File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Demineralized intramembranous bone matrix augments the healing of endochondral bone graft.

TitleDemineralized intramembranous bone matrix augments the healing of endochondral bone graft.
Authors
Issue Date1999
PublisherQuintessence Publishing Co, Inc.
Citation
The International Journal Of Adult Orthodontics And Orthognathic Surgery, 1999, v. 14 n. 3, p. 185-197 How to Cite?
AbstractThe aim of this study was to examine the osteogenic potential of demineralized bone matrix prepared from intramembranous bone (DBMIM) and to examine its effects on the healing of endochondral autogenous bone grafts. Twenty-four defects in 24 New Zealand white rabbits were used as experimental groups. Twelve defects were grafted with endochondral bone, and the other 12 defects were grafted with endochondral bone with DBMIM (EC-DBMIM). One rabbit from each group was sacrificed on days 1, 2, 3, 4, 5, 6, and 7 postgrafting, and the remaining 5 rabbits from each group were sacrificed on day 14 postgrafting. Another 8 defects in 4 rabbits were used as control groups: 4 defects were left empty (passive control), and 4 defects were grafted with rabbit skin collagen (positive control). They were all sacrificed at 14 days after grafting. Serial sections were made across the whole defect. Quantitative analysis was performed on 100 sections of the 14-day experimental groups by image analysis. Four hundred fourteen percent more new bone was formed in defects grafted with composite EC-DBMIM than in those grafted with endochondral bone alone (P < 0.0001). No bone was formed in either passive or positive controls. Histologic examination of the bone grafts revealed intermediate-stage cartilage, and immunohistochemical examination revealed earlier vascularization in the composite EC-DBMIM groups. In conclusion, DBMIM has extremely high osteoinductive properties and greatly enhances the integration of endochondral bone with defects of intramembranous bone in origin.
Persistent Identifierhttp://hdl.handle.net/10722/154074
ISSN
2005 SCImago Journal Rankings: 0.427

 

DC FieldValueLanguage
dc.contributor.authorRabie, ABen_US
dc.contributor.authorChow, KMen_US
dc.contributor.authorWong, RWen_US
dc.date.accessioned2012-08-08T08:23:08Z-
dc.date.available2012-08-08T08:23:08Z-
dc.date.issued1999en_US
dc.identifier.citationThe International Journal Of Adult Orthodontics And Orthognathic Surgery, 1999, v. 14 n. 3, p. 185-197en_US
dc.identifier.issn0742-1931en_US
dc.identifier.urihttp://hdl.handle.net/10722/154074-
dc.description.abstractThe aim of this study was to examine the osteogenic potential of demineralized bone matrix prepared from intramembranous bone (DBMIM) and to examine its effects on the healing of endochondral autogenous bone grafts. Twenty-four defects in 24 New Zealand white rabbits were used as experimental groups. Twelve defects were grafted with endochondral bone, and the other 12 defects were grafted with endochondral bone with DBMIM (EC-DBMIM). One rabbit from each group was sacrificed on days 1, 2, 3, 4, 5, 6, and 7 postgrafting, and the remaining 5 rabbits from each group were sacrificed on day 14 postgrafting. Another 8 defects in 4 rabbits were used as control groups: 4 defects were left empty (passive control), and 4 defects were grafted with rabbit skin collagen (positive control). They were all sacrificed at 14 days after grafting. Serial sections were made across the whole defect. Quantitative analysis was performed on 100 sections of the 14-day experimental groups by image analysis. Four hundred fourteen percent more new bone was formed in defects grafted with composite EC-DBMIM than in those grafted with endochondral bone alone (P < 0.0001). No bone was formed in either passive or positive controls. Histologic examination of the bone grafts revealed intermediate-stage cartilage, and immunohistochemical examination revealed earlier vascularization in the composite EC-DBMIM groups. In conclusion, DBMIM has extremely high osteoinductive properties and greatly enhances the integration of endochondral bone with defects of intramembranous bone in origin.en_US
dc.languageengen_US
dc.publisherQuintessence Publishing Co, Inc.-
dc.relation.ispartofThe International journal of adult orthodontics and orthognathic surgeryen_US
dc.subject.meshAnalysis Of Varianceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBone Matrix - Transplantationen_US
dc.subject.meshBone Transplantation - Methods - Physiologyen_US
dc.subject.meshCollagen - Physiologyen_US
dc.subject.meshColoring Agents - Diagnostic Useen_US
dc.subject.meshImage Processing, Computer-Assisteden_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshOsteogenesis - Physiologyen_US
dc.subject.meshParietal Bone - Blood Supply - Surgeryen_US
dc.subject.meshRabbitsen_US
dc.subject.meshTransplantation, Autologousen_US
dc.subject.meshWound Healing - Physiologyen_US
dc.titleDemineralized intramembranous bone matrix augments the healing of endochondral bone graft.en_US
dc.typeArticleen_US
dc.identifier.emailRabie, AB:rabie@hku.hken_US
dc.identifier.emailWong, RW:fyoung@hkucc.hku.hken_US
dc.identifier.authorityRabie, AB=rp00029en_US
dc.identifier.authorityWong, RW=rp00038en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid10686843-
dc.identifier.scopuseid_2-s2.0-0033255335en_US
dc.identifier.hkuros47524-
dc.identifier.volume14en_US
dc.identifier.issue3en_US
dc.identifier.spage185en_US
dc.identifier.epage197en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridRabie, AB=7007172734en_US
dc.identifier.scopusauthoridChow, KM=7202178189en_US
dc.identifier.scopusauthoridWong, RW=7402127170en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats