0034231807
dc.identifier.spage88
dc.identifier.urihttp://hdl.handle.net/10722/154109
dc.identifier.volume16
dc.languageeng
dc.publisher.placeAustralia
dc.relation.ispartofAustralian orthodontic journal
dc.subject.meshAnimals
dc.subject.meshBone Matrix - Pathology - Transplantation
dc.subject.meshBone Substitutes - Therapeutic Use
dc.subject.meshBone Transplantation - Pathology
dc.subject.meshCollagen - Therapeutic Use
dc.subject.meshConnective Tissue - Ultrastructure
dc.subject.meshDecalcification Technique
dc.subject.meshMacrophages - Ultrastructure
dc.subject.meshMesoderm - Ultrastructure
dc.subject.meshNeutrophils - Ultrastructure
dc.subject.meshOsteoblasts - Ultrastructure
dc.subject.meshOsteocytes - Ultrastructure
dc.subject.meshOsteogenesis - Physiology
dc.subject.meshParietal Bone - Surgery
dc.subject.meshRabbits
dc.subject.meshTransplantation, Autologous
dc.subject.meshTransplantation, Homologous
dc.subject.meshWound Healing
dc.titleUltrastructural identification of cells involved in the healing of intramembranous bone grafts in both the presence and absence of demineralised intramembranous bone matrix.
dc.typeArticle
Author Affiliations
  1. National University of Singapore